DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and AZF1

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_014756.3	Gene:	AZF1 / 854280	SGDID:	S000005639	Length:	914	Species:	Saccharomyces cerevisiae

Alignment Length:	639	Identity:	120/639 - (18%)
Similarity:	200/639 - (31%)	Gaps:	238/639 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 VPQQEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNE 229
            :|.||...|..|.:.       ..|.:.::|.:.|||:::.||..|..|......:.:..:|
Yeast   396 IPNQEDHSLASTDTT-------SNSRKDLKEIEQRLRKHLNDEDNYSSAISRPLDKNDVIEG--- 450

  Fly   230 CTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHG 294
                      :.||.:|:::..:         ||:.|
Yeast   451 ----------SEGLNKHIDESGM---------QPNII---------------------------- 468

  Fly   295 LIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSV 359
                              ...:.|.:.:.:..||            ..|:||..:..|:...|:.
Yeast   469 ------------------KKRKKDDSTVYVKNEM------------PRTDPPMSKDNSTSAEGAA 503

  Fly   360 LQCEFC--EYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLN 422
            : ..|.  |....||:     |.|..|......|..|..|
Yeast   504 M-ANFSGKEPPIPDIS-----SVSDDATNLIGATKVDQLM------------------------- 537

  Fly   423 VTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSE 487
                                |:.:.|...|.......::|          |:.|....|.|....
Yeast   538 --------------------LIIQARKKGFTEKVNTTQDG----------DLLFNQTMDILPPKS 572

  Fly   488 EKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTI 552
            |. :...::.|.|:||.|  ::::.|..|.:.::|::||..|:|.|.|.|||||.
Yeast   573 EL-VGGVEKPKGTQNTRA--VKKHECPYCHRLFSQATHLEVHVRSHIGYKPFVCD---------- 624

  Fly   553 RPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQ 617
                                 .|||||..|.....|..:|.||:.|.|:.|.|:|.|...|..|.
Yeast   625 ---------------------YCGKRFTQGGNLRTHERLHTGEKPYSCDICDKKFSRKGNLAAHL 668

  Fly   618 RIHTGEKPYSCLF--CTKTFRQRGDRDKHIRARHSH-LDANSRLMMQM---QKFQLET------- 669
            ..|...||:.|..  |.|||.|.|:...|....|.. |:|.:..:.:|   :...||.
Yeast   669 VTHQKLKPFVCKLENCNKTFTQLGNMKAHQNRFHKETLNALTAKLAEMNPSENIPLEERQLLEYF 733

  Fly   670 -----------------AAAQKAQSHNPEQQ------------DNDVAGGASTSDVPSGS--GFM 703
                             ...:|:...:||..            :|.:|..:..:..|.|:  ...
Yeast   734 ASIYKNSNRGIKGRGKGVGTKKSTISSPENHPASTILNPNTNANNAIANDSENNGNPEGNIDSSS 798

  Fly   704 STEPSVAEMQYSITPEQQEEMVCVPIDEVNNSFFMSHYMQAVPMEEDGSGQHII 757
            ::.|....|   |:|.|::      :..:.:.|..:::..:| ...:.|.|.||
Yeast   799 NSNPGSHSM---ISPTQKD------MGTLQSQFIQNNFNNSV-NSSNPSNQPII 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	3/19 (16%)
		C2H2 Zn finger	277..297	CDD:275368	0/19 (0%)
		C2H2 Zn finger	431..453	CDD:275368	2/21 (10%)
		COG5048	<450..647	CDD:227381	55/198 (28%)
		C2H2 Zn finger	469..490	CDD:275368	5/20 (25%)
		zf-C2H2	511..533	CDD:278523	7/21 (33%)
		C2H2 Zn finger	513..564	CDD:275368	14/50 (28%)
		C2H2 Zn finger	541..561	CDD:275368	1/19 (5%)
		zf-H2C2_2	555..581	CDD:290200	5/25 (20%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	585..609	CDD:290200	9/23 (39%)
		zf-C2H2	598..620	CDD:278523	8/21 (38%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:290200	10/26 (38%)
		C2H2 Zn finger	628..646	CDD:275368	8/19 (42%)
AZF1	NP_014756.3	COG5048	342..768	CDD:227381	105/553 (19%)
		C2H2 Zn finger	595..615	CDD:275368	7/19 (37%)
		C2H2 Zn finger	623..643	CDD:275368	8/50 (16%)
		C2H2 Zn finger	651..671	CDD:275368	7/19 (37%)
		C2H2 Zn finger	679..702	CDD:275368	8/22 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100