DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and ZNF581

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_057619.1	Gene:	ZNF581 / 51545	HGNCID:	25017	Length:	197	Species:	Homo sapiens

Alignment Length:	159	Identity:	46/159 - (28%)
Similarity:	66/159 - (41%)	Gaps:	37/159 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 EKETRNTGA----GRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLN 557
            |:..|..||    |:.:.|.|.:|.:.:...|:|.:|...|..||||.|.
Human    69 EESQREPGASGAPGQKKCYSCPVCSRVFEYMSYLQRHSITHSEVKPFECD--------------- 118

  Fly   558 DHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIH--RGERRYECEECGKRFYRADALKNHQRIH 620
                            :|||.|...|...:|..||  .|.|.:.|..|.:||..|..|..|.|:|
Human   119 ----------------ICGKAFKRASHLARHHSIHLAGGGRPHGCPLCPRRFRDAGELAQHSRVH 167

  Fly   621 TGEKPYSCLFCTKTFRQRGDRDKHIRARH 649
            :||:|:.|..|.:.|.::....||.|.:|
Human   168 SGERPFQCPHCPRRFMEQNTLQKHTRWKH 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368
		COG5048	<450..647	CDD:227381	44/155 (28%)
		C2H2 Zn finger	469..490	CDD:275368
		zf-C2H2	511..533	CDD:278523	6/21 (29%)
		C2H2 Zn finger	513..564	CDD:275368	11/50 (22%)
		C2H2 Zn finger	541..561	CDD:275368	1/19 (5%)
		zf-H2C2_2	555..581	CDD:290200	4/25 (16%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		zf-H2C2_2	585..609	CDD:290200	9/25 (36%)
		zf-C2H2	598..620	CDD:278523	8/21 (38%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:290200	10/24 (42%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
ZNF581	NP_057619.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		C2H2 Zn finger	89..109	CDD:275368	5/19 (26%)
		zf-H2C2_2	101..126	CDD:404364	12/55 (22%)
		C2H2 Zn finger	117..137	CDD:275368	7/50 (14%)
		C2H2 Zn finger	147..167	CDD:275368	8/19 (42%)
		C2H2 Zn finger	175..193	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010