DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FBXO11 and BE0003N10.3

DIOPT Version :9

Sequence 1:	NP_001262441.1	Gene:	FBXO11 / 41209	FlyBaseID:	FBgn0037760	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001380182.1	Gene:	BE0003N10.3 / 182047	WormBaseID:	WBGene00015268	Length:	719	Species:	Caenorhabditis elegans

Alignment Length:	815	Identity:	300/815 - (36%)
Similarity:	428/815 - (52%)	Gaps:	163/815 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 DTELWKRLYQSVFEYDLPLFNPELCKFVFEKPEESEYA----NPWKESFRQLYRGVHVRPGYQER 464
            :.|.|:.|||..|.|.||||:||...|.|:...:.::.    |||||::.||.|||||.... |:
Worm     5 EEEEWRVLYQETFGYRLPLFHPEHAVFQFQPAPKQKFTDEEFNPWKEAYEQLSRGVHVMKNL-EQ 68

  Fly   465 RSSGRSIVFFNTIQAALDYPEERAAAGVFVPAGAGAGNVVSAGLSNTSASAGVGGASVNALVNIY 529
            ......|..|:.|:.||.:.:|....|
Worm    69 FVGAADIQCFDHIEEALRFLDENDEGG-------------------------------------- 95

  Fly   530 EEQVAPTEHPGPLIFLHAG-HYKGEYLFIDSDVALVGAAPG-NVAESVILEREAGSTVMFVEGAK 592
                    |...|||||.| |.....:.|.|||.::||:.. ::|.||:|   .|.....:|...
Worm    96 --------HHEKLIFLHEGTHEVTHTIRITSDVQILGASGSEDIATSVVL---TGRHATVLEFQS 149

  Fly   593 YAYVGYLTLKFSPEVTSTVSHHKHYCLD-------------IGE--------------------- 623
            .||:||:|:|:..:    ..|..|...|             :||
Worm   150 SAYMGYVTVKYEVD----TEHEAHVAQDMEVDAPRAGEEVPVGEPGGAPGAPGEPGEPEEALEPE 210

  Fly   624 -----------NCS---------PTVDNCIIRSTSVVGAAVCVGGVNANPVIRNCDISDCENVGL 668
                       ||:         |.:::|..:|.:.....|.|.. :|.|.:|||........|:
Worm   211 KLLEAHTDPTTNCAMIVTGLHVEPIIEHCNFQSGNADSHTVVVKD-HAAPKMRNCTCIGGSGGGI 274

  Fly   669 YVTDYAQGTYEHNEISRNALAGIWVKNFASPIMRENHIHHGRDVGIFTFENGMGYFEKNDIHNNR 733
            .:|.:|.|.|::.|.::|..:||.|:..|:|.....|:||..|||||..::|:|:|:...|:.|:
Worm   275 IITHHAGGYYDNCEFAQNLQSGIRVQFQANPYFYNCHVHHQGDVGIFILDDGLGHFQNCQIYANQ 339

  Fly   734 IAGFEVK-AGANPTVVKCEIHHGQTGGIYVHENGLGQFIENRIHSNNFAGVWITSNSNPTIRKNE 797
            ....|:| |.|||||.:||||||.:|||.:||:..|||::||:|.|.|..:||:..:||.:||||
Worm   340 KFAIELKSAQANPTVTECEIHHGMSGGICIHEDATGQFLKNRLHHNEFLAIWISEGANPIVRKNE 404

  Fly   798 IYNGHQGGVYIFGEGRGLIEHNNIYGNALAGIQIRTNSDPIVRHNKIHHGQHGGIYVHEKGQGLI 862
            |::                                              |:||||:||..|:|||
Worm   405 IFD----------------------------------------------GKHGGIFVHRYGKGLI 423

  Fly   863 EENEVYSNTLAGVWITTGSTPVLRRNRIHSGKQVGVYFYDNGHGKLEDNDIFNHLYSGVQIRTGS 927
            |||:||.|.|||:::.||:.|.:|.|.:|||||.||||||.|.|.||.|:|..:..:|||||||:
Worm   424 EENKVYGNELAGIFVDTGAEPWIRNNHVHSGKQAGVYFYDGGSGVLESNEINGNTLTGVQIRTGA 488

  Fly   928 NPVIRGNKIWGGQNGGVLVYNGGLGLLEQNEIFDNAMAGVWIKTDSNPTLKRNKIYDGRDGGICI 992
            ||.:..|:||...| ||||:..|:|..|:|.||||:|..|:|||.:.|.::||||:..|..||.:
Worm   489 NPRVIKNRIWNNDN-GVLVHEAGMGCFEENTIFDNSMTNVFIKTMATPVIRRNKIFGSRGTGISV 552

  Fly   993 FNGGKGILEENDIFRNTQAGVLISTQSHPILRRNRIYDGQAAGVEITNNATATLEHNQIFKNKFG 1057
            .:||||::|.|:||.|.|||||:.:.|.|.||.|||:..::||:|:::.....|..|::|:|:||
Worm   553 TDGGKGLIEHNEIFDNAQAGVLVLSDSAPSLRGNRIHGNRSAGIEVSSKEELVLAENRVFRNRFG 617

  Fly  1058 GLCLASGVQPITRGNNIFNNEDEVEKAVSSGQCLYKISSYTSFPMHDFYRCQTCNTTDRNAICVN 1122
            |:..||..|.....|.:::|.|.||||:..||||:.:|....:|||:||||.|||::||||||.:
Worm   618 GIMTASCSQASEDQNQVYDNLDHVEKAIKKGQCLFSVSGKDFYPMHNFYRCITCNSSDRNAICQS 682

  Fly  1123 CIKNCHAGHDVEFIRHDRFFCDCGAGTLSNQCQLQ 1157
            ||:.||.||.|.|::.|||:|||||..|...|.|:
Worm   683 CIERCHEGHTVMFLKCDRFYCDCGADHLERSCCLR 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBXO11	NP_001262441.1	F-box-like	370..414	CDD:289689	4/9 (44%)
		Beta_helix	650..796	CDD:289971	62/146 (42%)
		Beta_helix	735..882	CDD:289971	58/147 (39%)
		Beta_helix	919..1077	CDD:289971	73/157 (46%)
		ZnF_UBR1	1093..>1146	CDD:197698	30/52 (58%)
BE0003N10.3	NP_001380182.1	Beta_helix	236..375	CDD:404168	53/139 (38%)
		Beta_helix	349..495	CDD:404168	84/191 (44%)
		Beta_helix	480..619	CDD:404168	68/139 (49%)
		zf-UBR	665..>706	CDD:396677	26/40 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159754
Domainoid	1	1.000	168	1.000	Domainoid score	I2311
eggNOG	1	0.900	-	-		E1_KOG1777
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005000
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104692
Panther	1	1.100	-	-	O	PTHR22990
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.740