DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9467 and Kctd3

DIOPT Version :9

Sequence 1:	NP_001369000.1	Gene:	CG9467 / 41207	FlyBaseID:	FBgn0037758	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_766238.1	Gene:	Kctd3 / 226823	MGIID:	2444629	Length:	815	Species:	Mus musculus

Alignment Length:	717	Identity:	386/717 - (53%)
Similarity:	497/717 - (69%)	Gaps:	78/717 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ASSSDLVNLNVGGQRFSTSRQTLTWIPDTFFTALLSGRISSLRDEHNAIFIDRDPTLFSIILNYL 71
            |||.::|.|||||.|||||||||.||||:||::|||||||:||||..||||||||..|:.|||:|
Mouse    14 ASSGEIVQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPILNFL 78

  Fly    72 RTKDIDIKNCEIRALRHEAEYYGITPLTKRLALCEDLNHSSCGDLLFYGFLAAPPMPSNEAVAAT 136
            |||::|::...|..||||||:||||||.:||.|||:|..||||.:||:|:|..|.:||.:
Mouse    79 RTKELDLRGVSINVLRHEAEFYGITPLVRRLLLCEELERSSCGSVLFHGYLPPPGIPSRK----- 138

  Fly   137 SVDESLPSTSASAIGSRPGSMVRVPEPSRSSHSRNSSWDLRLGRTGSTGNGANPPAPMLHSRNPS 201
                 :.:|:.|::.:|.|.      .|....:|              |||..   |:|.....
Mouse   139 -----VTNTARSSVDARNGL------NSMEGEAR--------------GNGTQ---PVLAGNGE- 174

  Fly   202 IDFMRHSRNSSADLNKVFRNEVGLVFSPTQNSNWVDPLRVQIIKAHQNWIAVAYAHFVTCYRVKD 266
             |.:|                :|:.         |||.:|.|:..|.|||..|||||..|||:|:
Mouse   175 -DTIR----------------LGVP---------VDPRKVLIVAGHHNWIVAAYAHFAVCYRIKE 213

  Fly   267 SNGWQQVFTSPHIDATIERIAINSKVNTSAAEPLPSKMVAISYGSQIRLWSIQEGGQKTDVGTFN 331
            |:|||||||||::|.||||:|:|:|| .........||||::..|.|.|||:|:||..:::|.|:
Mouse   214 SSGWQQVFTSPYLDWTIERVALNAKV-VGGPHGDKDKMVAVASESSIILWSVQDGGSGSEIGVFS 277

  Fly   332 LNVRVEYLFFIGSQLVALSSSGKIGVWHAMTQHWQIQDLVPVLSFDSAGSFLLLGCNNGSIYYID 396
            |.|.|:.|||||:||||.|.:||:|||:|:|||||:||:||:.|:|:||||||||||||||||||
Mouse   278 LGVPVDALFFIGNQLVATSHTGKVGVWNAVTQHWQVQDVVPITSYDTAGSFLLLGCNNGSIYYID 342

  Fly   397 MQKFPLRIKDNDLLVTELYKDVTLDPITAISVYLTPKTSSISGNWIEIAYGTKSGAVRIIVQHPE 461
            |||||||:|||||||||||.|.:.|.:||:|||||||| |:|||||||||||.|||||:||||||
Mouse   343 MQKFPLRMKDNDLLVTELYHDPSNDAVTALSVYLTPKT-SVSGNWIEIAYGTSSGAVRVIVQHPE 406

  Fly   462 TAGHGPHLFETFFVHQSPVTKVMLSEKYLVSVCSEYHHVRTWRLTRFRGMLSTQPGSTPEASFKI 526
            |.|.||.||:||.||:|||||:|||||:|||||::.:|||||.:||||||:||||||||.|||||
Mouse   407 TVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTVTRFRGMISTQPGSTPLASFKI 471

  Fly   527 VSLEATDTSYSYAAGNDFGPYGDYDD-MIFVQKVVPETDQLYVRLASNGDRVCVIRSVDSSTISA 590
            :|||.|::..||::|||.||:|:.|| .:|:|||||.|::|:|||:|.|.|:|.|::||.:|||:
Mouse   472 LSLEETESHGSYSSGNDIGPFGERDDQQVFIQKVVPITNKLFVRLSSTGKRICEIQAVDCTTISS 536

  Fly   591 FCVLECEVSS-------RFILTGHCNGAIQMWDLTTALALLSKDEPQQKINGGPDTNELLRLLDQ 648
            |.|.|||.||       |::.|||.||:|||||||||:.:::|.|  .|..|||...|||:||||
Mouse   537 FTVRECEGSSRMGSRPRRYLFTGHTNGSIQMWDLTTAMDMVNKTE--DKDAGGPTEEELLKLLDQ 599

  Fly   649 CEISNSSCTTPCMSPCLSAMGNGSGMASSIARMKASNIALLNREPAMAMAVQAVQPPAQVQPALP 713
            |::|.|.|.||.:||..|.:.:      |..|..:|::.|.:.|.....|......|.:..|.|.
Mouse   600 CDLSTSRCATPNISPATSVLQH------SRLRESSSSLQLQHHETIHEAATYGATRPYRESPLLA 658

  Fly   714 EA 715
            .|
Mouse   659 RA 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9467	NP_001369000.1	BTB_POZ_KCTD3-like	10..95	CDD:349672	57/84 (68%)
Kctd3	NP_766238.1	BTB	20..114	CDD:197585	66/93 (71%)
		BTB_2	20..105	CDD:280393	60/84 (71%)
		WD 1	225..272		21/47 (45%)
		WD40	<246..448	CDD:295369	143/202 (71%)
		WD 2	277..314		24/36 (67%)
		WD 3	316..351		29/34 (85%)
		WD 4	420..458		28/37 (76%)
		Interaction with HCN3. /evidence=ECO:0000269\|PubMed:23382386	513..815		67/156 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	707..815
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837848
Domainoid	1	1.000	589	1.000	Domainoid score	I203
eggNOG	1	0.900	-	-		E1_KOG2714
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9395
Inparanoid	1	1.050	723	1.000	Inparanoid score	I625
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52417
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003588
OrthoInspector	1	1.000	-	-		otm43175
orthoMCL	1	0.900	-	-		OOG6_105323
Panther	1	1.100	-	-	LDO	PTHR15859
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3478
SonicParanoid	1	1.000	-	-		X2459
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790