DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9467 and Shkbp1

DIOPT Version :9

Sequence 1:	NP_001369000.1	Gene:	CG9467 / 41207	FlyBaseID:	FBgn0037758	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_619617.2	Gene:	Shkbp1 / 192192	MGIID:	2385803	Length:	704	Species:	Mus musculus

Alignment Length:	741	Identity:	357/741 - (48%)
Similarity:	476/741 - (64%)	Gaps:	98/741 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 THASSSDLVNLNVGGQRFSTSRQTLTWIPDTFFTALLSGRISSLRDEHNAIFIDRDPTLFSIILN 69
            :..:..::::|||||:||||||||||||||:||::|||||||:|:||..|||||||||:|:.|||
Mouse    13 SRGAPGEVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDETGAIFIDRDPTVFAPILN 77

  Fly    70 YLRTKDIDIKNCEIRALRHEAEYYGITPLTKRLALCEDLNHSSCGDLLFYGFLAAPPMPSNEAVA 134
            :||||::|.:.....:|.|||::||:|||.:||.:.|:|:.||||::||.|:|..|..|......
Mouse    78 FLRTKELDPRGVHGSSLLHEAQFYGLTPLVRRLQVREELDRSSCGNVLFNGYLPPPVFPVKRRNR 142

  Fly   135 ATSVDESLPSTSASAIGSRPGSMVRVPEPSRSSHSRNSSWDLRLGRTGSTGNGANPPAPMLHSRN 199
            .:.|       ....||.||.       |.|    |:::....||..|..|.       ||..|.
Mouse   143 HSLV-------GPQQIGGRPA-------PVR----RSNTMPPNLGNAGLLGR-------MLDERA 182

  Fly   200 PSIDFMRHSRNSSADLNKVFRNEVGLVFSPTQNSNWVDPLRVQIIKAHQNWIAVAYAHFVTCYRV 264
            |                            |:.:....:|..|:::..|.|||||||.||:.|||:
Mouse   183 P----------------------------PSPSGQPEEPGMVRLVCGHHNWIAVAYTHFLVCYRL 219

  Fly   265 KDSNGWQQVFTSPHIDATIERIAINSKVNTSAAEPLPSKMVAISYGSQIRLWSIQEGGQKTDVGT 329
            |:::|||..|:||.:|..|||:|:.::| ...|.....||||.:.||:|.||::|..|..:::|.
Mouse   220 KEASGWQLAFSSPRLDWPIERLALAARV-LGGAPGEHDKMVAAATGSEILLWALQAQGGGSEIGV 283

  Fly   330 FNLNVRVEYLFFIGSQLVALSSSGKIGVWHAMTQHWQIQDLVPVLSFDSAGSFLLLGCNNGSIYY 394
            |:|.|.||.|||:|:||:|.|.:|:||||:|:|:|||:|::.|:.|:|:|||||||||:||||||
Mouse   284 FHLGVPVEALFFVGNQLIATSHTGRIGVWNAVTKHWQVQEVQPITSYDAAGSFLLLGCSNGSIYY 348

  Fly   395 IDMQKFPLRIKDNDLLVTELYKDVTLDPITAISVYLTPKTSSISGNWIEIAYGTKSGAVRIIVQH 459
            :|:||||||:|||||||:|||:|...|.:||:|||||||||. |||||||||||.||.||:||||
Mouse   349 VDVQKFPLRMKDNDLLVSELYRDPAEDGVTALSVYLTPKTSD-SGNWIEIAYGTSSGVVRVIVQH 412

  Fly   460 PETAGHGPHLFETFFVHQSPVTKVMLSEKYLVSVCSEYHHVRTWRLTRFRGMLSTQPGSTPEASF 524
            |||.|.||.||:||.||:|||||:|||||:|:|||::.:|||||.:||||||:||||||||.|||
Mouse   413 PETVGSGPQLFQTFSVHRSPVTKIMLSEKHLISVCADNNHVRTWSVTRFRGMISTQPGSTPLASF 477

  Fly   525 KIVSLEATDTSYSYAAGNDFGPYGDYDD-MIFVQKVVPETDQLYVRLASNGDRVCVIRSVDSSTI 588
            ||::||:.|.....:||||.||||:.|| .:|:|||||...||:|||:|.|.|||.:||||.|..
Mouse   478 KILALESVDGLGGCSAGNDIGPYGERDDQQVFIQKVVPNASQLFVRLSSTGQRVCSVRSVDGSPT 542

  Fly   589 SAFCVLECEVS-------SRFILTGHCNGAIQMWDLTTALALLSKDEPQQKINGGPDTNELLRLL 646
            :||.|||||.|       .|::|||..||::.|||||||:     |...|...||....||:..|
Mouse   543 TAFTVLECEGSRRLGSRPRRYLLTGQANGSLAMWDLTTAM-----DGLGQTPAGGLTEEELMDQL 602

  Fly   647 DQCEIS---NSSCTTPCMSP--CLSAMGNGSGMASSIARMKASNIALL----NREPAMAMA---- 698
            :|||:|   :|..:.|..||  .|:::.:.|           ||.:|.    :..|..|.|
Mouse   603 EQCELSPLASSRGSFPSPSPRTSLTSLHSAS-----------SNTSLYGPRGSPSPPQAEARRRG 656

  Fly   699 ----VQAVQPPAQVQPAL--PEAVAP 718
                |...|..|:..|.|  |...||
Mouse   657 AGSFVDRCQELARGAPELRWPPTPAP 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9467	NP_001369000.1	BTB_POZ_KCTD3-like	10..95	CDD:349672	54/84 (64%)
Shkbp1	NP_619617.2	BTB_2	21..106	CDD:280393	56/84 (67%)
		BTB	23..108	CDD:197585	58/84 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..165		8/36 (22%)
		WD 1	233..280		18/47 (38%)
		WD 2	283..322		23/38 (61%)
		WD 3	324..359		25/34 (74%)
		WD 4	428..466		27/37 (73%)
		WD 5	548..586		19/42 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	609..704		20/85 (24%)
		PXXXPR. /evidence=ECO:0000305\|PubMed:21830225	618..623		2/4 (50%)
		PXXXPR. /evidence=ECO:0000305\|PubMed:21830225	678..683		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837847
Domainoid	1	1.000	589	1.000	Domainoid score	I203
eggNOG	1	0.900	-	-		E1_KOG2714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	723	1.000	Inparanoid score	I625
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52417
OrthoDB	1	1.010	-	-		D176271at33208
OrthoFinder	1	1.000	-	-		FOG0003588
OrthoInspector	1	1.000	-	-		otm43175
orthoMCL	1	0.900	-	-		OOG6_105323
Panther	1	1.100	-	-	O	PTHR15859
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2459
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770