DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and ZNF331

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001073375.1	Gene:	ZNF331 / 55422	HGNCID:	15489	Length:	463	Species:	Homo sapiens

Alignment Length:	571	Identity:	131/571 - (22%)
Similarity:	201/571 - (35%)	Gaps:	197/571 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 DFLAGVTSSKMTTEQSV--FHGSRSNSS--ASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAV 165
            |..:...:..:.||:::  ...|:.||.  :.::.|                |..||.   .:..
Human    46 DLESAYENKSLPTEKNIHEIRASKRNSDRRSKSLGR----------------NWICEG---TLER 91

  Fly   166 PQQEKPH-----LVPTVSAPPAPLSKP--ASERVIRENQVRLRRYIKDEMK-----YDLATGIES 218
            ||:.:..     ::..|..|......|  ..:|..:||...    .||..|     |.|:   :.
Human    92 PQRSRGRYVNQMIINYVKRPATREGTPPRTHQRHHKENSFE----CKDCGKAFSRGYQLS---QH 149

  Fly   219 SRKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRI 283
            .:.:..:.|.||..|.:.|...:.|.:|.:.|        |.|:|:           :|..||:
Human   150 QKIHTGEKPYECKECKKAFRWGNQLTQHQKIH--------TGEKPY-----------ECKDCGK- 194

  Fly   284 FYDPQVAFRHG---LIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNP 345
                  |||.|   :||...|:       .:.|....|..:....|:.|        |.:|..:.
Human   195 ------AFRWGSSLVIHKRIHT-------GEKPYECKDCGKAFRRGDEL--------TQHQRFHT 238

  Fly   346 PKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTD 410
            .:|:          .:|:.|...|:.:.:|:.|...|..|:.:||..|
Human   239 GEKD----------YECKDCGKTFSRVYKLIQHKRIHSGEKPYECKDC----------------- 276

  Fly   411 CIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVN 475
                           .:.|:|        .:.|:|..|
Human   277 ---------------GKAFIC--------GSSLIQHKR--------------------------- 291

  Fly   476 FEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFV 540
                    .|:.||                    .|.|..|||::|:.::|.||.:.|.|.||..
Human   292 --------IHTGEK--------------------PYECQECGKAFTRVNYLTQHQKIHTGEKPHE 328

  Fly   541 CQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGK 605
            |:|  |.:.|.....|..| .:.||||:||.|..|||.|..|....||..||.||..|:|:||||
Human   329 CKE--CGKAFRWGSSLVKH-ERIHTGEKPYKCTECGKAFNCGYHLTQHERIHTGETPYKCKECGK 390

  Fly   606 RFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANS 656
            .|....:|..|:|||||.|||.|..|.|:|.......:|   :.:|..|.|
Human   391 AFIYGSSLVKHERIHTGVKPYGCTECGKSFSHGHQLTQH---QKTHSGAKS 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/22 (32%)
		C2H2 Zn finger	431..453	CDD:275368	4/21 (19%)
		COG5048	<450..647	CDD:227381	62/196 (32%)
		C2H2 Zn finger	469..490	CDD:275368	2/20 (10%)
		zf-C2H2	511..533	CDD:278523	9/21 (43%)
		C2H2 Zn finger	513..564	CDD:275368	18/50 (36%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	13/25 (52%)
		C2H2 Zn finger	572..592	CDD:275368	8/19 (42%)
		zf-H2C2_2	585..609	CDD:290200	13/23 (57%)
		zf-C2H2	598..620	CDD:278523	10/21 (48%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	14/24 (58%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
ZNF331	NP_001073375.1	KRAB	5..46	CDD:366587	131/571 (23%)
		COG5048	<32..284	CDD:227381	63/354 (18%)
		C2H2 Zn finger	133..153	CDD:275368	5/22 (23%)
		C2H2 Zn finger	161..181	CDD:275368	5/19 (26%)
		COG5048	185..441	CDD:227381	98/398 (25%)
		C2H2 Zn finger	189..209	CDD:275368	9/26 (35%)
		C2H2 Zn finger	217..237	CDD:275368	5/27 (19%)
		C2H2 Zn finger	245..265	CDD:275368	5/19 (26%)
		C2H2 Zn finger	273..293	CDD:275368	7/94 (7%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		C2H2 Zn finger	329..349	CDD:275368	6/22 (27%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..405	CDD:275368	9/19 (47%)
		C2H2 Zn finger	413..433	CDD:275368	5/22 (23%)
		C2H2 Zn finger	441..461	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000