Protein Alignment topi and LOC5667959

DIOPT Version :10

• Sequence 1: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: XP_061509891.1
• Gene: LOC5667959 / 5667959
• VectorBaseID: AGAMI1_014095
• Length: 440
• Species: Anopheles gambiae
• Alignment Length: 517
• Identity: 106/517 - (20%)
• Similarity: 173/517 - (33%)
• Gaps: 141/517 - (27%)

  Fly   168 QEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNECTM 232
            ||:..|:|........|:   .|.|.|...::|.|  .|.::..:......|.:.:|...|.|..
Mosquito    18 QEEKQLMPITKIIHPSLT---IEDVRRFTGIQLHR--NDALRLAMCLECFDSLRRSADFRNACIR 77

  Fly   233 CDRKF----VHASGLVRH-MEKHALDLIPSQT--------------------SEQPHTIPAAGLH 272
            .:..|    :..|....| :.|:..|:.|.:.                    ::...|:|:   |
Mosquito    78 NEPTFHQMCIGPSTSENHGLAKNTQDVDPLEVQIEVLRVETELFDEDTFVNGNQNTSTVPS---H 139

  Fly   273 --VVVKCN-----SCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLI 330
              :..|.|     :|..|...|           :|..|:||:|                |.:...
Mosquito   140 QEIATKNNDQYSANCIAINEPP-----------AERLTVRQAP----------------DSDKET 177

  Fly   331 DNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDI 395
            .||..|......|:|.:                       |..:.||.      ::|........
Mosquito   178 PNDDDFTWHESETDPAR-----------------------DGKQKLVR------KKRPNRKRAGA 213

  Fly   396 QMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQ--EHRCTSFHYFPRL 458
            :..|.::.:          |||..|.....|...:|::|....:|.:..|  .|..||
Mosquito   214 EQITRRDPA----------REAKSSSTGGRSARVLCSICGTFVSNLNFHQNYHHAKTS------- 261

  Fly   459 NENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQS 523
                  :.|.|..|........:...|....||               :|.:..|:||||.:|.:
Mosquito   262 ------IKLSCPHCPAKITHQKNLTRHINTVHL---------------KIVEKTCEICGKEFTTN 305

  Fly   524 SHLWQHL-RFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQ 587
            :....|: ..|...:|..|..  |.:||....:|..|....|..:| |.|.:|.|.|.:..:...
Mosquito   306 NSYVSHMDSQHYTGEPLECSV--CGKKFRHATNLRRHTYAVHNAKR-YCCGICDKSFKSSGLLNI 367

  Fly   588 HRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARH 649
            |:.:|...:.|.|.:|.|||....|.|.|:..|:|.. :.|..|.|::|.:.....|:|..|
Mosquito   368 HQRVHSDAQPYACSQCPKRFKSRFARKTHELTHSGVL-FKCTLCEKSYRYKSLLSMHMRKMH 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370	4/24 (17%)
		C2H2 Zn finger	277..297	CDD:275370	4/24 (17%)
		C2H2 Zn finger	431..453	CDD:275368	7/23 (30%)
		COG5048	<450..647	CDD:227381	49/197 (25%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		C2H2 Zn finger	513..564	CDD:275368	15/51 (29%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:463886	8/24 (33%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
LOC5667959	XP_061509891.1	None