DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment topi and znf438

DIOPT Version :9

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:NP_001070629.1 Gene:znf438 / 798757 ZFINID:ZDB-GENE-060929-868 Length:746 Species:Danio rerio


Alignment Length:775 Identity:142/775 - (18%)
Similarity:258/775 - (33%) Gaps:253/775 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 PAGALPMPTDVVVERTLADPAFKQILQEADGKKG-FD----PQAEQM------------------ 101
            |..|||..:..|..:::..||....|.:..|::| |.    ||.:|.                  
Zfish    51 PPSALPEASTAVSPKSILVPAQNYALMQVAGQEGTFSLVALPQTQQQQPIQKNLKLPIPRYQPVR 115

  Fly   102 ----------KIR-------------DFLAGVTSSKMTTEQSVFHGSRSNSSASTV--------- 134
                      ||:             ..|....||:..:||.|...:.::|..|..         
Zfish   116 SKSAPEKGGNKIQSPTKVSATTHAQSSILKTEQSSEPLSEQLVLPDTPASSDISIAPLLPASHVD 180

  Fly   135 ----------------------------------NRIKCPTCLVQFDAVAFQNHSCEAKPIE-VA 164
                                              .:|:||..  ...|:...:.:..:|.:: :.
Zfish   181 QKVEQKSDVGPLRNQPYPSGTSLVASIKKISPVKTQIECPAS--AGSAITVLSPTIFSKAVQIIP 243

  Fly   165 VPQQEKPHLVP------TVSAPPAPLSKPASERVI-----------RENQVRLRRYIKDEMKYD- 211
            .|.:.|..::|      ::.||.:..|.|.|::..           .||:|   ::|.:::|.: 
Zfish   244 SPPKGKLPILPYAKVKNSLLAPTSLASTPFSDKQTVSWAKSSPKNPTENKV---KFINNKVKTES 305

  Fly   212 LATGIESS--RKNAAKGP--NECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLH 272
            |:..:.::  :|.:.|.|  ...||.|.....|      .:|.:|.....:..|:|   |..   
Zfish   306 LSQDLNNTQFKKPSGKKPGRKRKTMGDILAFEA------RKKRSLSFFRRRVPEKP---PPG--- 358

  Fly   273 VVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSP----------MTQVPSNRADFN--ELLLD 325
              |:.::..:.|.|....:|          ::|..|          :..:||..|..|  :.||.
Zfish   359 --VQNSASQQKFLDISKKYR----------SIRPKPVLVMEATIPQLVPLPSMSASDNPDQDLLA 411

  Fly   326 GEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFEC 390
            |:.:.....:...|:|.|:..           .||.|:        :...:::::|.:..|   |
Zfish   412 GQQISGKTLSAPQSSQATDRQ-----------PVLNCK--------VNSGVIYTSSRLLHR---C 454

  Fly   391 TACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLS-RYFVCNVCELKFANTDLLQEHRCTSFHY 454
            ..|    |...:...|.|:          .:|...: |.:||.||...:|::..|..|  ...|:
Zfish   455 PTC----NRCFQFKHHLQS----------HMNSHSNLRPYVCPVCRKAYAHSGSLSTH--MKLHH 503

  Fly   455 FPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKS 519
                .|:..:..|.|:||:.:|.:...:.:|..|.|        ....|....|.|:...|   |
Zfish   504 ----AESKPRKSLCCEFCEKSFGYVGVYFSHLREVH--------RVILTVEPSISQHEESI---S 553

  Fly   520 YTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRP---DLNDHIRKCHTGERPYLCLVCGKRF-- 579
            ..:||.:.:... .|.|.|...|.: |.|...|.|   |:..|:...| ||...:.|..|...  
Zfish   554 VEESSEIDEQAS-EQRVDPVELQIK-CGRCQAITPTFADMKLHLLYVH-GEEVQVRLRDGAMHGG 615

  Fly   580 ------LTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKP------------- 625
                  |.....:..|.::.......|..|.:.|:.....|:|...:..|.|             
Zfish   616 REAEDELVKHAAHYWRQLNEKRNLVHCGTCNEEFFSFSKFKHHLHSNHQESPEEEEEEEEKEEKM 680

  Fly   626 -----------------YSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLE 668
                             ::|:.|:|.|.::.:..:|..|:|:  ..|..|:..:..|:.|
Zfish   681 VIGKGLSKDISLRVGSHFNCILCSKVFNKKQEVIEHWSAQHN--CENPTLLWDVLDFKGE 738

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275368 4/19 (21%)
C2H2 Zn finger 277..297 CDD:275368 3/19 (16%)
C2H2 Zn finger 431..453 CDD:275368 6/21 (29%)
COG5048 <450..647 CDD:227381 46/237 (19%)
C2H2 Zn finger 469..490 CDD:275368 6/20 (30%)
zf-C2H2 511..533 CDD:278523 4/21 (19%)
C2H2 Zn finger 513..564 CDD:275368 14/53 (26%)
C2H2 Zn finger 541..561 CDD:275368 7/22 (32%)
zf-H2C2_2 555..581 CDD:290200 7/33 (21%)
C2H2 Zn finger 572..592 CDD:275368 4/27 (15%)
zf-H2C2_2 585..609 CDD:290200 4/23 (17%)
zf-C2H2 598..620 CDD:278523 5/21 (24%)
C2H2 Zn finger 600..620 CDD:275368 5/19 (26%)
zf-H2C2_2 612..637 CDD:290200 8/54 (15%)
C2H2 Zn finger 628..646 CDD:275368 5/17 (29%)
znf438NP_001070629.1 zf-C2H2 452..474 CDD:278523 7/38 (18%)
C2H2 Zn finger 454..474 CDD:275368 6/33 (18%)
zf-H2C2_2 466..491 CDD:290200 8/34 (24%)
C2H2 Zn finger 482..502 CDD:275368 6/21 (29%)
C2H2 Zn finger 514..532 CDD:275368 5/17 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24390
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.100

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