DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8507 and Lrpap1

DIOPT Version :9

Sequence 1:NP_649950.1 Gene:CG8507 / 41205 FlyBaseID:FBgn0037756 Length:379 Species:Drosophila melanogaster
Sequence 2:NP_001162584.1 Gene:Lrpap1 / 116565 RGDID:620700 Length:360 Species:Rattus norvegicus


Alignment Length:369 Identity:111/369 - (30%)
Similarity:185/369 - (50%) Gaps:65/369 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 KYSKEANDPHFQQVKQEKYDPDFKSIQRPFRMAKLNLVWAKAQN-RLTEPKLKSLYMELKIHDKE 94
            |||:|.|:|. ...|:|..:        .|||.|||.:|.||:. .|:..:|..|:.:|||.:::
  Rat    37 KYSREKNEPE-MAAKRESGE--------EFRMEKLNQLWEKAKRLHLSPVRLAELHSDLKIQERD 92

  Fly    95 EIAWKQLNSQHKDKDGLKADELRRKLIGIMSSYDLLEHFDDTQDTEKLKPYKKFHDAEERHRNKS 159
            |:.||:|..:..|.||.|..:|...|..|::.|.|    |..:||:.:.......|.::.     
  Rat    93 ELNWKKLKVEGLDGDGEKEAKLVHNLNVILARYGL----DGRKDTQTVHSNALNEDTQDE----- 148

  Fly   160 LFKDKKLNRLWEKAEISG-FTAEELKSLKQEFDHHQDKVDVYYSLLENIGTVDTDKHENAINTED 223
             ..|.:|.:||.||:.|| |::|||..|.:||.|:::|:..|..||:.:...: :.:||.::..|
  Rat   149 -LGDPRLEKLWHKAKTSGKFSSEELDKLWREFLHYKEKIHEYNVLLDTLSRAE-EGYENLLSPSD 211

  Fly   224 LDTYNLISNDVNENDIKTHAQNVKSFENDLNTLRGHHTGIKDH-------YDRLERLVSS--GPH 279
            :                ||   :||     :||...|:.:||.       .|||.::...  || 
  Rat   212 M----------------TH---IKS-----DTLASKHSELKDRLRSINQGLDRLRKVSHQGYGP- 251

  Fly   280 SQDFIEPKVQGLWRVAQASNFTVKELESIKTELHHFESRLLKLRHLHAEHALQKEKYK------- 337
            :.:|.||:|..||.:||::|||.|||||.:.||.|||:::.|..|...:..:..:|.|       
  Rat   252 ATEFEEPRVIDLWDLAQSANFTEKELESFREELKHFEAKIEKHNHYQKQLEISHQKLKHVESIGD 316

  Fly   338 GEKVKDKSSRFEEMEDQLKKQTRKVEKLQENIEKTI--FKHTEL 379
            .|.:.....::..:|::.|:...||:|..:::...:  .:|.||
  Rat   317 PEHISRNKEKYVLLEEKTKELGYKVKKHLQDLSSRVSRARHNEL 360

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8507NP_649950.1 Alpha-2-MRAP_N 15..140 CDD:399416 38/109 (35%)
Alpha-2-MRAP_C 161..379 CDD:399417 69/236 (29%)
Lrpap1NP_001162584.1 Alpha-2-MRAP_N 31..134 CDD:283943 38/109 (35%)
3-helical coiled coil 61..70 CDD:269813 5/8 (63%)
3-helical coiled coil 78..99 CDD:269813 8/20 (40%)
3-helical coiled coil 110..123 CDD:269813 4/12 (33%)
Alpha-2-MRAP_C 149..360 CDD:283944 69/236 (29%)
RAP_D2 149..246 CDD:269814 35/121 (29%)
3-helical coiled coil 153..162 CDD:269814 4/8 (50%)
3-helical coiled coil 170..198 CDD:269814 11/27 (41%)
3-helical coiled coil 223..246 CDD:269814 6/22 (27%)
LDL receptor binding. /evidence=ECO:0000255 240..356 35/116 (30%)
RAP_D3 255..360 CDD:269815 32/104 (31%)
3-helical coiled coil 262..269 CDD:269815 3/6 (50%)
3-helical coiled coil 276..309 CDD:269815 12/32 (38%)
3-helical coiled coil 324..353 CDD:269815 5/28 (18%)
Prevents secretion from ER. /evidence=ECO:0000250|UniProtKB:P30533 357..360 1/2 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166353147
Domainoid 1 1.000 96 1.000 Domainoid score I7184
eggNOG 1 0.900 - - E1_KOG3956
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37612
Inparanoid 1 1.050 143 1.000 Inparanoid score I4379
OMA 1 1.010 - - QHG49282
OrthoDB 1 1.010 - - D388256at33208
OrthoFinder 1 1.000 - - FOG0007150
OrthoInspector 1 1.000 - - oto96696
orthoMCL 1 0.900 - - OOG6_107561
Panther 1 1.100 - - LDO PTHR16560
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X6028
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.770

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