Protein Alignment CG8500 and RASD2

DIOPT Version :10

• Sequence 1: NP_649948.1
• Gene: CG8500 / 41203
• FlyBaseID: FBgn0037754
• Length: 233
• Species: Drosophila melanogaster
• Sequence 2: NP_055125.2
• Gene: RASD2 / 23551
• HGNCID: 18229
• Length: 266
• Species: Homo sapiens
• Alignment Length: 263
• Identity: 87/263 - (33%)
• Similarity: 131/263 - (49%)
• Gaps: 33/263 - (12%)

  Fly     2 TEQKNQVTRAAPEQSNDYRVVVFGAGGVGKSSLVLRFIKGTFRESYIPTIEDTYRQVISCNKNIC 66
            |......|.:.|.: |.||:||.||..|||||:|.||:.|.|.:.|.|||||.:|:|.:...::.
Human     4 TLSSGNCTLSVPAK-NSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVYNIRGDMY 67

  Fly    67 TLQITDTTGSHQFPAMQRLSISKGHAFILVYSVCSKQSLEELRPIWALIKELKGA------DIPN 125
            .|.|.||:|:|.||||:||||..|..||||:|:.:::|.:|::.:...|.|:|..      :...
Human    68 QLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKSCLKNKTKEAAE 132

  Fly   126 IPVMLVGNKCDETAELREVSQAEGQAQAT-TWSISFMETSAKTNHNVTELFQELLNMEKT----- 184
            :|:::.|||.|.....|:|...|.:...: ..:.::.|.|||.|.||.|:|..|.:|.|.
Human   133 LPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVDEMFYVLFSMAKLPHEMS 197

  Fly   185 ----RTVSLQLDTKKQKKQ--KKEKKSKDTNGSIPE-------NGD-----AGASASGGAKE--K 229
                |.:|:|.......:.  .:..|..|..|.:..       |.|     |.....|.|:|  |
Human   198 PALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSVNSDLKYIKAKVLREGQARERDK 262

  Fly   230 CRV 232
            |.:
Human   263 CTI 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8500	NP_649948.1	ARHI_like	18..183	CDD:206711	68/171 (40%)
RASD2	NP_055125.2	Rhes_like	20..266	CDD:133343	83/246 (34%)
		Effector region	48..56		6/7 (86%)
		Interaction with GNB1, GNB2 and GNB3. /evidence=ECO:0000269|PubMed:19255495	189..235		8/45 (18%)