DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment topi and YY1

DIOPT Version :10

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:NP_003394.1 Gene:YY1 / 7528 HGNCID:12856 Length:414 Species:Homo sapiens


Alignment Length:114 Identity:43/114 - (37%)
Similarity:61/114 - (53%) Gaps:8/114 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   537 KPFVCQEENCDRKFTIRPDLNDHIRKCHT-GERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYEC 600
            :...|..:.|.:.|.....:..|:   || |.|.::|..|||.|:..|...:|:|:|.||:.::|
Human   294 RTIACPHKGCTKMFRDNSAMRKHL---HTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQC 355

  Fly   601 --EECGKRFYRADALKNHQRIHTGEKPYSCLF--CTKTFRQRGDRDKHI 645
              |.|||||.....|:.|.|||||::||.|.|  |.|.|.|..:...||
Human   356 TFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHI 404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275370
C2H2 Zn finger 277..297 CDD:275370
C2H2 Zn finger 431..453 CDD:275368
COG5048 <450..647 CDD:227381 43/114 (38%)
C2H2 Zn finger 469..490 CDD:275368
C2H2 Zn finger 513..564 CDD:275368 4/26 (15%)
C2H2 Zn finger 541..561 CDD:275368 4/19 (21%)
C2H2 Zn finger 572..592 CDD:275368 8/19 (42%)
C2H2 Zn finger 600..620 CDD:275368 10/21 (48%)
zf-H2C2_2 612..637 CDD:463886 14/26 (54%)
C2H2 Zn finger 628..646 CDD:275368 8/20 (40%)
YY1NP_003394.1 Interaction with the SMAD1/SMAD4 complex. /evidence=ECO:0000269|PubMed:15329343 1..170
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 33..81
Gly-rich region involved in interaction with HCFC1. /evidence=ECO:0000269|PubMed:20805357 116..260
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 157..203
Involved in nuclear matrix association. /evidence=ECO:0000269|PubMed:9493912 257..341 14/49 (29%)
COG5048 <268..407 CDD:227381 43/114 (38%)
Binding to DNA. /evidence=ECO:0000269|PubMed:18950698 295..414 43/113 (38%)
C2H2 Zn finger 298..320 CDD:275368 5/24 (21%)
C2H2 Zn finger 327..347 CDD:275368 8/19 (42%)
Involved in repression of activated transcription 333..371 14/37 (38%)
C2H2 Zn finger 355..377 CDD:275368 10/21 (48%)
Involved in masking transactivation domain 371..397 13/25 (52%)
C2H2 Zn finger 385..407 CDD:275368 8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.