DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8500 and DIRAS3

DIOPT Version :9

Sequence 1:	NP_001303452.1	Gene:	CG8500 / 41203	FlyBaseID:	FBgn0037754	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	NP_004666.1	Gene:	DIRAS3 / 9077	HGNCID:	687	Length:	229	Species:	Homo sapiens

Alignment Length:	190	Identity:	88/190 - (46%)
Similarity:	123/190 - (64%)	Gaps:	2/190 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DYRVVVFGAGGVGKSSLVLRFIKGTFRESYIPTIEDTYRQVISCNKNICTLQITDTTGSHQFPAM 82
            ||||||.|..|||||:|:.::..|.||..|:||||:||.|::.|:..:.:|.|||:.......|:
Human    37 DYRVVVVGTAGVGKSTLLHKWASGNFRHEYLPTIENTYCQLLGCSHGVLSLHITDSKSGDGNRAL 101

  Fly    83 QRLSISKGHAFILVYSVCSKQSLEELRPIWALIKELKGADIPNIPVMLVGNKCDETAELREVSQA 147
            ||..|::||||:|||||..|::||||:..:.||.::||.::...|::|||||.|:|.  |||:..
Human   102 QRHVIARGHAFVLVYSVTKKETLEELKAFYELICKIKGNNLHKFPIVLVGNKSDDTH--REVALN 164

  Fly   148 EGQAQATTWSISFMETSAKTNHNVTELFQELLNMEKTRTVSLQLDTKKQKKQKKEKKSKD 207
            :|...|..|:.:|||.||||:.||.|||..|||.:|..|..||...||.:.....:|..|
Human   165 DGATCAMEWNCAFMEISAKTDVNVQELFHMLLNYKKKPTTGLQEPEKKSQMPNTTEKLLD 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8500	NP_001303452.1	ARHI_like	18..183	CDD:206711	80/164 (49%)
DIRAS3	NP_004666.1	P-loop_NTPase	37..200	CDD:328724	80/164 (49%)
DIRAS3	NP_004666.1	Effector region. /evidence=ECO:0000255	66..74		5/7 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S634
OMA	1	1.010	-	-		QHG48239
OrthoDB	1	1.010	-	-		D1218505at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24070
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.980