DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and Zfp40

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_038947408.1	Gene:	Zfp40 / 690661	RGDID:	1593410	Length:	828	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	122/478 - (25%)
Similarity:	188/478 - (39%)	Gaps:	109/478 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 GIESSRK-NAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCN 278
            |:::..| :..:.|.||..|.:.|...|.|..|...|.                ...||   :||
  Rat   353 GLKNHHKIHGGERPYECKQCSKSFYTLSHLENHYRTHR----------------RQKLH---RCN 398

  Fly   279 SCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNT 343
            .||:.........||..||..|.:.:           .|:.::..:....|        .::|..
  Rat   399 ECGKSLSSSSGLQRHQRIHRGEKAYI-----------CAECDKCFIQKSQL--------KTHQKI 444

  Fly   344 NPPKK-----EMFSSLILGSVL-------------QCEFCEYIFADIAELLVHSASHVAERRFEC 390
            :..:|     |...|..:||.|             :|..|...|...|.|..|...|..|:.::|
  Rat   445 HTGEKSYKCSECEKSFTVGSSLRIHQRIHTGEKPYKCSECHKCFIQQAHLRRHQKIHTGEKPYKC 509

  Fly   391 TACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYF 455
            :.|:.......:..:|.:..             |..:.:.|:.|:..|.....|::|:
  Rat   510 SECEKSFTVGSDLRMHQKIH-------------TGEKPYKCSDCDKCFIQKAKLKKHQ------- 554

  Fly   456 PRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKK----------------REKETRNTG 504
             |::...|.  ..|..|:..|....|...| ::.|..:|.                |.....:||
  Rat   555 -RIHTGEKP--YKCSECEKCFTVVSDLRTH-QKIHTGEKPYKCSECDKCFIRKANLRRHHRIHTG 615

  Fly   505 AGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERP 569
            .   :.|.|..|||.:.|.::|..|.|.|.|.||:.|:   |.:.|::..||..| :||||||:|
  Rat   616 E---KPYKCSDCGKCFIQKANLRTHERIHTGEKPYKCE---CGKSFSVGSDLRKH-QKCHTGEKP 673

  Fly   570 YLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKT 634
            |.|..|.|.|:..:...:|:.||.||:.|:|.:|||.|.:...|:.||:||||||||.|..|.|.
  Rat   674 YKCSECHKCFIRKAHLRRHQRIHTGEKPYKCSDCGKCFIQKANLRTHQKIHTGEKPYKCSDCDKC 738

  Fly   635 FRQRGDRDKHIRARHSHLDANSR 657
            |.|:    .|:|. |..|....:
  Rat   739 FIQK----DHLRT-HQRLHTGEK 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	431..453	CDD:275368	5/21 (24%)
		COG5048	<450..647	CDD:227381	71/212 (33%)
		C2H2 Zn finger	469..490	CDD:275368	5/20 (25%)
		zf-C2H2	511..533	CDD:278523	9/21 (43%)
		C2H2 Zn finger	513..564	CDD:275368	19/50 (38%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	15/25 (60%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		zf-H2C2_2	585..609	CDD:290200	11/23 (48%)
		zf-C2H2	598..620	CDD:278523	9/21 (43%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:290200	15/24 (63%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
Zfp40	XP_038947408.1	KRAB	73..>115	CDD:214630
		C2H2 Zn finger	257..277	CDD:275368
		C2H2 Zn finger	285..305	CDD:275368
		COG5048	309..709	CDD:227381	99/424 (23%)
		C2H2 Zn finger	313..333	CDD:275368
		C2H2 Zn finger	341..361	CDD:275368	2/7 (29%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		C2H2 Zn finger	425..445	CDD:275368	3/27 (11%)
		C2H2 Zn finger	453..473	CDD:275368	5/19 (26%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
		C2H2 Zn finger	509..529	CDD:275368	3/19 (16%)
		C2H2 Zn finger	537..557	CDD:275368	6/27 (22%)
		C2H2 Zn finger	565..585	CDD:275368	5/20 (25%)
		C2H2 Zn finger	593..613	CDD:275368	1/19 (5%)
		C2H2 Zn finger	621..641	CDD:275368	8/19 (42%)
		C2H2 Zn finger	650..668	CDD:275368	6/21 (29%)
		C2H2 Zn finger	676..696	CDD:275368	5/19 (26%)
		C2H2 Zn finger	704..724	CDD:275368	8/19 (42%)
		zf-H2C2_2	716..741	CDD:404364	15/24 (63%)
		C2H2 Zn finger	732..752	CDD:275368	8/24 (33%)
		zf-H2C2_2	744..768	CDD:404364	4/14 (29%)
		C2H2 Zn finger	760..780	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910