DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9467 and shkbp1

DIOPT Version :9

Sequence 1:	NP_001369000.1	Gene:	CG9467 / 41207	FlyBaseID:	FBgn0037758	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_001920935.4	Gene:	shkbp1 / 562395	ZFINID:	ZDB-GENE-130415-1	Length:	841	Species:	Danio rerio

Alignment Length:	723	Identity:	367/723 - (50%)
Similarity:	484/723 - (66%)	Gaps:	84/723 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ASSSDLVNLNVGGQRFSTSRQTLTWIPDTFFTALLSGRISSLRDEHNAIFIDRDPTLFSIILNYL 71
            |...|:::|||||:|||||||||||:||:||::|||||||:|:||..||||||||:||:.|||:|
Zfish     2 ARIGDIIHLNVGGKRFSTSRQTLTWVPDSFFSSLLSGRISTLKDETGAIFIDRDPSLFAPILNFL 66

  Fly    72 RTKDIDIKNCEIRALRHEAEYYGITPLTKRLALCEDLNHSSCGDLLFYGFLAAPPMP----SNEA 132
            |||::..::.::..|.||||:||||||.::|.||::|:.||||::||.|:|..|..|    :..:
Zfish    67 RTKELHPRSIDVHLLIHEAEFYGITPLVRKLQLCDELDRSSCGNVLFNGYLPPPVYPVKRRNRHS 131

  Fly   133 VAATSVDESLPSTSASAIGSRPGSMVRVPEPSRSSHSRNSSWDLRLGRTGSTGNGA---NPPAPM 194
            ||....           :|.|.|.:.|.|.      .|:::....||..|..|..|   ..|.|:
Zfish   132 VAGPQF-----------MGGRSGPVERAPV------RRSNTMPPNLGNAGILGRAAVEERVPGPV 179

  Fly   195 LHSRNPSIDFMRHSRNSSADLNKVFRNEVGLVFSPTQNSNWVDPLRVQIIKAHQNWIAVAYAHFV 259
                                                     .||..|:||..|.||||||||.||
Zfish   180 -----------------------------------------SDPGLVRIICGHHNWIAVAYAQFV 203

  Fly   260 TCYRVKDSNGWQQVFTSPHIDATIERIAINSKVNTSAAEPLPSKMVAISYGSQIRLWSIQEGGQK 324
            .|||||:|.|||||||||.:|..|:|:|:|:||...:... ..||||::.|::|.||:|...|..
Zfish   204 VCYRVKESTGWQQVFTSPRLDWVIDRVALNAKVMGGSLGD-NDKMVAVASGTEIILWAICPDGNG 267

  Fly   325 TDVGTFNLNVRVEYLFFIGSQLVALSSSGKIGVWHAMTQHWQIQDLVPVLSFDSAGSFLLLGCNN 389
            .::|.|:|||.||.|||:|:||:|.|.:||:|||:|:|:|||.||:||:.|:|:|||||:|||||
Zfish   268 NEIGVFSLNVPVEALFFVGNQLIATSHTGKVGVWNAVTKHWQNQDVVPINSYDTAGSFLILGCNN 332

  Fly   390 GSIYYIDMQKFPLRIKDNDLLVTELYKDVTLDPITAISVYLTPKTSSISGNWIEIAYGTKSGAVR 454
            |||||||:||||||:|||||||||||:|.:.|.|||:|||||||||. |||||||||||.||.||
Zfish   333 GSIYYIDVQKFPLRMKDNDLLVTELYRDPSEDAITALSVYLTPKTSD-SGNWIEIAYGTSSGTVR 396

  Fly   455 IIVQHPETAGHGPHLFETFFVHQSPVTKVMLSEKYLVSVCSEYHHVRTWRLTRFRGMLSTQPGST 519
            :|||||||.|.||.||:||.||:|||||:|||||:|:|||::.:|||||.:||||||:|||||||
Zfish   397 VIVQHPETVGSGPQLFQTFSVHRSPVTKIMLSEKHLISVCADNNHVRTWTVTRFRGMISTQPGST 461

  Fly   520 PEASFKIVSLEATDTSYSYAAGNDFGPYGDYDD-MIFVQKVVPETDQLYVRLASNGDRVCVIRSV 583
            |..||||:||:..|.....|||.:.||||:.|: .:|:|:|||:||:|||||:|||.|||.:|||
Zfish   462 PLTSFKILSLDDIDGHAGCAAGTEIGPYGERDEQQVFIQRVVPDTDKLYVRLSSNGKRVCEVRSV 526

  Fly   584 DSSTISAFCVLECEVSS-------RFILTGHCNGAIQMWDLTTALALLSKDEPQQKINGGPDTNE 641
            |.::|:||.|.|||.||       |::.:||.||:|||||||||:.:..|.:  .|..|||...|
Zfish   527 DGTSITAFVVHECEGSSRIGSRPRRYLFSGHSNGSIQMWDLTTAMEIAGKVD--IKALGGPTEEE 589

  Fly   642 LLRLLDQCEISNSSCTTPCMSPCLSAMGNGSGMASSI-ARMKASNIALLNREPAMAMAVQAVQPP 705
            ||.|||||:::.:  .||.|||..|...:......|: ::|..|:.|......|:.::....:.|
Zfish   590 LLELLDQCDLTLT--RTPDMSPAASLTHSSRNSTCSLQSQMSESSRAASGFRSAVPLSGSLPRQP 652

  Fly   706 AQVQPALP 713
                |.:|
Zfish   653 ----PLVP 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9467	NP_001369000.1	BTB_POZ_KCTD3-like	10..95	CDD:349672	54/84 (64%)
shkbp1	XP_001920935.4	BTB	6..96	CDD:197585	59/89 (66%)
		BTB_2	8..100	CDD:280393	59/91 (65%)
		WD40	308..>569	CDD:225201	177/261 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581601
Domainoid	1	1.000	592	1.000	Domainoid score	I197
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	726	1.000	Inparanoid score	I610
OMA	1	1.010	-	-		QHG52417
OrthoDB	1	1.010	-	-		D176271at33208
OrthoFinder	1	1.000	-	-		FOG0003588
OrthoInspector	1	1.000	-	-		otm24776
orthoMCL	1	0.900	-	-		OOG6_105323
Panther	1	1.100	-	-	O	PTHR15859
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2459
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910