DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9467 and KCTD3

DIOPT Version :9

Sequence 1:	NP_001369000.1	Gene:	CG9467 / 41207	FlyBaseID:	FBgn0037758	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_057205.2	Gene:	KCTD3 / 51133	HGNCID:	21305	Length:	815	Species:	Homo sapiens

Alignment Length:	717	Identity:	385/717 - (53%)
Similarity:	488/717 - (68%)	Gaps:	79/717 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ASSSDLVNLNVGGQRFSTSRQTLTWIPDTFFTALLSGRISSLRDEHNAIFIDRDPTLFSIILNYL 71
            |.|.::|.|||||.|||||||||.||||:||::|||||||:||||..||||||||..|:.|||:|
Human    14 AGSGEIVQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPILNFL 78

  Fly    72 RTKDIDIKNCEIRALRHEAEYYGITPLTKRLALCEDLNHSSCGDLLFYGFLAAPPMPSNEAVAAT 136
            |||::|::...|..||||||:||||||.:||.|||:|..||||.:||:|:|..|.:||.
Human    79 RTKELDLRGVSINVLRHEAEFYGITPLVRRLLLCEELERSSCGSVLFHGYLPPPGIPSR------ 137

  Fly   137 SVDESLPSTSASAIGSRPGSMVRVPEPSRSSHSRNSSWDLRLGRTGSTGNGANPPAPMLHSRNPS 201
                                  ::....||:.|||.   |......:.|||..|.
Human   138 ----------------------KINNTVRSADSRNG---LNSTEGEARGNGTQPV---------- 167

  Fly   202 IDFMRHSRNSSADLNKVFRNEVGLVFSPTQNSNWVDPLRVQIIKAHQNWIAVAYAHFVTCYRVKD 266
                         |:......|.|.|.       |||.:|.|:..|.|||..|||||..|||:|:
Human   168 -------------LSGTGEETVRLGFP-------VDPRKVLIVAGHHNWIVAAYAHFAVCYRIKE 212

  Fly   267 SNGWQQVFTSPHIDATIERIAINSKVNTSAAEPLPSKMVAISYGSQIRLWSIQEGGQKTDVGTFN 331
            |:|||||||||::|.||||:|:|:|| .........||||::..|.|.|||:|:||..:::|.|:
Human   213 SSGWQQVFTSPYLDWTIERVALNAKV-VGGPHGDKDKMVAVASESSIILWSVQDGGSGSEIGVFS 276

  Fly   332 LNVRVEYLFFIGSQLVALSSSGKIGVWHAMTQHWQIQDLVPVLSFDSAGSFLLLGCNNGSIYYID 396
            |.|.|:.|||||:||||.|.:||:|||:|:|||||:||:||:.|:|:||||||||||||||||||
Human   277 LGVPVDALFFIGNQLVATSHTGKVGVWNAVTQHWQVQDVVPITSYDTAGSFLLLGCNNGSIYYID 341

  Fly   397 MQKFPLRIKDNDLLVTELYKDVTLDPITAISVYLTPKTSSISGNWIEIAYGTKSGAVRIIVQHPE 461
            |||||||:|||||||||||.|.:.|.|||:|||||||| |:|||||||||||.|||||:||||||
Human   342 MQKFPLRMKDNDLLVTELYHDPSNDAITALSVYLTPKT-SVSGNWIEIAYGTSSGAVRVIVQHPE 405

  Fly   462 TAGHGPHLFETFFVHQSPVTKVMLSEKYLVSVCSEYHHVRTWRLTRFRGMLSTQPGSTPEASFKI 526
            |.|.||.||:||.||:|||||:|||||:|||||::.:|||||.:||||||:||||||||.|||||
Human   406 TVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTVTRFRGMISTQPGSTPLASFKI 470

  Fly   527 VSLEATDTSYSYAAGNDFGPYGDYDD-MIFVQKVVPETDQLYVRLASNGDRVCVIRSVDSSTISA 590
            :|||.|::..||::|||.||:|:.|| .:|:|||||.|::|:|||:|.|.|:|.|::||.:|||:
Human   471 LSLEETESHGSYSSGNDIGPFGERDDQQVFIQKVVPITNKLFVRLSSTGKRICEIQAVDCTTISS 535

  Fly   591 FCVLECEVSS-------RFILTGHCNGAIQMWDLTTALALLSKDEPQQKINGGPDTNELLRLLDQ 648
            |.|.|||.||       |::.|||.||:|||||||||:.:::|.|  .|..|||...|||:||||
Human   536 FTVRECEGSSRMGSRPRRYLFTGHTNGSIQMWDLTTAMDMVNKSE--DKDVGGPTEEELLKLLDQ 598

  Fly   649 CEISNSSCTTPCMSPCLSAMGNGSGMASSIARMKASNIALLNREPAMAMAVQAVQPPAQVQPALP 713
            |::|.|.|.||.:||..|.:.:      |..|...|::.|.:.:.....|......|.:..|.|.
Human   599 CDLSTSRCATPNISPATSVVQH------SHLRESNSSLQLQHHDTTHEAATYGSMRPYRESPLLA 657

  Fly   714 EA 715
            .|
Human   658 RA 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9467	NP_001369000.1	BTB_POZ_KCTD3-like	10..95	CDD:349672	57/84 (68%)
KCTD3	NP_057205.2	BTB_POZ_SHKBP1	17..119	CDD:349701	68/101 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..170		11/56 (20%)
		WD 1	174..218		24/50 (48%)
		WD 2	224..263		17/39 (44%)
		WD 3	270..305		20/34 (59%)
		WD 4	310..342		25/31 (81%)
		WD 5	354..404		40/50 (80%)
		WD 6	412..449		26/36 (72%)
		WD 7	457..504		29/46 (63%)
		WD 8	510..569		31/58 (53%)
		Interaction with HCN3. /evidence=ECO:0000250\|UniProtKB:Q8BFX3	512..815		66/156 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..815
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147766
Domainoid	1	1.000	595	1.000	Domainoid score	I199
eggNOG	1	0.900	-	-		E1_KOG2714
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9395
Inparanoid	1	1.050	728	1.000	Inparanoid score	I618
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52417
OrthoDB	1	1.010	-	-		D176271at33208
OrthoFinder	1	1.000	-	-		FOG0003588
OrthoInspector	1	1.000	-	-		otm41103
orthoMCL	1	0.900	-	-		OOG6_105323
Panther	1	1.100	-	-	LDO	PTHR15859
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3478
SonicParanoid	1	1.000	-	-		X2459
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800