DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and ZNF212

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_036388.2	Gene:	ZNF212 / 7988	HGNCID:	13004	Length:	495	Species:	Homo sapiens

Alignment Length:	173	Identity:	50/173 - (28%)
Similarity:	73/173 - (42%)	Gaps:	26/173 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 CDFCDVNFEFAHDFLAH-----------SEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQ 522
            |..|::.|.:......|           .||...:.:.|.:....|...::.|  ||:|.:|::.
Human   318 CSECEITFRYKQQLATHLRSHSGWGSCTPEEPEESLRPRPRLKPQTKKAKLHQ--CDVCLRSFSC 380

  Fly   523 SSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPD----LNDHI--RKCHTGERPYLCLVCGKRFLT 581
            ...|..|.|.|....|...|  :...:|:  |:    |..||  ||..:.   .:|..|||.|..
Human   381 KVSLVTHQRCHLQEGPSAGQ--HVQERFS--PNSLVALPGHIPWRKSRSS---LICGYCGKSFSH 438

  Fly   582 GSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEK 624
            .|...:|:.||.|||.|.|.||.|.|.:...|..||:||..|:
Human   439 PSDLVRHQRIHTGERPYSCTECEKSFVQKQHLLQHQKIHQRER 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368
		COG5048	<450..647	CDD:227381	50/173 (29%)
		C2H2 Zn finger	469..490	CDD:275368	6/31 (19%)
		zf-C2H2	511..533	CDD:278523	7/21 (33%)
		C2H2 Zn finger	513..564	CDD:275368	17/56 (30%)
		C2H2 Zn finger	541..561	CDD:275368	6/25 (24%)
		zf-H2C2_2	555..581	CDD:290200	10/31 (32%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	585..609	CDD:290200	12/23 (52%)
		zf-C2H2	598..620	CDD:278523	9/21 (43%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:290200	6/13 (46%)
		C2H2 Zn finger	628..646	CDD:275368
ZNF212	NP_036388.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		KRAB_A-box	142..180	CDD:143639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..290
		C2H2 Zn finger	318..338	CDD:275370	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..361		3/23 (13%)
		COG5048	<367..479	CDD:227381	41/120 (34%)
		C2H2 Zn finger	371..391	CDD:275368	7/19 (37%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		zf-C2H2	429..449	CDD:306579	7/19 (37%)
		zf-H2C2_2	441..466	CDD:316026	12/24 (50%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..495		3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100