Protein Alignment MAN1A1 and alpha-Man-Ib

DIOPT Version :9

• Sequence 1: XP_005267043.1
• Gene: MAN1A1 / 4121
• HGNCID: 6821
• Length: 736
• Species: Homo sapiens
• Sequence 2: NP_651667.1
• Gene: alpha-Man-Ib / 43436
• FlyBaseID: FBgn0039634
• Length: 685
• Species: Drosophila melanogaster
• Alignment Length: 675
• Identity: 224/675 - (33%)
• Similarity: 342/675 - (50%)
• Gaps: 74/675 - (10%)

Human   110 GRKGSGPA--ALRLTEKFVLLLVFSAF---ITLCFGAIFFLPDSSK---LLSGVLFHSSPALQPA 166
            |||....|  .|...::.:::|..:.|   :.||......|..|.|   ..:.|..:..|.  |.
  Fly    23 GRKSLRRAWNQLPRCQRNLIILGITGFCVTVLLCLSGDQLLAASLKDVDTKAEVAAYQMPL--PN 85

Human   167 ADHKPG-------PGARAEDAAEGRARRREEGAPGDP--------EAALEDNLARIREN-HERAL 215
            ..|.||       ..|.....|:.||.|.|  |..|.        ||...:|:||:.|. ....|
  Fly    86 PHHHPGVDKDVPKDTAAVPVPADKRAPRVE--AVSDKFNELVAYGEANSAENVARLPETVAAEGL 148

Human   216 REAKETLQKLP---EEIQRDI----LLE--KKKVAQD---------QLRD--KAPFRGLPPVDF- 259
            .:|......||   ...::||    :|.  ::.||||         ||..  |.|.. |..|.|
  Fly   149 PQASAMAVALPPPDSNKEQDIGGIDILNNVEEPVAQDPAEPLSEGEQLEQAIKNPLT-LGGVSFK 212

Human   260 -----VPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNI 319
                 :.|| :...:....|..|:::.:....||:|..||.||||.:.|||||:  :|...||
  Fly   213 EHLKKIKPI-LAKGQHFHGATNERQSAVVAAFKHSWAGYKKYAWGHDNLKPISQ--YSHEWFG-- 272

Human   320 KGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEEIF 384
            .|.||||:|||::||.:..||:|.:.|||::|.|:...::::|||.||.:|||||||:|||:.:|
  Fly   273 LGLTIVDSLDTMYIMGLDDEFKEGRDWVEQSLRFDTKRDVNLFEVTIRVLGGLLSAYHLSGDTMF 337

Human   385 RKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGN 449
            ..||.|||.:|||||.:||.||::.:|:......:..|:...|:  :|..|:.|||..||..:..
  Fly   338 LAKAAELGNRLLPAFQSPSNIPYSDVNLGDLSAHSPKWSPDSST--SEVTTIQLEFRDLSRSTNI 400

Human   450 PIFAEKVMNIRTVLNKLEKPQGLYPNYLNPSSGQWGQH-HVSVGGLGDSFYEYLLKAWLMSDKTD 513
            .|:.:....:...::.|||..||.|.::|.::|.:..: .:|:|..|||:||||||.|:.:.:.|
  Fly   401 SIYEQVAHKVNEKVHDLEKNHGLVPIFINANTGTFRNYATISLGARGDSYYEYLLKQWIQTGRKD 465

Human   514 LEAKKM-YFDAVQAIETHLIRKS-SSGLTYIAEWKGGL-LEHKMGHLTCFAGGMFALGADAAPEG 575
            .:...: |..||..:.|.|:|:: .....||.|...|. .:.||.||||:..|...||..   .|
  Fly   466 NDNLILDYMQAVDGVLTQLMRRTPREHWVYIGELINGKDFKPKMDHLTCYLPGTLILGHQ---NG 527

Human   576 MAQHYLELGAEIARTCHESYNRTFMKLGPEAFRF---DGGVEAIATRQNEKYYILRPEVMETYMY 637
            |...:|.|..::..||:::|......|..|...|   :...:.|..:.|:.:.:||||.:|:..|
  Fly   528 MPDSHLILARDLLDTCYQTYMMNPTHLAAEISYFALTEKDDQDIYVKPNDAHNLLRPEFVESLYY 592

Human   638 MWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLHES-YDDVQQSFFLAETLKYLYLIF 701
            .:.:|.:..|:...|:..:|.|.|.:||.||:.:.:|.....: ..|:.:||:::|||||.||:|
  Fly   593 FYSITGNRTYQDMGWKIFQAFETHAKVNAGYTSMGNVKNTQSTRLRDLMESFWMSETLKYFYLLF 657

Human   702 SDD-DLLPLEHWIFNSEAHLLPILP 725
            ||| ..:.||.|:||||.|.||:.|
  Fly   658 SDDRKEIDLEQWVFNSEGHPLPVYP 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAN1A1	XP_005267043.1	Glyco_hydro_47	285..723	CDD:279825	168/446 (38%)
alpha-Man-Ib	NP_651667.1	Glyco_hydro_47	242..680	CDD:279825	168/446 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R728
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.860