Protein Alignment FBXO11 and FBXO10

DIOPT Version :10

• Sequence 1: NP_649954.1
• Gene: FBXO11 / 41209
• FlyBaseID: FBgn0037760
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: XP_047279175.1
• Gene: FBXO10 / 26267
• HGNCID: 13589
• Length: 1012
• Species: Homo sapiens
• Alignment Length: 967
• Identity: 233/967 - (24%)
• Similarity: 361/967 - (37%)
• Gaps: 279/967 - (28%)

  Fly   321 PARKRS---RRLYTQGGEMG---PSAGATGEAAGAGTAASGGAGCAPTAAQYLQY------ELPD 373
            ||..||   |||....||:.   ||...||.  ||..:|      .|.|.::.:.      .||.
Human     8 PAAPRSPGIRRLRRADGELCLGLPSRKTTGR--GACISA------VPPALRFFECVTMEAGGLPL 64

  Fly   374 EVLLAIFSYLMEQDLCRLALVCKRFN--TIANDTELWKRLYQSVFEYDLPLF--NPELCKFVFEK 434
            |:...|.:||...||.|.:|||:.:.  .::.|:..|::|.....|...|.:  .|::      :
Human    65 ELWRMILAYLHLPDLGRCSLVCRAWYELILSLDSTRWRQLCLGCTECRHPNWPNQPDV------E 123

  Fly   435 PEESEYANPWKESFRQLY----------------------------RGVHVRPGYQERRSSGRSI 471
            ||.      |:|:|:|.|                            |.:.|.|| :|..|.|.::
Human   124 PES------WREAFKQHYLASKTWTKNALDLESSICFSLFRRRRERRTLSVGPG-REFDSLGSAL 181

  Fly   472 VFFNTIQAALDYP---EERAAAGVFVPAGAGAGNVVSAG-LSNTSASAGVG-GASVNALVNI--- 528
            ...:.....:.:|   ||:....:.||.     .:|..| |...:..|.:. ..|...|.|:
Human   182 AMASLYDRIVLFPGVYEEQGEIILKVPV-----EIVGQGKLGEVALLASIDQHCSTTRLCNLVFT 241

  Fly   529 ----------------------YEEQVAPTEHPGPL-----------IFLH-------------- 546
                                  :|........||..           ||||
Human   242 PAWFSPIMYKTTSGHVQFDNCNFENGHIQVHGPGTCQVKFCTFKNTHIFLHNVPLCVLENCEFVG 306

  Fly   547 --------AGH--------YKGEYL-----------------FIDS---------------DVAL 563
                    .||        ||  ||                 |:.|               |:.:
Human   307 SENNSVTVEGHPSADKNWAYK--YLLGLIKSSPTFLPTEDSDFLMSLDLESRDQAWSPKTCDIVI 369

  Fly   564 VGA-----------APGNVAESVILEREAGSTVMFVEGAKYAYV-----GYLTLKFSPEVTSTVS 612
            .|:           .||:.|.|  .|.|.||     :|.:.|..     |.|:.....|....:.
Human   370 EGSQSPTSPASSSPKPGSKAGS--QEAEVGS-----DGERVAQTPDSSDGGLSPSGEDEDEDQLM 427

  Fly   613 HHKHYCLD----------IG---ENCSPTVDNCII---------RSTSVVGAAVCVGGVNANPVI 655
            :...|.:.          :|   ...|..:.:|::         :....:..|..|.|.    :|
Human   428 YRLSYQVQGPRPVLGGSFLGPPLPGASIQLPSCLVLNSLQQELQKDKEAMALANSVQGC----LI 488

  Fly   656 RNCDISDCENVGLYVTDYAQGTYEHNEISRNALAGIWVKNFASPIMRENHIHHGRDVGIFTFENG 720
            |.|...|.:. |::|..:.:...|.| |.||....:...:.:..||..|.|:..|..|||....|
Human   489 RKCLFRDGKG-GVFVCSHGRAKMEGN-IFRNLTYAVRCIHNSKIIMLRNDIYRCRASGIFLRLEG 551

  Fly   721 MGYFEKNDIHNNRIAGFEVKAGANPTVVKCEIHHGQTGGIYVHENGLGQFIENRIHSNNFAGVWI 785
            .|....|:|::|..||.:::..:||.::..:||||...||.|..||.|....|:|.||..||::|
Human   552 GGLIAGNNIYHNAEAGVDIRKKSNPLILCNQIHHGLRSGIVVLGNGKGIIRNNQIFSNKEAGIYI 616

  Fly   786 TSNSNPTIRKNEIYNGHQGGVYIFGEGRGLIEHNNIYGNALAGIQIRTNSDPIVRHNKIHHGQHG 850
            ..:.||.:..|.|:.|...|:.:...|:|||..|.|..|...|:.||....|::|.|.|..|...
Human   617 LYHGNPVVSGNHIFKGRAAGIAVNENGKGLITENVIRENQWGGVDIRRGGIPVLRSNLICFGYSD 681

  Fly   851 GIYVHEKGQGLIEENEVYSNTLAGVWITTGSTPVLRRNRI-HSGKQ-VGVYFYDNGHGKL----- 908
            |:.|.::|:||||.|.:|:|...|||:.:.|.|.:..|.: ::|.. |.|:...:|..:|
Human   682 GVVVGDEGKGLIEGNTIYANKGCGVWMMSSSLPHVTSNHVSYNGLYGVAVFSQKDGSSELPRGHR 746

  Fly   909 ------EDNDIFNHLYSGVQIRTGSNP--------VIRGNKIWGGQNGGVLVY------------ 947
                  ||.|..  |:. .::....:|        ::..|.|  ..||...:|
Human   747 AQENFSEDGDAI--LWE-TELEKEDDPLRRPITIALVESNSI--NHNGASGLYVQSSEALHVITN 806

  Fly   948 ----NGGLGL----------LEQNEIFDNAMAGVWIKTDSNPTLKRNKIYDGRDGGICIFNGGKG 998
                ||..|:          :..|.|..|..:||.::......|:.|.|||.|..|| |..|...
Human   807 VIHANGDRGITVAQSSQPTRVANNSISCNRQSGVKVEAQCKVELRGNGIYDNRGHGI-ITKGDST 870

  Fly   999 ILEENDIFRNTQAGVLISTQSHPILRRNRIYDGQAAGVEITNNATATLEHNQIFKNK 1055
            |:.||||..|..:|:.:..:|...:.:|||:..:|.|:.:...|.|.::.|.||:.|
Human   871 IVIENDIIGNRGSGLQLLPRSDTKVIKNRIHSFRAYGIAVRGRAKALVQENIIFQGK 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FBXO11	NP_649954.1	F-box_FBXO11	368..412	CDD:438863	14/51 (27%)
		Beta_helix	650..798	CDD:463811	48/147 (33%)
		Beta_helix	735..890	CDD:463811	58/154 (38%)
		Beta_helix	919..1075	CDD:463811	43/171 (25%)
		UBR-box_UBR6_FBXO11	1090..1158	CDD:439074
FBXO10	XP_047279175.1	F-box_FBXO10	58..107	CDD:438862	15/48 (31%)
		Beta_helix	520..666	CDD:463811	50/145 (34%)
		Beta_helix	658..853	CDD:463811	48/199 (24%)
		Beta_helix	791..949	CDD:463811	38/138 (28%)