Protein Alignment FBXO11 and dre-1

DIOPT Version :9

• Sequence 1: NP_001262441.1
• Gene: FBXO11 / 41209
• FlyBaseID: FBgn0037760
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_001368566.1
• Gene: dre-1 / 179045
• WormBaseID: WBGene00001089
• Length: 1022
• Species: Caenorhabditis elegans
• Alignment Length: 1064
• Identity: 533/1064 - (50%)
• Similarity: 679/1064 - (63%)
• Gaps: 122/1064 - (11%)

  Fly   173 STASTSAAAAAAASASAGSSHQSPYDLR-------RKISASSHEQWPTSSSSAVAA---AAAILV 227
            |..||.||..:......|||....:.:|       |....|:.....|:|:|.|.|   ..:.||
 Worm    19 SLVSTRAAHLSPKLQRRGSSSARKFAIRNLPPSTQRVTRRSTRRGSSTASTSCVPAFEGPTSSLV 83

  Fly   228 GP--SSSSPPLVNP----------GASPSSSSSSSSSSS---SSSSASSSSSSSNVQAPSTSATF 277
            |.  ||||.|..:|          ..|||.|.:|:|.|.   .|...::..|:|...:||.|:
 Worm    84 GQEMSSSSSPFFHPPPQQVMDDTTQQSPSYSQNSNSPSQHTFESMEPAAGGSTSMRYSPSGSS-- 146

  Fly   278 PVNNAPTTGATLAQPPNVHSSVPQQHC------GALPVGAAIEDNNYMLPARKRSRRLYTQGGE- 335
            ..:| ||.|...||....:|...::.|      ...|:.||..|.... |..|:.:......||
 Worm   147 EADN-PTLGLFSAQASYPYSLRKRRPCLTKDEDLCFPITAATADETPQ-PTMKKFKLECLSPGEA 209

  Fly   336 ----MGPSAGATGEAAGAGTAASGGAGCAPTAAQYLQYE--------LPDEVLLAIFSYLMEQDL 388
                :...:|...||....|.      |.|...:.::.|        ||:|:||.:||:|.::.|
 Worm   210 RDFSIEDESGTNLEAKMETTE------CEPEEEEAVEEEDQQDHINRLPEELLLKVFSFLPDKSL 268

  Fly   389 CRLALVCKRFNTIANDTELWKRLYQSVFEYDLPLFNPELCKFVFEKPEESEYANPWKESFRQLYR 453
            ...:.|..|||.|:|..|:||.||.::::|.:|||:|...||.|.:.......||||||.|||:.
 Worm   269 LACSSVSYRFNQISNSHEVWKELYCNLYDYRIPLFHPSHAKFEFREQSRWRDGNPWKESHRQLHH 333

  Fly   454 GVHVRPGYQERRSSGRSIVF--FNTIQAALDYPEERAAAGVFVPAGAGAGNVVSAGLSNTSASAG 516
            ||||   .:|.|.:.||:.:  |:.|:.|..:.||
 Worm   334 GVHV---MKEPRVNLRSVNYRCFDQIEKAQSFLEE------------------------------ 365

  Fly   517 VGGASVNALVNIYEEQVAPTEHPGPLIFLHAG-HYKGEYLFIDSDVALVGAAPG-NVAESVILER 579
                      :.|.|:         |||||.| |...:.:.|::||.::||:.. ::..||:||.
 Worm   366 ----------DEYREK---------LIFLHTGVHEPIDTILINTDVQIIGASDSRDITSSVVLEG 411

  Fly   580 EAGSTVMFVEGAKYAYVGYLTLKF--------SPEVTSTVSHHKHY--CLDIGENCSPTVDNCII 634
            ...:.:.|.:|:..||.|::|::|        .|::........|:  .|...::..|.::.|.|
 Worm   412 SKNTALTFTDGSANAYFGFITVRFRADPVCRQQPQIAQQAQQMNHFYSILVTDKDAMPYIERCDI 476

  Fly   635 RSTSVVGAAVCVGGVNANPVIRNCDISDCENVGLYVTDYAQGTYEHNEISRNALAGIWVKNFASP 699
            .|....|||||| ..:|.|..:.|.:.||||||:|:||.|.|.|||.||:||.|||:||||.|:|
 Worm   477 TSKVGNGAAVCV-KKSAAPKFKYCTVLDCENVGIYITDNATGHYEHCEIARNTLAGVWVKNHANP 540

