DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FBXO11 and FBXL7

DIOPT Version :9

Sequence 1:NP_001262441.1 Gene:FBXO11 / 41209 FlyBaseID:FBgn0037760 Length:1182 Species:Drosophila melanogaster
Sequence 2:NP_036436.1 Gene:FBXL7 / 23194 HGNCID:13604 Length:491 Species:Homo sapiens


Alignment Length:550 Identity:109/550 - (19%)
Similarity:163/550 - (29%) Gaps:189/550 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   240 GASPSSSSSSSSSSSSSSSASSSSSSSNVQAPSTSATFPVNNAPTTGATLAQPPNVHSSVPQQHC 304
            |:....|||.||..|||:..:.:.:..|| |.|..:...:....|....|..|||          
Human    10 GSEGKGSSSISSDVSSSTDHTPTKAQKNV-ATSEDSDLSMRTLSTPSPALICPPN---------- 63

  Fly   305 GALPVGAAIEDNNYMLPARKRSRRLYTQGGEMGPSAGATGEAAGAGTAASGGA------------ 357
                           ||..:..|      |....|:..|||     |.|...:            
Human    64 ---------------LPGFQNGR------GSSTSSSSITGE-----TVAMVHSPPPTRLTHPLIR 102

  Fly   358 -GCAPTAAQYLQYELPDEVLLAIFSYLMEQDLCRLALVCKRFNTIANDTELWK--RLYQSVFEYD 419
             ...|...|.....|||..::.|||:|....|||.|.||:|:..:|.|..||:  ||.......|
Human   103 LASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVD 167

  Fly   420 --LPLFNPELCKFVFEKP------EESEYANPWKESFRQLYRGVHVRPGYQERRSSGRSIVFFNT 476
              |.:....||:   :.|      |....:...:.:.|.||......|..:....||    .:|.
Human   168 RALKVLTRRLCQ---DTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSG----CYNI 225

  Fly   477 IQAALDYPEERAAAGVFVPAGAGAGNVVSAGLSNTSASAGVGGASVNALVNIYEE---QVAPTEH 538
            ...|           ||        :|||  |........|.|.|....:::..|   :::|   
Human   226 SNEA-----------VF--------DVVS--LCPNLEHLDVSGCSKVTCISLTREASIKLSP--- 266

  Fly   539 PGPLIFLHAGHYKGEYLFIDSDVALVGAAPGNVAESVILEREAGSTV-----------------M 586
                  ||.......||              ::.:..:||.|...|:                 :
Human   267 ------LHGKQISIRYL--------------DMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRL 311

  Fly   587 FVEGAKYAYV-------------------------------GYLTLKFSPEVTST-VSHHKHYCL 619
            ..||.:|..:                               .||::.....||.. :.:...||.
Human   312 TDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCS 376

  Fly   620 DI----GENCSPTVD--------NCIIRSTSVVGAAVCVGGVNANPVIRNC------DISDCENV 666
            .:    ...|....|        ||....:..:|....|.......:..||      .:..||::
Human   377 KLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESI 441

  Fly   667 ---GLYVT-----DYAQGTYEHNEISRNAL 688
               ||.:.     |......:..|:|..||
Human   442 TGQGLQIVAANCFDLQTLNVQDCEVSVEAL 471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FBXO11NP_001262441.1 F-box-like 370..414 CDD:289689 20/45 (44%)
Beta_helix 650..796 CDD:289971 10/52 (19%)
Beta_helix 735..882 CDD:289971
Beta_helix 919..1077 CDD:289971
ZnF_UBR1 1093..>1146 CDD:197698
FBXL7NP_036436.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..79 23/100 (23%)
F-box-like 114..157 CDD:372399 18/42 (43%)
leucine-rich repeat 129..151 CDD:275381 9/21 (43%)
leucine-rich repeat 154..187 CDD:275381 8/35 (23%)
LRR 1 170..195 5/27 (19%)
AMN1 <185..366 CDD:187754 35/228 (15%)
leucine-rich repeat 188..213 CDD:275381 4/24 (17%)
LRR 2 196..221 4/24 (17%)
leucine-rich repeat 214..234 CDD:275381 6/42 (14%)
LRR 3 222..247 9/45 (20%)
leucine-rich repeat 240..273 CDD:275381 7/41 (17%)
LRR 4 253..281 6/50 (12%)
leucine-rich repeat 274..299 CDD:275381 6/38 (16%)
LRR 5 282..307 4/24 (17%)
AMN1 297..464 CDD:187754 22/166 (13%)
leucine-rich repeat 300..325 CDD:275381 3/24 (13%)
LRR 6 308..333 3/24 (13%)
leucine-rich repeat 326..351 CDD:275381 0/24 (0%)
LRR 7 334..359 2/24 (8%)
leucine-rich repeat 352..377 CDD:275381 6/24 (25%)
LRR 8 360..385 4/24 (17%)
leucine-rich repeat 378..403 CDD:275381 4/24 (17%)
LRR 9 386..411 4/24 (17%)
leucine-rich repeat 404..429 CDD:275381 4/24 (17%)
LRR 10 412..437 3/24 (13%)
leucine-rich repeat 430..453 CDD:275381 4/22 (18%)
LRR 11 438..463 5/24 (21%)
leucine-rich repeat 456..480 CDD:275381 3/15 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1027299at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.010

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