DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FBXO11 and fbxl7

DIOPT Version :9

Sequence 1:	NP_001262441.1	Gene:	FBXO11 / 41209	FlyBaseID:	FBgn0037760	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001073511.1	Gene:	fbxl7 / 569430	ZFINID:	ZDB-GENE-061215-122	Length:	489	Species:	Danio rerio

Alignment Length:	285	Identity:	69/285 - (24%)
Similarity:	93/285 - (32%)	Gaps:	119/285 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 QSTPPALGASSTTASKSTCATVGSSTASTSAAAAAAASASAGSSHQSPYDLRRKISASSHEQWPT 213
            ||.....|:||.::..|      |||..||..|...|:.|..|      ||..:.
Zfish     8 QSGSEGKGSSSISSDLS------SSTDQTSTKAPKNAATSEDS------DLSMRT---------- 50

  Fly   214 SSSSAVAAAAAILVGPSSSSPPLVNPGASPSSSSSSSSSSSSSSSASSSSSSSNVQAPSTSATFP 278
                           .|:.||.|:.|   |.|||:..:.||:|||...:.:.:.|..|.||.|.|
Zfish    51 ---------------VSTPSPALILP---PRSSSAVLNGSSTSSSTFGTETIAMVHMPPTSLTHP 97

  Fly   279 VNNAPTTGATLAQPPNVHSSVPQQHCGALPVGAAIEDNNYMLPARKRSRRLYTQGGEMGPSAGAT 343
            ..       .|.||.:      ||       ||.::
Zfish    98 QR-------CLRQPRD------QQ-------GAPVD----------------------------- 113

  Fly   344 GEAAGAGTAASGGAGCAPTAAQYLQYELPDEVLLAIFSYLMEQDLCRLALVCKRFNTIANDTELW 408
                                      .|||...|.||::|....|||.|.||:|:..:|.|..||
Zfish   114 --------------------------ILPDHAFLQIFTHLPTNQLCRCARVCRRWYNLAWDPRLW 152

  Fly   409 K--RLYQSVFEYD--LPLFNPELCK 429
            :  ||...|...|  |.:....||:
Zfish   153 RTIRLTGDVLHVDRALRVLTRRLCQ 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBXO11	NP_001262441.1	F-box-like	370..414	CDD:289689	20/45 (44%)
		Beta_helix	650..796	CDD:289971
		Beta_helix	735..882	CDD:289971
		Beta_helix	919..1077	CDD:289971
		ZnF_UBR1	1093..>1146	CDD:197698
fbxl7	NP_001073511.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..76		28/107 (26%)
		F-box-like	112..158	CDD:289689	19/100 (19%)
		leucine-rich repeat	127..151	CDD:275381	10/23 (43%)
		leucine-rich repeat	152..185	CDD:275381	8/26 (31%)
		LRR 1	168..193		3/10 (30%)
		AMN1	<183..364	CDD:187754
		leucine-rich repeat	186..211	CDD:275381
		LRR 2	194..219
		leucine-rich repeat	212..233	CDD:275381
		LRR 3	220..245
		leucine-rich repeat	238..271	CDD:275381
		LRR 4	251..279
		leucine-rich repeat	272..297	CDD:275381
		LRR 5	280..305
		AMN1	295..463	CDD:187754
		leucine-rich repeat	298..323	CDD:275381
		LRR 6	306..331
		leucine-rich repeat	324..349	CDD:275381
		LRR 7	332..357
		leucine-rich repeat	350..375	CDD:275381
		LRR 8	358..383
		leucine-rich repeat	376..401	CDD:275381
		LRR 9	384..409
		leucine-rich repeat	402..427	CDD:275381
		LRR 10	410..435
		leucine-rich repeat	428..451	CDD:275381
		LRR 11	436..461
		leucine-rich repeat	454..478	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010