DRSC/TRiP Functional Genomics Resources

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Protein Alignment topi and ZNF692

DIOPT Version :9

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:XP_011542525.1 Gene:ZNF692 / 55657 HGNCID:26049 Length:625 Species:Homo sapiens


Alignment Length:595 Identity:124/595 - (20%)
Similarity:186/595 - (31%) Gaps:206/595 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   159 KPIEVAVPQQEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNA 223
            :|....||.|....|:|.::|...|:                                       
Human   204 RPHGAVVPPQGAAGLLPALAARQVPV--------------------------------------- 229

  Fly   224 AKGP----NECTMCDRKFVHASGL---------------VRHMEKHALDLIPSQTSEQPHTIPAA 269
              ||    ..|.:|.|:.....||               ..|.......|.|: .||.|.  ||:
Human   230 --GPVHFFRLCPLCSRECSLVPGLRGPGGQDGGLVWECSAGHTFSWGPSLSPT-PSEAPK--PAS 289

  Fly   270 GLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDP 334
            ..| ..:.:.|.......::|..     :|||....|.  .::||:..|...||        ..|
Human   290 LPH-TTRRSWCSEATSGQELADL-----ESEHDERTQE--ARLPSSEPDAPRLL--------PSP 338

  Fly   335 AFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNT 399
            ...|..:...||.....||.:....|                  |||.::.|........:|...
Human   339 VTCTPKEGETPPAPAALSSPLAVPAL------------------SASSLSSRAPPPAEVRVQPQL 385

  Fly   400 AKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKK 464
            ::......||      ||:.|..           .:.:.|.|....|.  |:.....|:.:..|:
Human   386 SRTPQAAQQT------EALASTG-----------SQAQSAPTPAWDED--TAQIGPKRIRKAAKR 431

  Fly   465 LLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRI---RQYLCDICGKSYTQSSHL 526
            .|:||||                               .|.|||   ||||           :|.
Human   432 ELMPCDF-------------------------------PGCGRIFSNRQYL-----------NHH 454

  Fly   527 WQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLI 591
            .::...||  |.|.|.|..|.:.|..:..|.:|: |.|:..|.|:|..|.:.|.|.|....||.|
Human   455 KKYQHIHQ--KSFSCPEPACGKSFNFKKHLKEHM-KLHSDTRDYICEFCARSFRTSSNLVIHRRI 516

  Fly   592 HRGERRYECEECGKRFYRADALKNHQRIH---TGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLD 653
            |.||:..:||.||....:..:|..|||.|   .....:.|.||.|.|.:.               
Human   517 HTGEKPLQCEICGFTCRQKASLNWHQRKHAETVAALRFPCEFCGKRFEKP--------------- 566

  Fly   654 ANSRLMMQMQKFQLETAAAQKAQSH-----NPEQQDNDVAGGASTSDVPSGSGFMSTE---PSVA 710
                          ::.||.:::||     .|::..:.......:...|...|  |:|   ||.:
Human   567 --------------DSVAAHRSKSHPALLLAPQESPSGPLEPCPSISAPGPLG--SSEGSRPSAS 615

  Fly   711 EMQYSITPEQ 720
            ....::.|:|
Human   616 PQAPTLLPQQ 625

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275368 6/34 (18%)
C2H2 Zn finger 277..297 CDD:275368 2/19 (11%)
C2H2 Zn finger 431..453 CDD:275368 4/21 (19%)
COG5048 <450..647 CDD:227381 56/202 (28%)
C2H2 Zn finger 469..490 CDD:275368 3/20 (15%)
zf-C2H2 511..533 CDD:278523 3/21 (14%)
C2H2 Zn finger 513..564 CDD:275368 12/50 (24%)
C2H2 Zn finger 541..561 CDD:275368 6/19 (32%)
zf-H2C2_2 555..581 CDD:290200 9/25 (36%)
C2H2 Zn finger 572..592 CDD:275368 7/19 (37%)
zf-H2C2_2 585..609 CDD:290200 10/23 (43%)
zf-C2H2 598..620 CDD:278523 8/21 (38%)
C2H2 Zn finger 600..620 CDD:275368 8/19 (42%)
zf-H2C2_2 612..637 CDD:290200 10/27 (37%)
C2H2 Zn finger 628..646 CDD:275368 5/17 (29%)
ZNF692XP_011542525.1 zf-C2H2 465..489 CDD:278523 8/24 (33%)
C2H2 Zn finger 467..489 CDD:275368 7/22 (32%)
COG5048 490..>591 CDD:227381 32/129 (25%)
zf-C2H2 495..517 CDD:278523 8/21 (38%)
C2H2 Zn finger 497..517 CDD:275368 7/19 (37%)
zf-H2C2_2 509..534 CDD:290200 10/24 (42%)
C2H2 Zn finger 525..545 CDD:275368 8/19 (42%)
C2H2 Zn finger 556..577 CDD:275368 7/49 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24390
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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