DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and RREB1

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001003699.1	Gene:	RREB1 / 6239	HGNCID:	10449	Length:	1742	Species:	Homo sapiens

Alignment Length:	969	Identity:	183/969 - (18%)
Similarity:	300/969 - (30%)	Gaps:	336/969 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 RSNSSASTVNR----------IKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAP 180
            :|.||||:::|          .||..|     ..:|..:....:.:::    .||.....|.:||
Human   104 KSLSSASSLDRHMLVHSGERPYKCTVC-----GQSFTTNGNMHRHMKI----HEKDPNSATATAP 159

  Fly   181 PAPLSKP--ASERVI-------RENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNECTMCDRK 236
            |:||.:.  :|:|.:       ||:....::.::|....||        :..|.....|.:|.::
Human   160 PSPLKRRRLSSKRKLSHDAESEREDPAPAKKMVEDGQSGDL--------EKKADEVFHCPVCFKE 216

  Fly   237 FVHASGLVRHMEKHA-----LDL---------------------IPSQTSEQPH-----TIPAAG 270
            ||...||..|||.|:     .|:                     :|.....:|.     :|| ||
Human   217 FVCKYGLETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIP-AG 280

  Fly   271 LHVV-------------------------------VKCNSCGRIFYDPQVA--FRHGLIHDSEHS 302
            .|.:                               ..|::|.:.|  |.:.  ..|...|.:...
Human   281 FHDLGFTDFSCRKFPRISQAWCETNLRRCISEQHRFVCDTCDKAF--PMLCSLALHKQTHVAADQ 343

  Fly   303 TMRQSPMTQVPSNRADFNELL-LDG-------------EMLIDNDPAFATSNQN---------TN 344
            ...:...|.:|.:..|....| |.|             |.|.|::.|.......         ||
Human   344 GQEKPQATPLPGDALDQKGFLALLGLQHTKDVRPAPAEEPLPDDNQAIQLQTLKCQLPQDPGCTN 408

  Fly   345 -------------------PPKKEMFSSLIL-----GSVLQCEFCEYI----------FADIAEL 375
                               |..|:....|.|     |.::|.:....:          .|||.::
Human   409 LLSLSPFEAASLGGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQI 473

  Fly   376 LVHSAS-----------------------H---------VAERRFECTACDIQMNTAKEASIHFQ 408
            |..:||                       |         |..|....|:....:..|::||
Human   474 LKMAASAPPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQAS---- 534

  Fly   409 TDCI----------FMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGK 463
            ..||          .::.::.:.                 :|..|||....|..|...||:....
Human   535 PGCISPSLPPPPLKLLKGSVEAA-----------------SNAHLLQSKSGTQPHAATRLSLQQP 582

  Fly   464 KLLLPCDFCDVNFEFAHD-----FLAHSEEKHLNKKKREKET---------RNTGAGRIRQYLCD 514
            :..||.. .::..:...|     .|..|.|..:.::..|.|.         :.|.|.|...|.|.
Human   583 RAELPGQ-PEMKTQLEQDSIIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVLYPCR 646

  Fly   515 ICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRF 579
            .|.:.:..|..|..|:|.|.|:.|:.|  ..||.....:..|..|:| .|:|||||:|.:|...|
Human   647 FCNQVFAFSGVLRAHVRSHLGISPYQC--NICDYIAADKAALIRHLR-THSGERPYICKICHYPF 708

  Fly   580 LTGSVFYQH-RLIHRGERRYE-------------------------CEECGKRFYRADALKNHQR 618
            ...:...:| |..|....|.:                         |..||:......||:.|.|
Human   709 TVKANCERHLRKKHLKATRKDIEKNIEYVSSSAAELVDAFCAPDTVCRLCGEDLKHYRALRIHMR 773

  Fly   619 I---------HTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLETAAAQK 674
            .         |.|.||:.|..|:..|..:.:...||..:|.|:.........:....|..|.|..
Human   774 THCGRGLGGGHKGRKPFECKECSAAFAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGPAEAPA 838

  Fly   675 AQSHNPEQQDNDVAGG---ASTSDVPSGSGFM---STEPSVAEMQYSITPE-------------Q 720
            |::....:.....|.|   ..|:.:...:||:   .|:|....:...:.|.             .
Human   839 AEASGRGEDSGCAALGDCKPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPLDFS 903

  Fly   721 QEEMVCVPIDEVNNSFF----MSHY---MQAV-----------------------PMEEDGSGQH 755
            |:.:..|.:.:.|.||.    :..|   |:.:                       |.||.||.:.
Human   904 QKGLALVQVKQENISFLSPSSLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEEAGSSEQ 968

  Fly   756 IIVFEQPGQNMDM----MSIYDQQQVGEPMHESGVPKRPAEENARVVVVKNNPTKPIFS 810
            ......||.::.:    ..|.:......|......|.:|.:...::.|       ||:|
Human   969 PSPCPAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQLAV-------PIYS 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	9/19 (47%)
		C2H2 Zn finger	277..297	CDD:275368	5/21 (24%)
		C2H2 Zn finger	431..453	CDD:275368	5/21 (24%)
		COG5048	<450..647	CDD:227381	60/245 (24%)
		C2H2 Zn finger	469..490	CDD:275368	4/25 (16%)
		zf-C2H2	511..533	CDD:278523	7/21 (33%)
		C2H2 Zn finger	513..564	CDD:275368	15/50 (30%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		zf-H2C2_2	555..581	CDD:290200	12/25 (48%)
		C2H2 Zn finger	572..592	CDD:275368	5/20 (25%)
		zf-H2C2_2	585..609	CDD:290200	7/49 (14%)
		zf-C2H2	598..620	CDD:278523	7/55 (13%)
		C2H2 Zn finger	600..620	CDD:275368	7/28 (25%)
		zf-H2C2_2	612..637	CDD:290200	11/33 (33%)
		C2H2 Zn finger	628..646	CDD:275368	4/17 (24%)
RREB1	NP_001003699.1	COG5048	<64..246	CDD:227381	37/158 (23%)
		C2H2 Zn finger	68..88	CDD:275368
		C2H2 Zn finger	99..119	CDD:275368	6/14 (43%)
		zf-H2C2_2	111..136	CDD:290200	5/29 (17%)
		C2H2 Zn finger	127..147	CDD:275368	3/28 (11%)
		C2H2 Zn finger	211..230	CDD:275368	8/18 (44%)
		C2H2 Zn finger	237..253	CDD:275368	1/15 (7%)
		C2H2 Zn finger	645..665	CDD:275368	6/19 (32%)
		C2H2 Zn finger	673..693	CDD:275368	6/22 (27%)
		zf-H2C2_2	685..709	CDD:290200	11/24 (46%)
		C2H2 Zn finger	701..719	CDD:275368	4/17 (24%)
		C2H2 Zn finger	755..775	CDD:275368	7/19 (37%)
		C2H2 Zn finger	792..814	CDD:275368	5/21 (24%)
		C2H2 Zn finger	1248..1268	CDD:275368
		zf-H2C2_2	1260..1285	CDD:290200
		C2H2 Zn finger	1276..1297	CDD:275368
		TMEM119	<1467..1531	CDD:292352
		C2H2 Zn finger	1569..1589	CDD:275368
		zf-H2C2_2	1581..1605	CDD:290200
		zf-C2H2	1595..1617	CDD:278523
		C2H2 Zn finger	1597..1617	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910