DRSC/TRiP Functional Genomics Resources

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Protein Alignment topi and IKZF5

DIOPT Version :9

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:NP_001258769.1 Gene:IKZF5 / 64376 HGNCID:14283 Length:419 Species:Homo sapiens


Alignment Length:300 Identity:62/300 - (20%)
Similarity:106/300 - (35%) Gaps:103/300 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   541 CQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGK 605
            |:..|...|.|.|  |.:||| .||||:|:.|.:|.    ..|.:.:|                 
Human    84 CRYCNYASKGTAR--LIEHIR-IHTGEKPHRCHLCP----FASAYERH----------------- 124

  Fly   606 RFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARH--------------------- 649
                   |:.|.|.|||||||.|..|:.....|.:...|.|.:|                     
Human   125 -------LEAHMRSHTGEKPYKCELCSFRCSDRSNLSHHRRRKHKMVPIKGTRSSLSSKKMWGVL 182

  Fly   650 ----SHLDANSRLMMQMQKFQLETAAAQKAQSHN------PEQQDNDVAGGASTSDVPSGSGFMS 704
                |:|..:.|.::.:..   .:...||....|      |..|.:.....|.|:  |:|     
Human   183 QKKTSNLGYSRRALINLSP---PSMVVQKPDYLNDFTHEIPNIQTDSYESMAKTT--PTG----- 237

  Fly   705 TEPSVAEMQYSITPEQQEEMVCVPIDEVNNSFFMSHYMQAVPMEEDGSGQHIIVFEQPGQNMDMM 769
                      .:..:.||.||..|:::::.   ::..:.::|.|           .|...:.|::
Human   238 ----------GLPRDPQELMVDNPLNQLST---LAGQLSSLPPE-----------NQNPASPDVV 278

  Fly   770 SIYDQQ--QVGEPMHESGVPKRPAEENARVVVVKNNPTKP 807
            ...|::  .:.:|..::.|....|.     :...::||.|
Human   279 PCPDEKPFMIQQPSTQAVVSAVSAS-----IPQSSSPTSP 313

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275368
C2H2 Zn finger 277..297 CDD:275368
C2H2 Zn finger 431..453 CDD:275368
COG5048 <450..647 CDD:227381 32/105 (30%)
C2H2 Zn finger 469..490 CDD:275368
zf-C2H2 511..533 CDD:278523
C2H2 Zn finger 513..564 CDD:275368 9/22 (41%)
C2H2 Zn finger 541..561 CDD:275368 7/19 (37%)
zf-H2C2_2 555..581 CDD:290200 11/25 (44%)
C2H2 Zn finger 572..592 CDD:275368 4/19 (21%)
zf-H2C2_2 585..609 CDD:290200 1/23 (4%)
zf-C2H2 598..620 CDD:278523 3/21 (14%)
C2H2 Zn finger 600..620 CDD:275368 3/19 (16%)
zf-H2C2_2 612..637 CDD:290200 12/24 (50%)
C2H2 Zn finger 628..646 CDD:275368 4/17 (24%)
IKZF5NP_001258769.1 C2H2 Zn finger 84..104 CDD:275368 9/22 (41%)
zf-H2C2_2 96..121 CDD:404364 13/31 (42%)
C2H2 Zn finger 112..132 CDD:275368 7/47 (15%)
zf-H2C2_2 124..148 CDD:404364 13/47 (28%)
C2H2 Zn finger 140..158 CDD:275368 4/17 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 223..247 7/40 (18%)
PHA03269 251..>361 CDD:165527 11/81 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..356 10/67 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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