DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FBXO11 and Fbxl21

DIOPT Version :9

Sequence 1:	NP_001262441.1	Gene:	FBXO11 / 41209	FlyBaseID:	FBgn0037760	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_038951543.1	Gene:	Fbxl21 / 306750	RGDID:	1305555	Length:	460	Species:	Rattus norvegicus

Alignment Length:	378	Identity:	80/378 - (21%)
Similarity:	126/378 - (33%)	Gaps:	130/378 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 LPDEVLLAIFSYLMEQDLCRLALVCKRFNTIANDTELWKR----LYQSVFEYDLPLFNPELCKFV 431
            ||..|:|.||.||...|..|.:.||:.:|.:.:..:||::    |.||...| ....:|:|.:.:
  Rat    71 LPHHVILRIFQYLPLVDRARASSVCRSWNEVFHIPDLWRKFEFELNQSATSY-FKSTHPDLIQQI 134

  Fly   432 FEK---------------PEESEYA------------------NPWKESFRQLYRGVHVRPGYQE 463
            .:|               .|.:|.|                  :..|.||..:.:...|
  Rat   135 IKKHAAHLQYVSFKVDSSTESAEAACHILSQLVNCSIQTLGLISTAKPSFMNMPKSHFV------ 193

  Fly   464 RRSSGRSIVFFNTIQAAL----DYPEERAAAGVFVPAGAGAGNVVSAGLSNTSASAGVGGASV-- 522
               |..::||.|:...:.    |.|.:..:..:.|     |.|..:..|...|:...|....:
  Rat   194 ---SALTVVFVNSKSLSSIKIEDTPVDDPSLKILV-----ANNSDTLRLLKMSSCPHVSSDGILC 250

  Fly   523 ---------NALVNIY------------EEQV--------APTEHPGPLIFLHAGHYKGEYLFID 558
                     ...:|.|            |..|        ..:|:||.:.| |:       :...
  Rat   251 VADHCQGLRELALNYYILSDELLLALSSETHVNLEHLRIDVVSENPGQIKF-HS-------IKKP 307

  Fly   559 SDVALVGAAPG-NVAESVILEREAGSTVMFVEGAKYAYVGYLTLKFSPEVTSTVSHHKHYCLDIG 622
            |..|||..:|| ||.....|..|...| .|.|.....:     |.|...|:.|:...      ||
  Rat   308 SWDALVKHSPGVNVVMYFFLYEEEFDT-FFKEETPVTH-----LYFGRSVSRTILGR------IG 360

  Fly   623 ENCSPTVDNCIIRSTSVVGAAVCVGGVNA--NPVIR---NC------DISDCE 664
            .||...::           ..||..|:..  :.:||   :|      .:|:||
  Rat   361 LNCPRLIE-----------LVVCANGLQPLDSELIRIAEHCKNLTALGLSECE 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBXO11	NP_001262441.1	F-box-like	370..414	CDD:289689	16/46 (35%)
		Beta_helix	650..796	CDD:289971	6/26 (23%)
		Beta_helix	735..882	CDD:289971
		Beta_helix	919..1077	CDD:289971
		ZnF_UBR1	1093..>1146	CDD:197698
Fbxl21	XP_038951543.1	F-box-like	68..111	CDD:403981	15/39 (38%)
		leucine-rich repeat	206..231	CDD:275381	5/29 (17%)
		leucine-rich repeat	232..257	CDD:275381	3/24 (13%)
		leucine-rich repeat	258..283	CDD:275381	3/24 (13%)
		leucine-rich repeat	284..318	CDD:275381	9/41 (22%)
		leucine-rich repeat	329..365	CDD:275381	12/47 (26%)
		AMN1	<359..>424	CDD:187754	13/55 (24%)
		leucine-rich repeat	366..392	CDD:275381	6/36 (17%)
		leucine-rich repeat	393..418	CDD:275381	3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010