DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and ZNF623

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_055604.3	Gene:	ZNF623 / 9831	HGNCID:	29084	Length:	536	Species:	Homo sapiens

Alignment Length:	556	Identity:	140/556 - (25%)
Similarity:	198/556 - (35%)	Gaps:	170/556 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 TSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQE---KPH 172
            |..|..||..:  ....||..:|.:|:..                     :|:..|:.|   :|.
Human    14 TGEKKVTEAWI--SEDENSHRTTSDRLTV---------------------MELPSPESEEVHEPR 55

  Fly   173 LVPTVSAPPAPL--SKPASERVIRENQVRLRRY-----------IKDEMKYDLATGIESSRKNAA 224
            |...:..|....  |.|:.:|..:  ||.:..:           .|....:.|.:.:...::...
Human    56 LGELLGNPEGQSLGSSPSQDRGCK--QVTVTHWKIQTGETAQVCTKSGRNHILNSDLLLLQRELI 118

  Fly   225 KG-PNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQ 288
            :| .|.|.:|.:.|...|.||||...||        .|:|:|           |:.||:.|....
Human   119 EGEANPCDICGKTFTFNSDLVRHRISHA--------GEKPYT-----------CDQCGKGFGQSS 164

  Fly   289 VAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSS 353
            ....|..||..|.
Human   165 HLMEHQRIHTGER---------------------------------------------------- 177

  Fly   354 LILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAI 418
                 :..|..|...|...:.|:.|...|..|:.|:|..|.       :|..|       ..:.|
Human   178 -----LYVCNVCGKDFIHYSGLIEHQRVHSGEKPFKCAQCG-------KAFCH-------SSDLI 223

  Fly   419 RSLNV-TLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNF----EF 478
            |...| |..|.|.|..|...|:.:.||..|:  ..|...|..|        |:.|..:|    ..
Human   224 RHQRVHTRERPFECKECGKGFSQSSLLIRHQ--RIHTGERPYE--------CNECGKSFIRSSSL 278

  Fly   479 AHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQE 543
            ...:..|:|                    ::||.|..|||::...|.|.:|.|.|.|.:||.|.|
Human   279 IRHYQIHTE--------------------VKQYECKECGKAFRHRSDLIEHQRIHTGERPFECNE 323

  Fly   544 ENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFY 608
              |.:.|.....|..| ::.|||||||:|..|||||...|.|.||:.||.||:.|||.||||.|:
Human   324 --CGKAFIRSSKLIQH-QRIHTGERPYVCNECGKRFSQTSNFTQHQRIHTGEKLYECNECGKAFF 385

  Fly   609 RADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKH 644
            .:..|..||:|||||:.|.|..|.|.|.|:....:|
Human   386 LSSYLIRHQKIHTGERVYECKECGKAFLQKAHLTEH 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..453	CDD:275368	6/21 (29%)
		COG5048	<450..647	CDD:227381	72/199 (36%)
		C2H2 Zn finger	469..490	CDD:275368	5/24 (21%)
		zf-C2H2	511..533	CDD:278523	9/21 (43%)
		C2H2 Zn finger	513..564	CDD:275368	18/50 (36%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	15/25 (60%)
		C2H2 Zn finger	572..592	CDD:275368	10/19 (53%)
		zf-H2C2_2	585..609	CDD:290200	15/23 (65%)
		zf-C2H2	598..620	CDD:278523	11/21 (52%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	13/24 (54%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
ZNF623	NP_055604.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..77		3/19 (16%)
		COG5048	123..494	CDD:227381	118/422 (28%)
		C2H2 Zn finger	125..145	CDD:275368	8/19 (42%)
		C2H2 Zn finger	153..173	CDD:275368	5/19 (26%)
		C2H2 Zn finger	181..201	CDD:275368	5/19 (26%)
		C2H2 Zn finger	209..229	CDD:275368	6/33 (18%)
		C2H2 Zn finger	237..257	CDD:275368	6/21 (29%)
		C2H2 Zn finger	265..285	CDD:275368	3/19 (16%)
		C2H2 Zn finger	293..313	CDD:275368	8/19 (42%)
		C2H2 Zn finger	321..341	CDD:275368	6/22 (27%)
		C2H2 Zn finger	349..369	CDD:275368	10/19 (53%)
		C2H2 Zn finger	377..397	CDD:275368	9/19 (47%)
		C2H2 Zn finger	405..425	CDD:275368	6/17 (35%)
		C2H2 Zn finger	433..453	CDD:275368
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	489..509	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910