Protein Alignment FBXO11 and FBXO11

DIOPT Version :10

• Sequence 1: NP_649954.1
• Gene: FBXO11 / 41209
• FlyBaseID: FBgn0037760
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: XP_005264629.1
• Gene: FBXO11 / 80204
• HGNCID: 13590
• Length: 954
• Species: Homo sapiens
• Alignment Length: 949
• Identity: 593/949 - (62%)
• Similarity: 688/949 - (72%)
• Gaps: 112/949 - (11%)

  Fly   292 PPNVHSSVPQQHCGA------LPV-------GAAIEDNNY------MLPARKRSRRLYTQGGEMG 337
            ||.....:||:....      :|.       |...:::.|      :||.|....   |:....|
Human    60 PPPPPPPLPQERNNVGERDDDVPADMVAEESGPGAQNSPYQLRRKTLLPKRTACP---TKNSMEG 121

  Fly   338 PSAGAT---GEAAGAG--TAASGGAGCAPTAAQYLQYELPDEVLLAIFSYLMEQDLCRLALVCKR 397
            .|...|   |..|...  :..|.....|| |.||||.:|||||:|.|||||:||||||.|.||||
Human   122 ASTSTTENFGHRAKRARVSGKSQDLSAAP-AEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKR 185

  Fly   398 FNTIANDTELWKRLYQSVFEYDLPLFNPELCKFVFEKPEESEYANPWKESFRQLYRGVHVRPGYQ 462
            |:.:|||..||||||..||||..|:.:||..||....|||.|:.|||||||:|||:|.||:||:.
Human   186 FSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFA 250

  Fly   463 ER------RSSGR-SIVFFNTIQAALDYPEERAAAGVFVPAGAGAGNVVSAGLSNTSASAGVGGA 520
            |.      |..|| ::::::||:.||                   |.|..|
Human   251 EHFYSNPARYKGRENMLYYDTIEDAL-------------------GGVQEA-------------- 282

  Fly   521 SVNALVNIYEEQVAPTEHPGPLIFLHAGHYKGEYLFIDSDVALVGAAPGNVAESVILEREAGSTV 585
                             |...|||:|:|.|..|:::|:|.:.::|||||.||:.||:|....||.
Human   283 -----------------HFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTF 330

  Fly   586 MFVEGAKYAYVGYLTLKFSPEVTSTVSHHKHYCLDIGENCSPTVDNCIIRSTSVVGAAVCVGGVN 650
            :|:||::.|||||:|::|:|:..|...|:.|:||:|..||||.:|:||||||..||:||||.|..
Human   331 VFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQG 395

  Fly   651 ANPVIRNCDISDCENVGLYVTDYAQGTYEHNEISRNALAGIWVKNFASPIMRENHIHHGRDVGIF 715
            |.|.|::|:||||||||||:||:|||.||.||||.||||||||||..:||:|.||||||||||:|
Human   396 ACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVF 460

  Fly   716 TFENGMGYFEKNDIHNNRIAGFEVKAGANPTVVKCEIHHGQTGGIYVHENGLGQFIENRIHSNNF 780
            ||::||||||..:||.||||||||||.||||||:|||||||||||||||.|.||||||:|::|||
Human   461 TFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNF 525

  Fly   781 AGVWITSNSNPTIRKNEIYNGHQGGVYIFGEGRGLIEHNNIYGNALAGIQIRTNSDPIVRHNKIH 845
            |||||||||:||||.|.|:||:||||||||:||||||.|:|||||||||||||||.|||||||||
Human   526 AGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIH 590

  Fly   846 HGQHGGIYVHEKGQGLIEENEVYSNTLAGVWITTGSTPVLRRNRIHSGKQVGVYFYDNGHGKLED 910
            .||||||||||||||:|||||||||||||||:|||||||||||||||||||||||||||||.|||
Human   591 DGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLED 655

  Fly   911 NDIFNHLYSGVQIRTGSNPVIRGNKIWGGQNGGVLVYNGGLGLLEQNEIFDNAMAGVWIKTDSNP 975
            |||:||:||||||||||||.||.||||||||||:||||.|||.:|.|||||||||||||||||||
Human   656 NDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNP 720

  Fly   976 TLKRNKIYDGRDGGICIFNGGKGILEENDIFRNTQAGVLISTQSHPILRRNRIYDGQAAGVEITN 1040
            ||:||||:|||||||||||||:|:|||||||||.||||||||.||||||:|||:||.|||:||||
Human   721 TLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPILRKNRIFDGFAAGIEITN 785

  Fly  1041 NATATLEHNQIFKNKFGGLCLASGVQPITRGNNIFNNEDEVEKAVSSGQCLYKISSYTSFPMHDF 1105
            :||||||.||||.|:||||.|||||....:.|.|.||:|.:|||||.||||||||||||:|||||
Human   786 HATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDF 850

  Fly  1106 YRCQTCNTTDRNAICVNCIKNCHAGHDVEFIRHD---------------------------RFFC 1143
            |||.||||||||||||||||.||.||||||||||                           ||||
Human   851 YRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRYVAHLLDILPNYFPPHFSNIWVSFCFRFFC 915

  Fly  1144 DCGAGTLSNQCQLQGEPTQDTDTLYDSAAPMESHTLMVN 1182
            |||||||||.|.|.||||.|||||||||.|:||:||..|
Human   916 DCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN 954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FBXO11	NP_649954.1	F-box_FBXO11	368..412	CDD:438863	31/43 (72%)
		Beta_helix	650..798	CDD:463811	115/147 (78%)
		Beta_helix	735..890	CDD:463811	135/154 (88%)
		Beta_helix	919..1075	CDD:463811	126/155 (81%)
		UBR-box_UBR6_FBXO11	1090..1158	CDD:439074	61/94 (65%)
FBXO11	XP_005264629.1	F-box_FBXO11	156..200	CDD:438863	27/43 (63%)
		Beta_helix	331..497	CDD:463811	104/165 (63%)
		Beta_helix	434..589	CDD:463811	123/154 (80%)
		Beta_helix	526..681	CDD:463811	136/154 (88%)
		Beta_helix	664..819	CDD:463811	132/154 (86%)
		UBR-box_UBR6_FBXO11	835..930	CDD:439074	76/121 (63%)