  Fly   700 IMRENHIHHGRDVGIFTFENGMGYFEKNDIHNNRIAGFEVKAGANPTVVKCEIHHGQTGGIYVHE 764
            ..|:..||.|:|||:||||:|.|||||.:||:|||:|.|||..|||.|::||:|||.||||||||
 Worm   541 YFRKCTIHSGKDVGVFTFEHGQGYFEKCNIHSNRISGIEVKNSANPVVIRCEVHHGYTGGIYVHE 605

  Fly   765 NGLGQFIENRIHSNNFAGVWITSNSNPTIRKNEIYNGHQGGVYIFGEGRGLIEHNNIYGNALAGI 829
            .|.|||:||||::|.:||:||||:|:||||||||:.|.|||||||||||||||.|||||||||||
 Worm   606 RGRGQFMENRIYANAYAGIWITSHSDPTIRKNEIFTGQQGGVYIFGEGRGLIEQNNIYGNALAGI 670

  Fly   830 QIRTNSDPIVRHNKIHHGQHGGIYVHEKGQGLIEENEVYSNTLAGVWITTGSTPVLRRNRIHSGK 894
            |||:.||||||.||||.|.||||||||||:|||||||||.|||||:|:||||:|:||:|||||||
 Worm   671 QIRSQSDPIVRLNKIHDGLHGGIYVHEKGRGLIEENEVYGNTLAGIWVTTGSSPILRKNRIHSGK 735

  Fly   895 QVGVYFYDNGHGKLEDNDIFNHLYSGVQIRTGSNPVIRGNKIWGGQNGGVLVYNGGLGLLEQNEI 959
            ||||||||.|||.||:|||||||||||||||||||.|..|||||||||||||||||.|.||.|||
 Worm   736 QVGVYFYDQGHGLLEENDIFNHLYSGVQIRTGSNPKITRNKIWGGQNGGVLVYNGGKGCLEDNEI 800

  Fly   960 FDNAMAGVWIKTDSNPTLKRNKIYDGRDGGICIFNGGKGILEENDIFRNTQAGVLISTQSHPILR 1024
            ||||||||||||||.|||:|||||||||||:||||.|||:||:|:||||.||||||||:|:|.||
 Worm   801 FDNAMAGVWIKTDSEPTLRRNKIYDGRDGGVCIFNRGKGLLEDNEIFRNAQAGVLISTESNPTLR 865

  Fly  1025 RNRIYDGQAAGVEITNNATATLEHNQIFKNKFGGLCLASGVQPITRGNNIFNNEDEVEKAVSSGQ 1089
            |||::||::||:||||.||||||.||:|:||:||||:|:||.|:.|||.|::|.|.:.:|:.:|.
 Worm   866 RNRVFDGKSAGIEITNGATATLEENQLFRNKYGGLCVATGVTPVQRGNRIYDNHDTISRAIKTGL 930

  Fly  1090 CLYKISSYTSFPMHDFYRCQTCNTTDRNAICVNCIKNCHAGHDVEFIRHDRFFCDCGAGTLSNQC 1154
            ||:|:||..|||||:||||.|||||:|||||.|||:.||.||.||.:|.||||||||||||...|
 Worm   931 CLFKVSSNNSFPMHNFYRCTTCNTTERNAICTNCIRTCHRGHSVELVRFDRFFCDCGAGTLERHC 995

  Fly  1155 QLQGEPTQDTDTLYDSAAPMESHT 1178
            .||..| :|.||:||||.|:.:.|
 Worm   996 HLQNVP-RDNDTVYDSATPISTET 1018

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FBXO11	NP_001262441.1	F-box-like	370..414	CDD:289689	21/51 (41%)
		Beta_helix	650..796	CDD:289971	93/145 (64%)
		Beta_helix	735..882	CDD:289971	114/146 (78%)
		Beta_helix	919..1077	CDD:289971	123/157 (78%)
		ZnF_UBR1	1093..>1146	CDD:197698	38/52 (73%)
dre-1	NP_001368566.1	F-box-like	248..292	CDD:403981	18/43 (42%)
		Beta_helix	484..637	CDD:404168	98/153 (64%)
		Beta_helix	576..723	CDD:404168	114/146 (78%)
		Beta_helix	760..918	CDD:404168	123/157 (78%)
		zf-UBR	946..>987	CDD:418636	30/40 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159753
Domainoid	1	1.000	255	1.000	Domainoid score	I1107
eggNOG	1	0.900	-	-		E1_KOG1777
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11843
Inparanoid	1	1.050	970	1.000	Inparanoid score	I152
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49227
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005000
OrthoInspector	1	1.000	-	-		oto19005
orthoMCL	1	0.900	-	-		OOG6_104692
Panther	1	1.100	-	-	LDO	PTHR22990
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4145
SonicParanoid	1	1.000	-	-		X4648
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.830