DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FBXO11 and Fbxo10

DIOPT Version :9

Sequence 1:	NP_001262441.1	Gene:	FBXO11 / 41209	FlyBaseID:	FBgn0037760	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001365748.1	Gene:	Fbxo10 / 269529	MGIID:	2686937	Length:	970	Species:	Mus musculus

Alignment Length:	998	Identity:	219/998 - (21%)
Similarity:	355/998 - (35%)	Gaps:	294/998 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 LPDEVLLAIFSYLMEQDLCRLALVCKRFN--TIANDTELWKRLYQSVFEYDLPLF--NPELCKFV 431
            ||.|:...|.:||...||.|.:|||:.:.  .::.|:..|::|.....|...|.:  .|::
Mouse     6 LPLELWRMILAYLHLPDLGRCSLVCRAWYELILSLDSTRWRQLCLGCTECRHPNWPNQPDV---- 66

  Fly   432 FEKPEESEYANPWKESFRQLY----------------------------RGVHVRPGYQERRSSG 468
              :||.      |:|:|:|.|                            |.:.|.||: |..|.|
Mouse    67 --EPES------WREAFKQHYLASKTWTKNALDLESSICFSLFRRKKERRTLSVGPGH-EFDSLG 122

  Fly   469 RSIVFFNTIQAALDYP---EERAAAGVFVPAGAGAGNVVSAG-LSNTSASAGVGGASVNALVNIY 529
            .::...:.....:.:|   ||:....:.||.     .:|..| |...:..|.:
Mouse   123 SALAMASLYDRIVLFPGVYEEQGEIILKVPV-----EIVGQGKLGEVALLASI------------ 170

  Fly   530 EEQVAPTEHPGPLIFLHA-----------GHYKGEYL-FIDSDVALVGAAPG------------- 569
             :|...|.....|:|:.|           ||.:.:.. |.:..:.:.|  ||
Mouse   171 -DQHCSTTRVCNLVFMPAWFSPIMYKTTSGHIQFDNCNFENGHIQVHG--PGTCQVKFCTFKNTH 232

  Fly   570 ----NVAESVILERE-AGS--TVMFVEG-----AKYAYVGYLTL-KFSPEVTSTVSHHKHYCLDI 621
                ||...::...| .||  ..:.|||     ..:||...|.| |.||.......|.....||:
Mouse   233 VFLHNVPLCMLENCEFVGSENNCVTVEGHPSADKNWAYKYLLGLIKSSPIFLPAEDHDFLMSLDL 297

  Fly   622 ---GENCSPTVDNCIIRSTSVVGAAVC-------------------------------------- 645
               .:..||...:.:|..:....:.||
Mouse   298 ESRDQAWSPRTCDIVIEGSQSPTSPVCSSPKPGSKEAEVGSDGERVAQTPDSSDGGLSPSGEDED 362

  Fly   646 ------------------VGGVNANP--------------------------------------V 654
                              :||....|                                      :
Mouse   363 DEQLTYRLSYQVQGPRPVLGGSFLGPPLPGASIQLPSCLVLNSLHQELQKDKEAMALASSVQGCL 427

  Fly   655 IRNCDISDCENVGLYVTDYAQGTYEHNEISRNALAGIWVKNFASPIMRENHIHHGRDVGIFTFEN 719
            ||.|...|.:. |::|..|.:...|.| :.||....:...:.:..:|..|.|:..|..|||....
Mouse   428 IRKCLFRDGKG-GVFVCSYGRAKMEGN-VFRNLTYAVRCIHNSKIVMLRNDIYRCRASGIFLRLE 490

  Fly   720 GMGYFEKNDIHNNRIAGFEVKAGANPTVVKCEIHHGQTGGIYVHENGLGQFIENRIHSNNFAGVW 784
            |.|....|:|::|..||.:::..:||.::..:||||...||.|..||.|....|:|.||..||::
Mouse   491 GGGLIAGNNIYHNAEAGVDIRKKSNPLILCNQIHHGLRSGIVVLGNGKGVIRNNQIFSNKEAGIY 555

  Fly   785 ITSNSNPTIRKNEIYNGHQGGVYIFGEGRGLIE--------------------HNNIYGNALAGI 829
            |..:.||.:..|.|:.|...|:.:...|:|||.                    .|.|..|...|:
Mouse   556 ILYHGNPIVSGNHIFKGRAAGIAVNENGKGLITVIKACTGRGSWVLTSPHLPIENVIRENQWGGV 620

  Fly   830 QIRTNSDPIVRHNKIHHGQHGGIYVHEKGQGLIEENEVYSNTLAGVWITTGSTPVLRRNRIHSGK 894
            .||....||:|.|.|..|...|:.|.::|:||||.|.:|:|...|||:.:.|.|.:..|.:....
Mouse   621 DIRRGGVPILRSNLICFGYSDGVVVGDEGKGLIEGNTIYANKGCGVWMMSSSLPHVTSNHVSYNG 685

  Fly   895 QVGVYFYD-------NGHGK--------------------------------LEDNDIFNHLYSG 920
            ..||..:.       .|||.                                :|.|.|.::..||
Mouse   686 LYGVAVFSQKDGEFPGGHGAQENFSEDGDAILWEAELEKEDDPLRRPITVALVESNSINHNGASG 750

  Fly   921 VQIRTGSNPVIRGNKIW-GGQNGGVLVYNGGLGLLEQNEIFDNAMAGVWIKTDSNPTLKRNKIYD 984
            :.:::.....:..|.|. .|..|..:|.:..|..:..|.|..|..:||.::......|:.|.|||
Mouse   751 IFVQSSEALQVVANVIHANGDRGITIVQSSQLTRVANNSISCNRQSGVKVEFQCKVELRGNGIYD 815

  Fly   985 GRDGGICIFNGGKGILEENDIFRNTQAGVLISTQSHPILRRNRIYDGQAAGVEITNNATATLEHN 1049
            .|..||.....|..:: ||||..|..:|:.:..:|...:.:|||:..:|.|:.:.....|.::.|
Mouse   816 NRGHGIITKGDGTAVV-ENDIIGNRGSGLQLLPRSDTKVLKNRIHSFRAYGIAVRGRVKALVQEN 879

  Fly  1050 QIFKNKFGGLCLASGVQPITRGNNIFNNEDEVEKAVSSGQCLYKISSYTSF-PMHDFYRCQTCNT 1113
            .||:.|                    .|:...::..::.:|:.:.:.:..| ...|.:|  ..|.
Mouse   880 IIFQGK--------------------TNKTIFQQITNNRECIMQNNKFLVFKKKSDTWR--LVNP 922

  Fly  1114 TDRNAICVNCIKN---CHAGHDV 1133
            ..|..: .|.::.   .|:||.|
Mouse   923 PARPHL-ENSLRGSSAAHSGHKV 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBXO11	NP_001262441.1	F-box-like	370..414	CDD:289689	15/44 (34%)
		Beta_helix	650..796	CDD:289971	47/183 (26%)
		Beta_helix	735..882	CDD:289971	56/166 (34%)
		Beta_helix	919..1077	CDD:289971	39/158 (25%)
		ZnF_UBR1	1093..>1146	CDD:197698	10/45 (22%)
Fbxo10	NP_001365748.1	F-box-like	6..49	CDD:403981	14/42 (33%)
		Beta_helix	460..616	CDD:404168	45/155 (29%)
		Beta_helix	618..811	CDD:404168	47/192 (24%)
		Beta_helix	749..906	CDD:404168	41/177 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837878
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1777
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740