DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FBXO11 and Fbxo11

DIOPT Version :9

Sequence 1:	NP_001262441.1	Gene:	FBXO11 / 41209	FlyBaseID:	FBgn0037760	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_038968054.1	Gene:	Fbxo11 / 301674	RGDID:	727935	Length:	933	Species:	Rattus norvegicus

Alignment Length:	857	Identity:	578/857 - (67%)
Similarity:	667/857 - (77%)	Gaps:	72/857 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 GAGTAASGGAG---------------CAPTAAQYLQYELPDEVLLAIFSYLMEQDLCRLALVCKR 397
            ||.|:.:...|               .|..|.||||.:|||||:|.|||||:||||||.|.||||
  Rat   127 GASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKR 191

  Fly   398 FNTIANDTELWKRLYQSVFEYDLPLFNPELCKFVFEKPEESEYANPWKESFRQLYRGVHVRPGYQ 462
            |:.:|||..||||||..||||..|:.:||..||....|||.|:.|||||||:|||:|.||:||:.
  Rat   192 FSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFA 256

  Fly   463 ER------RSSGR-SIVFFNTIQAALDYPEERAAAGVFVPAGAGAGNVVSAGLSNTSASAGVGGA 520
            |.      |..|| ::::::||:.||                   |.|..|
  Rat   257 EHFYSNPARYKGRENMLYYDTIEDAL-------------------GGVQEA-------------- 288

  Fly   521 SVNALVNIYEEQVAPTEHPGPLIFLHAGHYKGEYLFIDSDVALVGAAPGNVAESVILEREAGSTV 585
                             |...|||:|:|.|..|:::|:|.:.::|||||.||:.||:|....||.
  Rat   289 -----------------HFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTF 336

  Fly   586 MFVEGAKYAYVGYLTLKFSPEVTSTVSHHKHYCLDIGENCSPTVDNCIIRSTSVVGAAVCVGGVN 650
            :|:||::.|||||:|::|:|:..|...|:.|:||:|..||||.:|:||||||..||:||||.|..
  Rat   337 VFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQG 401

  Fly   651 ANPVIRNCDISDCENVGLYVTDYAQGTYEHNEISRNALAGIWVKNFASPIMRENHIHHGRDVGIF 715
            |.|.|::|:||||||||||:||:|||.||.||||.||||||||||..:||:|.||||||||||:|
  Rat   402 ACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVF 466

  Fly   716 TFENGMGYFEKNDIHNNRIAGFEVKAGANPTVVKCEIHHGQTGGIYVHENGLGQFIENRIHSNNF 780
            ||::||||||..:||.||||||||||.||||||:|||||||||||||||.|.||||||:|::|||
  Rat   467 TFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNF 531

  Fly   781 AGVWITSNSNPTIRKNEIYNGHQGGVYIFGEGRGLIEHNNIYGNALAGIQIRTNSDPIVRHNKIH 845
            |||||||||:||||.|.|:||:||||||||:||||||.|:|||||||||||||||.|||||||||
  Rat   532 AGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIH 596

  Fly   846 HGQHGGIYVHEKGQGLIEENEVYSNTLAGVWITTGSTPVLRRNRIHSGKQVGVYFYDNGHGKLED 910
            .||||||||||||||:|||||||||||||||:|||||||||||||||||||||||||||||.|||
  Rat   597 DGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLED 661

  Fly   911 NDIFNHLYSGVQIRTGSNPVIRGNKIWGGQNGGVLVYNGGLGLLEQNEIFDNAMAGVWIKTDSNP 975
            |||:||:||||||||||||.||.||||||||||:||||.|||.:|.|||||||||||||||||||
  Rat   662 NDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNP 726

  Fly   976 TLKRNKIYDGRDGGICIFNGGKGILEENDIFRNTQAGVLISTQSHPILRRNRIYDGQAAGVEITN 1040
            ||:||||:|||||||||||||:|:|||||||||.||||||||.|||:||:|||:||.|||:||||
  Rat   727 TLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPVLRKNRIFDGFAAGIEITN 791

  Fly  1041 NATATLEHNQIFKNKFGGLCLASGVQPITRGNNIFNNEDEVEKAVSSGQCLYKISSYTSFPMHDF 1105
            :||||||.||||.|:||||.|||||....:.|.|.||:|.:|||||.||||||||||||:|||||
  Rat   792 HATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDF 856

  Fly  1106 YRCQTCNTTDRNAICVNCIKNCHAGHDVEFIRHDRFFCDCGAGTLSNQCQLQGEPTQDTDTLYDS 1170
            |||.||||||||||||||||.||.|||||||||||||||||||||||.|.|.||||.||||||||
  Rat   857 YRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDS 921

  Fly  1171 AAPMESHTLMVN 1182
            |.|:||:||..|
  Rat   922 APPIESNTLQHN 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBXO11	NP_001262441.1	F-box-like	370..414	CDD:289689	32/43 (74%)
		Beta_helix	650..796	CDD:289971	114/145 (79%)
		Beta_helix	735..882	CDD:289971	127/146 (87%)
		Beta_helix	919..1077	CDD:289971	126/157 (80%)
		ZnF_UBR1	1093..>1146	CDD:197698	48/52 (92%)
Fbxo11	XP_038968054.1	F-box-like	163..206	CDD:403981	30/42 (71%)
		Beta_helix	337..500	CDD:404168	109/162 (67%)
		Beta_helix	440..586	CDD:404168	118/145 (81%)
		Beta_helix	532..686	CDD:404168	136/153 (89%)
		Beta_helix	670..829	CDD:404168	127/158 (80%)
		zf-UBR	856..>897	CDD:418636	37/40 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341654
Domainoid	1	1.000	263	1.000	Domainoid score	I1866
eggNOG	1	0.900	-	-		E1_KOG1777
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11843
Inparanoid	1	1.050	1186	1.000	Inparanoid score	I185
OMA	1	1.010	-	-		QHG49227
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005000
OrthoInspector	1	1.000	-	-		oto96134
orthoMCL	1	0.900	-	-		OOG6_104692
Panther	1	1.100	-	-	LDO	PTHR22990
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4648
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760