DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and ZNF430

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_079465.3	Gene:	ZNF430 / 80264	HGNCID:	20808	Length:	570	Species:	Homo sapiens

Alignment Length:	719	Identity:	164/719 - (22%)
Similarity:	235/719 - (32%)	Gaps:	236/719 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DDLQPGATVLATNESTGGLERIVSHEELSRFFAVGPAGALPMPTDVVVERTLADPAFKQILQEAD 89
            ::|:.|...|.......|.:|.:.   :..|:..||...    .||.:|.:|.:   .|.|..|.
Human     2 ENLKSGVYPLKEASGCPGADRNLL---VYSFYEKGPLTF----RDVAIEFSLEE---WQCLDTAQ 56

  Fly    90 GKKGFDPQAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCP---TCLVQFDAVAF 151
            .........|..:...||||:..||                         |   |||.|...
Human    57 QDLYRKVMLENYRNLVFLAGIAVSK-------------------------PDLITCLEQGKE--- 93

  Fly   152 QNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPAS----ERVIREN--QVRLRRYIK----- 205
                          |...|.|.:  |..||...|..|.    |:.|:::  :|.||||.|
Human    94 --------------PWNMKRHAM--VDQPPVTYSHFAQDLWPEQGIKDSFQEVILRRYGKCGHED 142

  Fly   206 --------------------DEMKYDLAT---------------------GIESSRKNAAKGPNE 229
                                ||:...|.|                     .|:..| :..|.|.:
Human   143 LQLRTGCKSVDECNLHKECYDELNQCLTTTQSEIFQYDKYVNVFYKFSNPNIQKIR-HTGKKPFK 206

  Fly   230 CTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHG 294
            |..||:.|.....|.:|...|.     .:.|.|              |..||::|.......||.
Human   207 CKKCDKSFCMLLHLTQHKRIHI-----RENSYQ--------------CEECGKVFNWFSTLTRHR 252

  Fly   295 LIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSV 359
            .||..|                                            .|.|
Human   253 RIHTGE--------------------------------------------KPYK----------- 262

  Fly   360 LQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVT 424
              ||.|...|...:.|..|...|..|:.:.|..|....|.:...:.|.:..             |
Human   263 --CEQCGKAFKQSSTLTTHKIIHTGEKPYRCEECGKTFNRSSHLTTHKRIH-------------T 312

  Fly   425 LSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLP--CDFCDVNFEFAHDFLAHSE 487
            ..:.:.|..|...|..:..|..|         ::...|:|   |  |:.|...|..:.....|
Human   313 GEKPYRCEECGRAFNRSSHLTTH---------KIIHTGEK---PYKCEECGKAFNQSSTLTTH-- 363

  Fly   488 EKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTI 552
                         :...||. :.|.|:.|||::.:.|:|.:|...|.|.|.:.|:|  |.:.|..
Human   364 -------------KIIHAGE-KPYKCEECGKAFYRFSYLTKHKIIHTGEKFYKCEE--CGKGFNW 412

  Fly   553 RPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQ 617
            ...|..| ::.||||:||.|..|||.|...|....|::||.||:.|:||||||.|.|:..|..|:
Human   413 SSTLTKH-KRIHTGEKPYKCEQCGKAFNESSNLTAHKIIHTGEKPYKCEECGKAFNRSPKLTAHK 476

  Fly   618 RIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQK-FQLETAAAQKAQSHNPE 681
            .||:|||||.|..|.|.|.|..:..||   :.:|:...|...::..| |...:...:....|..|
Human   477 VIHSGEKPYKCEECGKAFNQFSNLTKH---KITHIGDTSYKYLECDKAFSQSSTLTKHKVIHTGE 538

  Fly   682 QQDN 685
            :..|
Human   539 KPYN 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	431..453	CDD:275368	5/21 (24%)
		COG5048	<450..647	CDD:227381	68/198 (34%)
		C2H2 Zn finger	469..490	CDD:275368	4/20 (20%)
		zf-C2H2	511..533	CDD:278523	8/21 (38%)
		C2H2 Zn finger	513..564	CDD:275368	16/50 (32%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	13/25 (52%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	585..609	CDD:290200	13/23 (57%)
		zf-C2H2	598..620	CDD:278523	11/21 (52%)
		C2H2 Zn finger	600..620	CDD:275368	10/19 (53%)
		zf-H2C2_2	612..637	CDD:290200	13/24 (54%)
		C2H2 Zn finger	628..646	CDD:275368	7/17 (41%)
ZNF430	NP_079465.3	KRAB	35..96	CDD:214630	20/109 (18%)
		KRAB	35..74	CDD:279668	8/45 (18%)
		COG5048	202..562	CDD:227381	115/464 (25%)
		C2H2 Zn finger	207..227	CDD:275368	6/19 (32%)
		C2H2 Zn finger	235..255	CDD:275368	6/19 (32%)
		zf-H2C2_2	248..272	CDD:290200	11/80 (14%)
		C2H2 Zn finger	263..283	CDD:275368	6/19 (32%)
		zf-H2C2_2	276..300	CDD:290200	6/23 (26%)
		C2H2 Zn finger	291..311	CDD:275368	4/19 (21%)
		zf-H2C2_2	303..328	CDD:290200	5/37 (14%)
		C2H2 Zn finger	319..339	CDD:275368	5/28 (18%)
		zf-H2C2_2	331..356	CDD:290200	8/36 (22%)
		C2H2 Zn finger	347..367	CDD:275368	4/34 (12%)
		C2H2 Zn finger	375..395	CDD:275368	7/19 (37%)
		C2H2 Zn finger	403..423	CDD:275368	6/22 (27%)
		zf-H2C2_2	416..439	CDD:290200	12/23 (52%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		zf-H2C2_2	443..468	CDD:290200	13/24 (54%)
		C2H2 Zn finger	459..479	CDD:275368	10/19 (53%)
		zf-H2C2_2	472..496	CDD:290200	13/23 (57%)
		C2H2 Zn finger	487..507	CDD:275368	7/22 (32%)
		C2H2 Zn finger	515..535	CDD:275368	2/19 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910