DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Art4 and CARM1

DIOPT Version :9

Sequence 1:	NP_001262445.1	Gene:	Art4 / 41219	FlyBaseID:	FBgn0037770	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_954592.1	Gene:	CARM1 / 10498	HGNCID:	23393	Length:	608	Species:	Homo sapiens

Alignment Length:	484	Identity:	275/484 - (56%)
Similarity:	351/484 - (72%)	Gaps:	22/484 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DSQGVVLRVVSDDDRSHVLKEYMIAADTDAAQMGRRSYAVSLDADNLVLRFASEQDQQLFRKVVE 121
            ||.|:.|  .|.:|.. |.| ..::.:|:.:::|::|:.::|..::::::||:..|...|..:::
Human    65 DSAGIAL--YSHEDVC-VFK-CSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILK 125

  Fly   122 NVK-HLRPKSVFSQRTEESSASQYFQFYGYLSQQQNMMQDYVRTSTYQRAILGNAVDFQDKIVLD 185
            ..: |...:||||:|||||||.||||||||||||||||||||||.|||||||.|..||:||||||
Human   126 TCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLD 190

  Fly   186 VGAGSGILSFFAVQAGAAKVYAIEASNMAQYAQQLVESNNVQHKISVIPGKIEEIELPEKVDVII 250
            ||.|||||||||.||||.|:||:|||.|||:|:.||:|||:..:|.|||||:||:.|||:||:||
Human   191 VGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIII 255

  Fly   251 SEPMGYMLYNERMLETYLHARKWLKPQGKMYPTHGDLHIAPFSDESLYSEQYNKANFWYQSAFHG 315
            ||||||||:||||||:||||:|:|||.|.|:||.||:|:|||:||.||.||:.|||||||.:|||
Human   256 SEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHG 320

  Fly   316 VDLTTLHKEGMKEYFRQPIVDTFDIRICMAKSVRHVCDFLNDKEDDLHLISIPLEFHILQTGICH 380
            |||:.|....:.||||||:||||||||.|||||::..:||..||.|||.|.||.:||:|.:|:.|
Human   321 VDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVH 385

  Fly   381 GLAFWFDVEFSGSSQNVWLSTSPTAPLTHWYQVRCLLPMPIFIKQGQTLTGRVLLEANRRQSYDV 445
            ||||||||.|.||...|||||:||.|||||||||||...|:|.|.|.||:|..||.||:|||||:
Human   386 GLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDI 450

  Fly   446 TIDLHIEGTLISSSNTLDLKNPYFRYTGAPVQAPPGTSTQSPSEQYWTQVDTQGSRNSSSMLNGG 510
            :|...::.|...|||.||||||:|||||.....|||:...||||..|       :..|:..|:.|
Human   451 SIVAQVDQTGSKSSNLLDLKNPFFRYTGTTPSPPPGSHYTSPSENMW-------NTGSTYNLSSG 508

  Fly   511 ISVNG----------IGEGMDITHGLMHP 529
            ::|.|          |..|..:.|..:.|
Human   509 MAVAGMPTAYDLSSVIASGSSVGHNNLIP 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art4	NP_001262445.1	PH-like	24..134	CDD:302622	20/77 (26%)
		PRMT5	53..430	CDD:282971	231/373 (62%)
		AdoMet_MTases	183..281	CDD:100107	71/97 (73%)
CARM1	NP_954592.1	CARM1	34..138	CDD:288395	19/76 (25%)
		PRMT5	<172..435	CDD:282971	180/262 (69%)
		Methyltransf_18	184..283	CDD:289607	73/98 (74%)
		Transactivation domain. /evidence=ECO:0000250	499..608		9/39 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142484
Domainoid	1	1.000	336	1.000	Domainoid score	I1119
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10990
Inparanoid	1	1.050	548	1.000	Inparanoid score	I1151
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233082at33208
OrthoFinder	1	1.000	-	-		FOG0004110
OrthoInspector	1	1.000	-	-		oto89707
orthoMCL	1	0.900	-	-		OOG6_104007
Panther	1	1.100	-	-	LDO	PTHR11006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4498
SonicParanoid	1	1.000	-	-		X2851
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790