DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and Hic2

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_849253.2	Gene:	Hic2 / 58180	MGIID:	1929869	Length:	619	Species:	Mus musculus

Alignment Length:	722	Identity:	152/722 - (21%)
Similarity:	225/722 - (31%)	Gaps:	252/722 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VGPAGALPMPTDVVVERTLADPAFKQILQEADGKKGFDPQAEQMKIRDFLAGVTSSKMTTEQSVF 122
            :||...||..:             ||:|.          |..|.:.:.||..|.   :..|.|:|
Mouse    19 MGPDMELPSHS-------------KQLLL----------QLNQQRAKGFLCDVI---IMVENSIF 57

  Fly   123 HGSRSNSSASTV---------NRIKCPTCLVQFDAVAFQ--------------------NHS--- 155
            ...::..:||::         |.|...|.:|  .:..||                    |.|
Mouse    58 RAHKNVLAASSIYFKSLVLHDNLINLDTDMV--SSTVFQQILDFIYTGKLLPSDQPSEPNFSTLL 120

  Fly   156 --------------CE------AKPI--------------------EVAVPQQEKPHLVPTVSAP 180
                          |.      .||.                    ..:|.|...|.||......
Mouse   121 TAASYLQLPELAALCRRKLKRAGKPFGPGRVGTAGIGRPTRSQRLSTASVIQARFPGLVDVRKGH 185

  Fly   181 PAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNECTM----CDRKFVHAS 241
            |||...|.:            :...||:....:|. ||:......||....|    |......:|
Mouse   186 PAPQELPQA------------KGSDDELFLGTSTQ-ESTHGLGLGGPAGGEMGLGGCSTSTNGSS 237

  Fly   242 G-----LVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEH 301
            |     |...:.|.:..|.|  |:..||..|.                 ||      ..:.||:.
Mouse   238 GGCEQELGLDLSKKSPPLPP--TTPGPHLTPE-----------------DP------AQLSDSQR 277

  Fly   302 STMRQSPMTQVP-SNRADFNEL-------------------LLDGEMLIDNDP--AFATSNQNTN 344
            .:...:..:.:| .|.|.|.||                   ||:|:   ...|  :...|.:..:
Mouse   278 ESPAPTSTSALPVGNSASFVELGATPEEPMDVEGAEENHLSLLEGQ---GGQPRKSLRHSARKKD 339

  Fly   345 PPKKE-----MFSSLILGSVLQCEFCE----------YIFADIAELLVHSASHVAERRFECT--- 391
            ..|||     .|.....||...|...|          .:.|..|.....|||: .|:.|.|.
Mouse   340 WNKKEPVAGSPFDRRETGSKGSCPGEEGEGTGDRVPNGVLASSAGGGGPSASY-GEQSFPCKEEE 403

  Fly   392 ------ACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCT 450
                  :.|...:.::..|.|.....::.:|...:::.. ...:||..|...|.:::.|..|..|
Mouse   404 ENGKDGSEDSGQSGSEGGSGHTGAHYVYRQEGYETVSYG-DNVYVCIPCAKGFPSSEQLNAHVET 467

  Fly   451 SFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDI 515
                                              |:||:...|   |:....||:|...:...|:
Mouse   468 ----------------------------------HTEEELFIK---EEGAYETGSGGAEEEAEDL 495

  Fly   516 CGKS--YTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKR 578
            ...|  ||..|            :||.|..  |::.:.....|..| .|.|...||:.|.:|||.
Mouse   496 STPSAAYTADS------------RPFKCSV--CEKTYKDPATLRQH-EKTHWLTRPFPCNICGKM 545

  Fly   579 FLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDK 643
            |.......:|...|.|.:.:.|:|||.||.|...|..|.|:|:|||||.|..|...|.|:.:...
Mouse   546 FTQRGTMTRHMRSHLGLKPFACDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLIS 610

  Fly   644 HIRARHS 650
            |:|...|
Mouse   611 HLRMHTS 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	5/28 (18%)
		C2H2 Zn finger	277..297	CDD:275368	2/19 (11%)
		C2H2 Zn finger	431..453	CDD:275368	6/21 (29%)
		COG5048	<450..647	CDD:227381	53/198 (27%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		zf-C2H2	511..533	CDD:278523	5/23 (22%)
		C2H2 Zn finger	513..564	CDD:275368	12/52 (23%)
		C2H2 Zn finger	541..561	CDD:275368	4/19 (21%)
		zf-H2C2_2	555..581	CDD:290200	11/25 (44%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		zf-H2C2_2	585..609	CDD:290200	9/23 (39%)
		zf-C2H2	598..620	CDD:278523	10/21 (48%)
		C2H2 Zn finger	600..620	CDD:275368	10/19 (53%)
		zf-H2C2_2	612..637	CDD:290200	12/24 (50%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
Hic2	NP_849253.2	BTB	40..140	CDD:279045	17/104 (16%)
		BTB	47..141	CDD:197585	15/98 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..293		28/150 (19%)
		Binding to CtBP. /evidence=ECO:0000250	247..249		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..426		24/122 (20%)
		C2H2 Zn finger	448..468	CDD:275368	6/53 (11%)
		zf-C2H2	509..531	CDD:278523	6/24 (25%)
		C2H2 Zn finger	511..531	CDD:275368	5/22 (23%)
		zf-C2H2	537..559	CDD:278523	6/21 (29%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		zf-H2C2_2	552..576	CDD:290200	9/23 (39%)
		COG5048	563..>617	CDD:227381	22/53 (42%)
		C2H2 Zn finger	567..587	CDD:275368	10/19 (53%)
		zf-H2C2_2	580..604	CDD:290200	12/23 (52%)
		C2H2 Zn finger	595..615	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910