DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FBXO11 and UFO1

DIOPT Version :9

Sequence 1:	NP_001262441.1	Gene:	FBXO11 / 41209	FlyBaseID:	FBgn0037760	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_013622.1	Gene:	UFO1 / 854886	SGDID:	S000004553	Length:	668	Species:	Saccharomyces cerevisiae

Alignment Length:	822	Identity:	150/822 - (18%)
Similarity:	256/822 - (31%)	Gaps:	318/822 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 ELPDEVLLAIFSYLMEQDLCRLALVCKRFNTIANDTELWKRLYQS-VFEYDLPLFNPELCKFVFE 433
            :||.|:|:.|||:|.|:||..|..:...|..:.:|.||||.|::| |.....|.|: :..||..|
Yeast    10 DLPPEILINIFSHLDEKDLFTLQELSTHFRNLIHDEELWKNLFKSRVHTTHFPTFS-QSSKFSVE 73

  Fly   434 KPEESEYANPWK--ESFRQLYRGVHVRPGYQERRSSGRSIVFFNTIQAALDYPEERAAAGVFVPA 496
            ..|.:...:.|:  ::.|..|..:..|...|   .|...|||        |||  |.||
Yeast    74 YIERTRGLHHWQHNKAIRTKYTIIPTRNWDQ---PSIERIVF--------DYP--RVAA------ 119

  Fly   497 GAGAGNVVSAGLSN----------------TSASAGVGGASVNALV------NIYEEQVAPTEHP 539
             ...|.:....|.|                |.........::||.|      .::.:.::...:.
Yeast   120 -YNDGTITILQLQNHKRQKKFKKLIYIPCTTPQGCSTMDFNINAAVFGRFDGRVFGKLLSNKSYL 183

  Fly   540 GPLIFLHAGHYKGEYLFIDS--------DVALVGAAPGNV---AESVILER-EAGSTVMFVEGAK 592
            .|::.....|..|.....:|        |.::.|:..|.:   .|:.:::. :..:.|::    |
Yeast   184 TPVMEFTGRHSAGVTAICNSESWDTSREDWSVSGSENGEIIWWCENKLVKMWKVSNRVIW----K 244

  Fly   593 YAYVGYLTLKFSPEVTSTVSHHKH-YCLDIGENCSPTVDNCIIR----------STSVVGAAVCV 646
            .|:....||....|....:...:. :.:||.::    :|...:|          .|.|:.....|
Yeast   245 LAFFKDWTLIMDDEKLYIIHQMQELHSIDIPKD----LDEQPMRVRFFKMDFGSMTLVLADLNNV 305

  Fly   647 GGVNANP-----VIRNCDISDCENVGLYVTDYAQGTYEHNEISRNALAGIWVKNFASPIMRENHI 706
            ..::.||     .:|..::.  |.:.....|......|.|          |  .||.
Yeast   306 YTISVNPNGNFGNLRKLEMP--EQICAVEIDEKTSQREQN----------W--QFAG-------- 348

  Fly   707 HHGRDVGIFTFENGMGYFEKNDIHNNRIAGFEVKAGANPTVVKCEIHHGQTGGIYVHE------- 764
            ..|..:.:.|.:|.:......|:.::.:.            |:|:|...:.  :||.:
Yeast   349 DDGCYISLLTTQNTLYIINIRDLSSSGLK------------VQCKISFDEQ--VYVSQVTNLIVV 399

  Fly   765 ----------NGL-GQFIENRIHSNNFAGVWITSNSNPTIRKNEIYNGHQGGVYIFGEGRGLIEH 818
                      |.: |:.|:..:.:..|.               |.....|..: |.|.
Yeast   400 VALPNVLQILNAMTGELIKTVLKTEKFP---------------EFLKVSQDKI-IMGS------- 441

  Fly   819 NNIYGNALAGIQIRTNSDPIVRHNKIHHGQHGGIYVHEKGQGLIEENEVYSNTLAGVWITTGSTP 883
                ||.|..::. .:||    ..|.||...|                  .||::..|..|.:|.
Yeast   442 ----GNVLNYLKF-VSSD----SKKHHHSTKG------------------KNTVSNKWNETLNTE 479

  Fly   884 V--------LRRNR-IHSGKQVGVYFYDNGHGKL-----EDNDIFNHLYSGVQIRTGSNPVIRGN 934
            :        |||.| ....:.:..|   .|..:|     |:|||        |:|
Yeast   480 LQYYDEDEDLRRKRQSEISRLIDAY---GGDLELSGDTDEENDI--------QLR---------- 523

  Fly   935 KIWGGQNGGVLVYNGGLGLLEQNE--IFDNAMAGVWIKTDSNPTLKRNKIYDGRDGGICIFNGGK 997
                            :.|||..|  ..:.|.||..:..|.:..|:|
Yeast   524 ----------------IALLESQEAQARNQAEAGEPVGDDEDEQLRR------------------ 554

  Fly   998 GILEENDIFRNTQAGVLISTQSH----------------PILRRNRIYD---------------- 1030
             .|||:.:...||..   |:.:|                ..:|::|:.|
Yeast   555 -ALEESQLIYETQTN---SSANHGNNTNDEIDEDDEEFLRAIRQSRVEDERRRHLRNHTTGRRNG 615

  Fly  1031 -------------------------GQAAGVEITNNATATLE 1047
                                     |.:.||:.:||....|:
Yeast   616 PLSDDNFATYGAAESSERTSTENTIGSSVGVDASNNVDEDLQ 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBXO11	NP_001262441.1	F-box-like	370..414	CDD:289689	19/43 (44%)
		Beta_helix	650..796	CDD:289971	23/168 (14%)
		Beta_helix	735..882	CDD:289971	26/164 (16%)
		Beta_helix	919..1077	CDD:289971	28/188 (15%)
		ZnF_UBR1	1093..>1146	CDD:197698
UFO1	NP_013622.1	F-box-like	8..52	CDD:403981	18/41 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I3206
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005000
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000