DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FBXO11 and fbxo11b

DIOPT Version :9

Sequence 1:	NP_001262441.1	Gene:	FBXO11 / 41209	FlyBaseID:	FBgn0037760	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_021328223.1	Gene:	fbxo11b / 567742	ZFINID:	ZDB-GENE-110810-2	Length:	879	Species:	Danio rerio

Alignment Length:	889	Identity:	584/889 - (65%)
Similarity:	681/889 - (76%)	Gaps:	68/889 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 GAAIEDNNYMLPARKRS---RRLY--TQGGEMGPSAGATGEAAGAGTAA--SGGAGCAPT--AAQ 365
            |...:::.|.|  |::|   :|..  |:....|.|..||.........|  ||.:...|.  |.|
Zfish    43 GPGAQNSPYQL--RRKSLLPKRTVCPTKNSMEGASTSATENFGHRAKRARVSGKSQDLPAAPAEQ 105

  Fly   366 YLQYELPDEVLLAIFSYLMEQDLCRLALVCKRFNTIANDTELWKRLYQSVFEYDLPLFNPELCKF 430
            |||.:|||||:|.|||||:|||||:.|.|||||:.:|||..||||||..||||..|:.:||..||
Zfish   106 YLQEKLPDEVVLKIFSYLLEQDLCQAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKF 170

  Fly   431 VFEKPEESEYANPWKESFRQLYRGVHVRPGYQER------RSSGR-SIVFFNTIQAALDYPEERA 488
            ....|||.|..|||||||:|||:|.||:||:.|.      |..|| ::::::||:.||
Zfish   171 YQINPEEYEQPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDAL------- 228

  Fly   489 AAGVFVPAGAGAGNVVSAGLSNTSASAGVGGASVNALVNIYEEQVAPTEHPGPLIFLHAGHYKGE 553
                        |.|..|                               |...|||:|:|.|..|
Zfish   229 ------------GGVQEA-------------------------------HFDGLIFVHSGIYTDE 250

  Fly   554 YLFIDSDVALVGAAPGNVAESVILEREAGSTVMFVEGAKYAYVGYLTLKFSPEVTSTVSHHKHYC 618
            :::|:|.:.::|||.|.||:.|::|....||.:|:||::.|||||:|::|:|:..|...|:.|:|
Zfish   251 WIYIESPITMIGAASGKVADKVVIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHC 315

  Fly   619 LDIGENCSPTVDNCIIRSTSVVGAAVCVGGVNANPVIRNCDISDCENVGLYVTDYAQGTYEHNEI 683
            |:|..||||.:|:|:||||..||:||||.|..|.|.|::|:||||||||||:||:|||.||.|||
Zfish   316 LEITVNCSPNIDHCVIRSTCTVGSAVCVSGQGAGPTIKHCNISDCENVGLYITDHAQGIYEDNEI 380

  Fly   684 SRNALAGIWVKNFASPIMRENHIHHGRDVGIFTFENGMGYFEKNDIHNNRIAGFEVKAGANPTVV 748
            |.||||||||||..:||:|.||||||||||:|||::||||||..:||.||||||||||.||||||
Zfish   381 SNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVV 445

  Fly   749 KCEIHHGQTGGIYVHENGLGQFIENRIHSNNFAGVWITSNSNPTIRKNEIYNGHQGGVYIFGEGR 813
            :|||||||||||||||.|.||||||:|::||||||||||||:||||.|.|:||:||||||||:||
Zfish   446 RCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNAIFNGNQGGVYIFGDGR 510

  Fly   814 GLIEHNNIYGNALAGIQIRTNSDPIVRHNKIHHGQHGGIYVHEKGQGLIEENEVYSNTLAGVWIT 878
            ||||.|:|||||||||||||||.|||||||||.||||||||||||||:|||||||||||||||:|
Zfish   511 GLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVT 575

  Fly   879 TGSTPVLRRNRIHSGKQVGVYFYDNGHGKLEDNDIFNHLYSGVQIRTGSNPVIRGNKIWGGQNGG 943
            ||||||||||||||||||||||||||||.||||||:||:||||||||||||.||.||||||||||
Zfish   576 TGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGG 640

  Fly   944 VLVYNGGLGLLEQNEIFDNAMAGVWIKTDSNPTLKRNKIYDGRDGGICIFNGGKGILEENDIFRN 1008
            :||||.|||.:|.|||||||||||||||||||||:||||:|||||||||||||:|:|||||||||
Zfish   641 ILVYNSGLGFIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRN 705

  Fly  1009 TQAGVLISTQSHPILRRNRIYDGQAAGVEITNNATATLEHNQIFKNKFGGLCLASGVQPITRGNN 1073
            .||||||||.|||:||:|||:||.|||:||||:||||||.||||.|:||||.|||||....:.|.
Zfish   706 AQAGVLISTNSHPVLRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNK 770

  Fly  1074 IFNNEDEVEKAVSSGQCLYKISSYTSFPMHDFYRCQTCNTTDRNAICVNCIKNCHAGHDVEFIRH 1138
            |.||:|.:|||||.||||||||||||:||||||||.||||||||||||||||.||.|||||||||
Zfish   771 IMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRH 835

  Fly  1139 DRFFCDCGAGTLSNQCQLQGEPTQDTDTLYDSAAPMESHTLMVN 1182
            ||||||||||||||.|.|.||||.|||||||||.|:||:||..|
Zfish   836 DRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBXO11	NP_001262441.1	F-box-like	370..414	CDD:289689	31/43 (72%)
		Beta_helix	650..796	CDD:289971	114/145 (79%)
		Beta_helix	735..882	CDD:289971	127/146 (87%)
		Beta_helix	919..1077	CDD:289971	126/157 (80%)
		ZnF_UBR1	1093..>1146	CDD:197698	48/52 (92%)
fbxo11b	XP_021328223.1	F-box-like	109..152	CDD:403981	29/42 (69%)
		Beta_helix	283..446	CDD:404168	108/162 (67%)
		Beta_helix	386..532	CDD:404168	118/145 (81%)
		Beta_helix	478..632	CDD:404168	136/153 (89%)
		Beta_helix	616..775	CDD:404168	127/158 (80%)
		zf-UBR	802..>843	CDD:418636	37/40 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581643
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11843
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930