DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FBXO11 and Fbxl21

DIOPT Version :9

Sequence 1:	NP_001262441.1	Gene:	FBXO11 / 41209	FlyBaseID:	FBgn0037760	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001333661.1	Gene:	Fbxl21 / 213311	MGIID:	2442921	Length:	460	Species:	Mus musculus

Alignment Length:	376	Identity:	71/376 - (18%)
Similarity:	123/376 - (32%)	Gaps:	126/376 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 LPDEVLLAIFSYLMEQDLCRLALVCKRFNTIANDTELWKR----LYQSVFEYDLPLFNPELCKFV 431
            ||..|:|.||.||...|..|.:.||:|:|.:.:..:||::    |.||...| ....:|:|.:.:
Mouse    71 LPHHVILQIFQYLPLIDRARASSVCRRWNEVFHIPDLWRKFEFELNQSATSY-FKSTHPDLIQQI 134

  Fly   432 FEK---------------PEESEYA------------------NPWKESFRQLYRGVHVRPGYQE 463
            .:|               .|.:|.|                  :..|.||..:.:...|
Mouse   135 IKKHAAHLQYVSFKVDSSTESAEAACDILSQLVNCSIQTLGLISTAKPSFMNVPKSHFV------ 193

  Fly   464 RRSSGRSIVFFNTIQAAL----DYPEERAAAGVFVPAGAGAGNVVSAGLSNTSASAGVGGASVNA 524
               |..::||.|:...:.    |.|.:..:..:.|     |.|..:..|...|:...|....:..
Mouse   194 ---SALTVVFVNSKSLSSIKIEDTPVDDPSLKILV-----ANNSDTLRLLKMSSCPHVSSDGILC 250

  Fly   525 LVN-------------IYEEQVAPTEHPGPLIFLHAGHYKGEYLFIDSDVALVGAAPGNVA---- 572
            :.:             |..:::.       |......|...|:|.||    :|...||.:.
Mouse   251 VADHCQGLRELALNYYILSDEIL-------LALSSETHVNLEHLRID----VVSENPGQIKFHSI 304

  Fly   573 -----ESVILEREAGSTVMFVEGAKYAYVGYLTLKFSPEVTSTVSHHKHYCLD--------IGEN 624
                 :::|......:.||:.    :.|.......|..|...|   |.::...        ||.|
Mouse   305 KKRSWDALIKHSPRVNVVMYF----FLYEEEFEAFFKEETPVT---HLYFGRSVSRAILGRIGLN 362

  Fly   625 CSPTVDNCIIRSTSVVGAAVCVGGV-----NANPVIRNC------DISDCE 664
            |...::           ..||..|:     ....:.::|      .:|:||
Mouse   363 CPRLIE-----------LVVCANGLLPLDSELIRIAKHCKNLTSLGLSECE 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBXO11	NP_001262441.1	F-box-like	370..414	CDD:289689	17/46 (37%)
		Beta_helix	650..796	CDD:289971	4/21 (19%)
		Beta_helix	735..882	CDD:289971
		Beta_helix	919..1077	CDD:289971
		ZnF_UBR1	1093..>1146	CDD:197698
Fbxl21	NP_001333661.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010