DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and ZNF671

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_079109.2	Gene:	ZNF671 / 79891	HGNCID:	26279	Length:	534	Species:	Homo sapiens

Alignment Length:	625	Identity:	138/625 - (22%)
Similarity:	230/625 - (36%)	Gaps:	170/625 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ERIVSHEELSRFFAVGPAGALPMPTDVVV---ERTLADPAFKQI----LQEADGKKGFDPQAEQM 101
            :|::.|:.:...||:..:..:.......|   ||......:.|:    ..|.:.::|..|....
Human    70 QRLLYHDVMLENFALLASLGIAFSRSRAVMKLERGEEPWVYDQVDMTSATEREAQRGLRPGCWH- 133

  Fly   102 KIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVP 166
                   ||...::::|||:|        .:.|:.::  |.:.:     .::|.|:
Human   134 -------GVEDEEVSSEQSIF--------VAGVSEVR--TLMAE-----LESHPCD--------- 167

  Fly   167 QQEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNECT 231
                      :..|            |.::.:.|.:|          .|.::.:|     |..|.
Human   168 ----------ICGP------------ILKDTLHLAKY----------HGGKARQK-----PYLCG 195

  Fly   232 MCDRKFVHASGLVRHM-EKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGL 295
            .|.::|..::...:|. :.:...|.|.:  |...::.:..:||..|..:||:...|  .:...||
Human   196 ACGKQFWFSTDFDQHQNQPNGGKLFPRK--EGRDSVKSCRVHVPEKTLTCGKGRRD--FSATSGL 256

  Fly   296 I-HDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGS- 358
            : |.:..|:|:....|                                      ::.|..::|.
Human   257 LQHQASLSSMKPHKST--------------------------------------KLVSGFLMGQR 283

  Fly   359 VLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNV 423
            ..:|..|...|.....|..|...|..||.:||..|         .....|:..:|..:.:.
Human   284 YHRCGECGKAFTRKDTLARHQRIHTGERPYECNEC---------GKFFSQSYDLFKHQTVH---- 335

  Fly   424 TLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEE 488
            |..|.:.|:.|...|.....|.|||  ..|...||.:.||        |...|....:.:.|.|.
Human   336 TGERPYECSECGKFFRQISGLIEHR--RVHTGERLYQCGK--------CGKFFSSKSNLIRHQEV 390

  Fly   489 KHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIR 553
                         :|||   |.|:|..|||.:::...|..|.|.|.|.:|:.|.|  |.:.|:..
Human   391 -------------HTGA---RPYVCSECGKEFSRKHTLVLHQRTHTGERPYECSE--CGKAFSQS 437

  Fly   554 PDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQR 618
            ..||.|.| .|:.:  |.|..|||.|...|...||:.:|.||:.|||.:|||.|.:...|..|.:
Human   438 SHLNVHWR-IHSSD--YECSRCGKAFSCISKLIQHQKVHSGEKPYECSKCGKAFTQRPNLIRHWK 499

  Fly   619 IHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRL 658
            :||||:||.|..|.:.|.:     |.....|..:.|..:|
Human   500 VHTGERPYVCSECGREFIR-----KQTLVLHQRVHAGEKL 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	4/20 (20%)
		C2H2 Zn finger	277..297	CDD:275368	5/20 (25%)
		C2H2 Zn finger	431..453	CDD:275368	7/21 (33%)
		COG5048	<450..647	CDD:227381	64/196 (33%)
		C2H2 Zn finger	469..490	CDD:275368	4/20 (20%)
		zf-C2H2	511..533	CDD:278523	8/21 (38%)
		C2H2 Zn finger	513..564	CDD:275368	18/50 (36%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	555..581	CDD:290200	11/25 (44%)
		C2H2 Zn finger	572..592	CDD:275368	8/19 (42%)
		zf-H2C2_2	585..609	CDD:290200	12/23 (52%)
		zf-C2H2	598..620	CDD:278523	9/21 (43%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:290200	11/24 (46%)
		C2H2 Zn finger	628..646	CDD:275368	4/17 (24%)
ZNF671	NP_079109.2	KRAB	49..109	CDD:214630	7/38 (18%)
		KRAB	49..88	CDD:279668	4/17 (24%)
		C2H2 Zn finger	243..269	CDD:275368	8/27 (30%)
		COG5048	<285..443	CDD:227381	52/198 (26%)
		zf-C2H2	285..307	CDD:278523	5/21 (24%)
		C2H2 Zn finger	287..307	CDD:275368	5/19 (26%)
		zf-H2C2_2	300..324	CDD:290200	8/32 (25%)
		C2H2 Zn finger	315..335	CDD:275368	4/28 (14%)
		zf-H2C2_2	327..352	CDD:290200	6/28 (21%)
		C2H2 Zn finger	343..363	CDD:275368	7/21 (33%)
		zf-C2H2	369..391	CDD:278523	6/42 (14%)
		C2H2 Zn finger	371..391	CDD:275368	6/40 (15%)
		zf-C2H2	397..419	CDD:278523	8/21 (38%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		zf-H2C2_2	412..436	CDD:290200	10/25 (40%)
		C2H2 Zn finger	427..447	CDD:275368	8/22 (36%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	466..490	CDD:290200	12/23 (52%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
		C2H2 Zn finger	509..529	CDD:275368	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100