DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut4EF and ZNF704

DIOPT Version :9

Sequence 1:	NP_001262443.1	Gene:	Glut4EF / 41217	FlyBaseID:	FBgn0267336	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_001354712.1	Gene:	ZNF704 / 619279	HGNCID:	32291	Length:	586	Species:	Homo sapiens

Alignment Length:	808	Identity:	186/808 - (23%)
Similarity:	285/808 - (35%)	Gaps:	296/808 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RRLAKRSIIGTKVCAKGPDGLWYSGTISDVKTPPSYSGPLSPPPPPTFVVPGEAPINADTRYLVR 69
            |||||||.:|::   :|...|..:|.    ...|:....|...|||   |||.||..|...:...
Human     4 RRLAKRSSLGSR---RGGAALQPAGP----APAPAKEAALPGLPPP---VPGPAPAPAPESWRPP 58

  Fly    70 F--DFKTAVESPTATTSSAASTSSTSSTDPSVIV-------------ETRRAANVHISPAQALRR 119
            .  ..::|...|...|.:||:.||     |.:::             ..|....|...|......
Human    59 LPPPPRSAGTGPPRATGAAAAASS-----PVLLLLGEEDEDEEGGSRRRRGLGRVEEKPRGGAEE 118

  Fly   120 SAMIKEFRESDLI--------------------GPGF---RSIMDTELQPG---QRVYFTYNGRE 158
            ....:|..:.:::                    |||.   |......|:.|   :.:.||:
Human   119 EDDDEEEEDEEVVVEVVDGDEDDEDGEERFVPLGPGHAVPRGPARGALKVGSIKREMTFTF---- 179

  Fly   159 QSGDVVKHDATKDEVIVKITTVGNEEPIELKKRLEEVRLLESRRSARLADQDRDTDFARLADMSG 223
            ||.| :|.|..|......:.::..|         |:|:..::::::|:.|.:::.  .|...:..
Human   180 QSED-LKRDCGKKMSHQHVFSLAME---------EDVKTADTKKASRILDHEKEN--TRSICLLE 232

  Fly   224 ERRRTTTHSIEVPSQLTAQHNSRKRPPSDHQDYGNYLETCRAAEILSSMK----LQSP------- 277
            ::|:..:.:|:||.         .|..|:..|    ::...||.:|:|:.    ::||
Human   233 QKRKVVSSNIDVPP---------ARKSSEELD----MDKVTAAMVLTSLSTSPLVRSPPVRPNES 284

  Fly   278 -HGSMADKCSSPGSSSSA---SWSSGS-------PSPPLSDDG-HAHHSPHNIMSPHDA-DNART 329
             .||..:....|.|:||:   |||:.|       ||||||.|. ....||   ..|.|. |.|.
Human   285 LSGSWKEGGCVPSSTSSSGYWSWSAPSDQSNPSTPSPPLSADSFKPFRSP---AQPDDGIDEAE- 345

  Fly   330 RTASVSTSDEGIVIDYKEERKKKSKK--FRCVYRGCVGVVDDLNGVVRHIRKTHLGK--DSHRSA 390
              ||....||.|     ..::|.|.|  |:|:::.|..|:....|:.:|||..|||:  ||..|
Human   346 --ASNLLFDEPI-----PRKRKNSMKVMFKCLWKNCGKVLSTAAGIQKHIRTIHLGRVGDSDYS- 402

  Fly   391 DDDGNEEDFYLEDADDDVEQVKPTLAS-EPTLSHRDMARPPHEDPEYQKQIVGNFKQGRGGSHYN 454
              || |||||..:...:.:.|...|:| .|....:.:|.||            .|.
Human   403 --DG-EEDFYYTEIKLNTDSVADGLSSLAPVSPSQSLASPP------------TFP--------- 443

  Fly   455 HLAQSHGRTISGSNIPSTHQQQLQNNNTSCIPTSHLAHHNYTCPAATATVGSYSSTGTGSVAASS 519
                          ||.:.:.:     |.|..|.                             :.
Human   444 --------------IPDSSRTE-----TPCAKTE-----------------------------TK 460

  Fly   520 SASPIGKHARSSSSRPTHSVAPYPSPTYVQQQQH-HQHTHHHNYAGSSGSSNSSSSSSPVIHSNS 583
            ..:|:.:.|              |:..|:....| :|.|......||:..:.:.||.|
Human   461 LMTPLSRSA--------------PTTLYLVHTDHAYQATPPVTIPGSAKFTPNGSSFS------- 504

  Fly   584 SANNMLQQLSQQNVTVTAHHSQQQQQLQQQQHHQQQQQHSHQQQQQHLLSSVTITPNFHPAQQQH 648
                    :|.|:..||                               .:.:.::|..||..
Human   505 --------ISWQSPPVT-------------------------------FTGIPVSPTHHPVG--- 527

  Fly   649 HHQPMRGHQQQHPQTTAGNMVAQNNSNNHSNGSNPLQQQQHMAQQVAVKHTPHSPGKRTRGENKK 713
                 .|.|:||..|..               |:|.:....:              ::.|||.||
Human   528 -----TGEQRQHAHTVL---------------SSPPRGTVSL--------------RKPRGEGKK 558

  Fly   714 CRKVYGMEKRDQWCTQCRWKKACSRFGD 741
            ||||||||.||.|||.|||||||.||.|
Human   559 CRKVYGMENRDMWCTACRWKKACQRFLD 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut4EF	NP_001262443.1	DUF4772	<123..177	CDD:292616	15/79 (19%)
ZNF704	NP_001354712.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4845
eggNOG	1	0.900	-	-		E1_28PJI
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4471
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D390760at33208
OrthoFinder	1	1.000	-	-		FOG0001758
OrthoInspector	1	1.000	-	-		otm41462
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13006
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6403
SonicParanoid	1	1.000	-	-		X1285
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	10.090