DRSC/TRiP Functional Genomics Resources

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Protein Alignment topi and Zfp410

DIOPT Version :9

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:NP_659082.1 Gene:Zfp410 / 52708 MGIID:1289280 Length:478 Species:Mus musculus


Alignment Length:495 Identity:116/495 - (23%)
Similarity:184/495 - (37%) Gaps:118/495 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   328 MLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTA 392
            ||.|..|..|.|:       ||:.||.:|.|                |.|:......|.|.:...
Mouse    54 MLPDETPNHANSS-------KEVPSSAVLRS----------------LQVNVGPDGEETRAQTVQ 95

  Fly   393 CDIQMNTAKEASIHFQ-------TDCIFMREAIRSLNVT------LSRYFVCNVCELKFANTDLL 444
            ...:..|..|:....|       |..|.       ||:|      .:.:||....|.:.:..|.|
Mouse    96 KSPEFLTTPESPSLLQDLQPSDSTSFIL-------LNLTRAGLGSSAEHFVFVQDETEDSGADFL 153

  Fly   445 Q-EHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKR---EKETRNTGA 505
            . |...:|..:|.|:.                 |.|||.|..:....|.|..:   ..|..:.|:
Mouse   154 SAESTDSSIPWFLRVQ-----------------ELAHDSLIAATRAQLAKNAKTGSNGENVHLGS 201

  Fly   506 G------------RIRQYLCDI--CGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDL 556
            |            ..::..|.:  |.:::...:|...||:.|:..:.|:|..|.|.:.|.:...|
Mouse   202 GDGQPKDSGPLPQAEKKLKCTVEGCDRTFVWPAHFKYHLKTHRNERSFICPAEGCGKSFYVLQRL 266

  Fly   557 NDHIRKCHTGERPYLC--LVCGKRFLTGSVFYQHRLIHRGERRYECEE--CGKRFYRADALKNHQ 617
            ..|:| .|.||:|::|  ..|||:|.|......||.||.||:.:.||.  ||:.|....:|:.|.
Mouse   267 KVHMR-THNGEKPFMCHESGCGKQFTTAGNLKNHRRIHTGEKPFLCEAQGCGRSFAEYSSLRKHL 330

  Fly   618 RIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLETAAAQKAQSHNPEQ 682
            .:|:||||:.|..|.|||.|.|.|:.|:|..|               .||.|..:|:     .:|
Mouse   331 VVHSGEKPHQCQVCGKTFSQSGSRNVHMRKHH---------------LQLGTTGSQE-----QDQ 375

  Fly   683 QDNDVAGGASTSD--VP----------SGSGFMSTEPSVAEMQYSITPEQQEEMVCVPIDEVNNS 735
            ....:.|.:...|  ||          |..|..|...|.......:..|...|....|:..|.: 
Mouse   376 TAEPLMGSSLLEDASVPNKNLVSMNSQSSLGGESLNLSNTNSILGVDDEVLTERASRPLSSVPD- 439

  Fly   736 FFMSHYMQAVPMEEDGSGQHIIVFEQPGQNMDMMSIYDQQ 775
              ::|::..:..........::....|.:.::...:.::|
Mouse   440 --VTHHLVTMQSGRQSYEVSVLTAVNPQELLNQGDLTERQ 477

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275368
C2H2 Zn finger 277..297 CDD:275368
C2H2 Zn finger 431..453 CDD:275368 5/22 (23%)
COG5048 <450..647 CDD:227381 64/217 (29%)
C2H2 Zn finger 469..490 CDD:275368 5/20 (25%)
zf-C2H2 511..533 CDD:278523 5/23 (22%)
C2H2 Zn finger 513..564 CDD:275368 14/52 (27%)
C2H2 Zn finger 541..561 CDD:275368 6/19 (32%)
zf-H2C2_2 555..581 CDD:290200 12/27 (44%)
C2H2 Zn finger 572..592 CDD:275368 8/21 (38%)
zf-H2C2_2 585..609 CDD:290200 11/25 (44%)
zf-C2H2 598..620 CDD:278523 7/23 (30%)
C2H2 Zn finger 600..620 CDD:275368 7/21 (33%)
zf-H2C2_2 612..637 CDD:290200 12/24 (50%)
C2H2 Zn finger 628..646 CDD:275368 9/17 (53%)
Zfp410NP_659082.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 84..113 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 187..214 3/26 (12%)
SFP1 <189..300 CDD:227516 27/111 (24%)
C2H2 Zn finger 221..243 CDD:275368 5/21 (24%)
C2H2 Zn finger 251..273 CDD:275368 7/22 (32%)
zf-H2C2_2 265..292 CDD:372612 12/27 (44%)
C2H2 Zn finger 281..303 CDD:275368 8/21 (38%)
zf-H2C2_2 295..321 CDD:372612 10/25 (40%)
C2H2 Zn finger 311..333 CDD:275368 7/21 (33%)
zf-H2C2_2 325..350 CDD:372612 12/24 (50%)
C2H2 Zn finger 341..361 CDD:275368 10/19 (53%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24390
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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