DRSC/TRiP Functional Genomics Resources

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Protein Alignment topi and ZNF74

DIOPT Version :10

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:NP_003417.2 Gene:ZNF74 / 7625 HGNCID:13144 Length:644 Species:Homo sapiens


Alignment Length:709 Identity:158/709 - (22%)
Similarity:229/709 - (32%) Gaps:219/709 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 LPMPTDVVVERTLADPA--FKQILQEADGKKGFDPQA---EQMKIRDFLAGVTSSKM----TTEQ 119
            :|.|.......:..|||  .|:.|::..| .|. |:|   |.:..:|.....|..:.    :.::
Human     3 IPAPEPEKTALSSQDPALSLKENLEDISG-WGL-PEARSKESVSFKDVAVDFTQEEWGQLDSPQR 65

  Fly   120 SVF----------------------------HGSRSNSSASTVNRIKCPTCLVQFDAVAFQNHS- 155
            :::                            .|....|....|.|..||..  :..||..|... 
Human    66 ALYRDVMLENYQNLLALGPPLHKPDVISHLERGEEPWSMQREVPRGPCPEW--ELKAVPSQQQGI 128

  Fly   156 CEAKPIE------------------------VAVPQQEKPHLVPTVSAPPAPLSKP--ASERV-- 192
            |:.:|.:                        .|.|....|.:|..|.....||..|  |.:||  
Human   129 CKEEPAQEPIMERPLGGAQAWGRQAGALQRSQAAPWAPAPAMVWDVPVEEFPLRCPLFAQQRVPE 193

  Fly   193 ------IRENQVRLRRYIKDEMKYDLATGIESS-------------RKNAAKGPNE--CTMCDRK 236
                  .|:|........|...:  |..|..:|             ::.|..|..|  |..|.:.
Human   194 GGPLLDTRKNVQATEGRTKAPAR--LCAGENASTPSEPEKFPQVRRQRGAGAGEGEFVCGECGKA 256

  Fly   237 FVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEH 301
            |..:|.|..|...|:.:                   ...||:.||:.|........|..||..| 
Human   257 FRQSSSLTLHRRWHSRE-------------------KAYKCDECGKAFTWSTNLLEHRRIHTGE- 301

  Fly   302 STMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCE 366
                                                          |..|          |..|.
Human   302 ----------------------------------------------KPFF----------CGECG 310

  Fly   367 YIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVC 431
            ..|:..:.|.||...|..||.::|:||:...:.:...|:|.:..             |..:.:.|
Human   311 KAFSCHSSLNVHQRIHTGERPYKCSACEKAFSCSSLLSMHLRVH-------------TGEKPYRC 362

  Fly   432 NVCELKF-ANTDLLQEHRCTSFHYFPRLNENGKKLLLP--CDFCDVNFEFAHDFLAHSE------ 487
            ..|...| ..|.|.:.||.          ..|:|   |  |..|...|........|.:      
Human   363 GECGKAFNQRTHLTRHHRI----------HTGEK---PYQCGSCGKAFTCHSSLTVHEKIHSGDK 414

  Fly   488 -------EKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEEN 545
                   ||..|.:.|....:.|..|. :.:.|..|||.::..::|..|.|.|.|.|||.|.|  
Human   415 PFKCSDCEKAFNSRSRLTLHQRTHTGE-KPFKCADCGKGFSCHAYLLVHRRIHSGEKPFKCNE-- 476

  Fly   546 CDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRA 610
            |.:.|:....|..| |:.||||:|:.|..|.|.|...|....|:.||.||:.|:|.|||:.|.:.
Human   477 CGKAFSSHAYLIVH-RRIHTGEKPFDCSQCWKAFSCHSSLIVHQRIHTGEKPYKCSECGRAFSQN 540

  Fly   611 DALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLET 669
            ..|..||:||:|||.:.|..|.:.|.......:|.|. ||.   ...|.:|..|..|.|
Human   541 HCLIKHQKIHSGEKSFKCEKCGEMFNWSSHLTEHQRL-HSE---GKPLAIQFNKHLLST 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275370 6/19 (32%)
C2H2 Zn finger 277..297 CDD:275370 5/19 (26%)
C2H2 Zn finger 431..453 CDD:275368 7/22 (32%)
COG5048 <450..647 CDD:227381 65/211 (31%)
C2H2 Zn finger 469..490 CDD:275368 5/33 (15%)
C2H2 Zn finger 513..564 CDD:275368 19/50 (38%)
C2H2 Zn finger 541..561 CDD:275368 6/19 (32%)
C2H2 Zn finger 572..592 CDD:275368 6/19 (32%)
C2H2 Zn finger 600..620 CDD:275368 8/19 (42%)
zf-H2C2_2 612..637 CDD:463886 11/24 (46%)
C2H2 Zn finger 628..646 CDD:275368 4/17 (24%)
ZNF74NP_003417.2 KRAB 43..103 CDD:214630 3/59 (5%)
COG5048 <248..395 CDD:227381 45/248 (18%)
C2H2 Zn finger 250..270 CDD:275368 6/19 (32%)
C2H2 Zn finger 278..298 CDD:275368 5/19 (26%)
C2H2 Zn finger 306..326 CDD:275368 6/19 (32%)
COG5048 <331..511 CDD:227381 54/209 (26%)
C2H2 Zn finger 334..354 CDD:275368 5/19 (26%)
C2H2 Zn finger 362..382 CDD:275368 7/29 (24%)
C2H2 Zn finger 390..410 CDD:275368 4/19 (21%)
C2H2 Zn finger 418..438 CDD:275368 4/19 (21%)
C2H2 Zn finger 446..466 CDD:275368 7/19 (37%)
C2H2 Zn finger 474..494 CDD:275368 7/22 (32%)
C2H2 Zn finger 502..522 CDD:275368 6/19 (32%)
zf-H2C2_2 514..539 CDD:463886 11/24 (46%)
C2H2 Zn finger 530..550 CDD:275368 8/19 (42%)
C2H2 Zn finger 558..578 CDD:275368 5/20 (25%)

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