Protein Alignment topi and zmp:0000001228

DIOPT Version :10

• Sequence 1: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: XP_073800154.1
• Gene: zmp:0000001228 / 797319
• ZFINID: ZDB-GENE-140106-188
• Length: 388
• Species: Danio rerio
• Alignment Length: 500
• Identity: 127/500 - (25%)
• Similarity: 172/500 - (34%)
• Gaps: 160/500 - (32%)

  Fly   156 CEAKP---------IEVAVPQQEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYD 211
            |..||         ||..|..:|:.|                              ::|.|.||
Zfish     7 CRIKPEDTEQQIDLIEENVASKEEEH------------------------------HVKVEEKY- 40

  Fly   212 LATGIESSRKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVK 276
              ..|..|..:..:....||.|.:.|...|.|.:||:.|        |.|:|.|
Zfish    41 --LKIHMSMIHTGEKSLTCTQCGKSFSQLSNLNKHMKIH--------TGEKPFT----------- 84

  Fly   277 CNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQ 341
            |..||:.|........|.:||..|      .|.|
Zfish    85 CTQCGKSFIQSSSLNLHMMIHTGE------KPFT------------------------------- 112

  Fly   342 NTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIH 406
                                |..|...|...:.|.:|...|..|:.|.||.|....:.:...::|
Zfish   113 --------------------CTQCGKSFIQSSSLNLHMRIHTGEKPFRCTQCGKSFSQSSSLNLH 157

  Fly   407 FQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDF 471
            .:..             |..:.|.|..|...|..:..|.:|  ...|       .|:| ...|..
Zfish   158 MRIH-------------TGKKPFTCTQCGKSFNQSSNLNQH--MKIH-------TGEK-PFTCIQ 199

  Fly   472 CDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGV 536
            |..:|         |:..:||...|    .:||.   :.:.|..|||.::|||.|..|:|.|.|.
Zfish   200 CGKSF---------SQSSNLNHHMR----IHTGE---KPFTCTRCGKGFSQSSSLNLHMRIHTGE 248

  Fly   537 KPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECE 601
            |||.|.:  |.:.|. |...:|...|.|||.|.|:|..|.|.|:|......|:..|.||:.|:|.
Zfish   249 KPFRCTQ--CGKSFG-RSSQHDIHMKSHTGVREYVCFECEKTFITSGELKLHQRNHAGEKPYKCS 310

  Fly   602 ECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIR 646
            .|.|||.:::.||.|:|.|||||||.|..|.|.|.|......|.|
Zfish   311 HCDKRFNQSEHLKRHERTHTGEKPYMCSHCNKRFSQLPHLKTHER 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275370	5/19 (26%)
		C2H2 Zn finger	431..453	CDD:275368	5/21 (24%)
		COG5048	<450..647	CDD:227381	70/196 (36%)
		C2H2 Zn finger	469..490	CDD:275368	4/20 (20%)
		C2H2 Zn finger	513..564	CDD:275368	21/50 (42%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:463886	15/24 (63%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
zmp:0000001228	XP_073800154.1	None