DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8507 and AgaP_AGAP003521

DIOPT Version :9

Sequence 1:	NP_649950.1	Gene:	CG8507 / 41205	FlyBaseID:	FBgn0037756	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	XP_313261.4	Gene:	AgaP_AGAP003521 / 1274170	VectorBaseID:	AGAP003521	Length:	383	Species:	Anopheles gambiae

Alignment Length:	392	Identity:	220/392 - (56%)
Similarity:	269/392 - (68%)	Gaps:	35/392 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VAAIALSVLIALQGVDADKKQSKKYSKEANDPHFQQVKQEKYDPDFKSIQRPFRMAKLNLVWAKA 72
            :..|..:||:....|.::|..| ||||.||    .....|.|:|||::||||||||||||||.||
Mosquito     7 LCVIVFTVLVCNHVVQSEKAHS-KYSKHAN----ALPDSEIYEPDFRNIQRPFRMAKLNLVWTKA 66

  Fly    73 QNRLTEPKLKSLYMELKIHDKEEIAWKQLNSQHKDKDGLKADELRRKLIGIMSSYDLLEHFDDTQ 137
            |:|||||||||||.|||:|||||:.:|||  :.|||||||..|||.||:.|||:|.|||||||||
Mosquito    67 QHRLTEPKLKSLYTELKLHDKEELTYKQL--KEKDKDGLKEAELRNKLVSIMSTYGLLEHFDDTQ 129

  Fly   138 DTEKLKPYKKFHDA--EERHRNKSLFKDKKLNRLWEKAEISGFTAEELKSLKQEFDHHQDKVDVY 200
            |.||.|..|....|  ::.::|||||||||||:||:|||.:|||.|||.:|::||||||.|:|||
Mosquito   130 DPEKYKLAKSSDGAPKKDTYKNKSLFKDKKLNKLWDKAESAGFTKEELDALREEFDHHQAKIDVY 194

  Fly   201 YSLLENIG------------TVDTDKHENAINTEDLDTYNLISNDVNEND------IKTHAQNVK 247
            |||||.:|            ..|.|...||:|.|:.|.||.:.. ..|.|      .|.||...|
Mosquito   195 YSLLERLGDDDDGGAAGQGSRRDDDALLNAVNDEEHDRYNEVDR-AEETDRSQPGANKQHAYLHK 258

  Fly   248 SFENDLNTLRGHHTGIKDHYDRLERLVSSGPHSQDFIEPKVQGLWRVAQASNFTVKELESIKTEL 312
            |     |.||..|..|:|::|||:|:.|.||.||||:|||||||||||.||:|:..||.|:|.||
Mosquito   259 S-----NQLREKHREIRDNFDRLDRIASKGPKSQDFVEPKVQGLWRVALASDFSADELASLKVEL 318

  Fly   313 HHFESRLLKLRHLHAEHALQKEKYKGEKVKDKSSRFEEMEDQLKKQTRKVEKLQENIEKTIFKHT 377
            .|:|||||||||:||||||..||:|....|..:.:.  |||.:|||||||||:||.:|:.||||:
Mosquito   319 LHYESRLLKLRHMHAEHALSLEKHKHSDAKADTHKL--MEDNIKKQTRKVEKMQEEVERRIFKHS 381

  Fly   378 EL 379
            ||
Mosquito   382 EL 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8507	NP_649950.1	Alpha-2-MRAP_N	15..140	CDD:399416	81/124 (65%)
CG8507	NP_649950.1	Alpha-2-MRAP_C	161..379	CDD:399417	127/235 (54%)
AgaP_AGAP003521	XP_313261.4	Alpha-2-MRAP_N	15..132	CDD:283943	80/123 (65%)
		3-helical coiled coil	58..67	CDD:269813	7/8 (88%)
		3-helical coiled coil	74..95	CDD:269813	15/20 (75%)
		3-helical coiled coil	104..117	CDD:269813	7/12 (58%)
		Alpha-2-MRAP_C	155..383	CDD:283944	127/235 (54%)
		RAP	155..280	CDD:297195	61/130 (47%)
		3-helical coiled coil	160..167	CDD:269812	4/6 (67%)
		3-helical coiled coil	176..197	CDD:269812	14/20 (70%)
		3-helical coiled coil	264..279	CDD:269812	6/14 (43%)
		RAP_D3	289..383	CDD:269815	60/95 (63%)
		3-helical coiled coil	296..303	CDD:269815	6/6 (100%)
		3-helical coiled coil	310..343	CDD:269815	24/32 (75%)
		3-helical coiled coil	349..378	CDD:269815	15/30 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	241	1.000	Domainoid score	I5109
eggNOG	1	0.900	-	-		E1_KOG3956
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37612
Inparanoid	1	1.050	398	1.000	Inparanoid score	I4001
OMA	1	1.010	-	-		QHG49282
OrthoDB	1	1.010	-	-		D388256at33208
OrthoFinder	1	1.000	-	-		FOG0007150
OrthoInspector	1	1.000	-	-		oto107834
Panther	1	1.100	-	-	LDO	PTHR16560
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6028
TreeFam	1	0.960	-	-
	13	12.940