DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and ZNF117

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_056936.2	Gene:	ZNF117 / 51351	HGNCID:	12897	Length:	483	Species:	Homo sapiens

Alignment Length:	636	Identity:	147/636 - (23%)
Similarity:	219/636 - (34%)	Gaps:	212/636 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ERIVSHEELSRFFA--VGPAGALPMPTDVVVERTLADPAFKQILQEADGKKGFDPQAEQMKIR-- 104
            |.:..|..:..:||  :.|            |:.:.| :|:::......|.|:    |.:::|
Human     5 EMVAKHLVMFYYFAQHLWP------------EQNIRD-SFQKVTLRRYRKCGY----ENLQLRKG 52

  Fly   105 ------------DFLAGVTSSKMTTEQSVFHGSR--------SNSS----ASTVNR-IKCPTCLV 144
                        |: :|:.....||...:|..::        |||:    ..|.|: .||..|..
Human    53 CKSVVECKQHKGDY-SGLNQCLKTTLSKIFQCNKYVEVFHKISNSNRHKMRHTENKHFKCKECRK 116

  Fly   145 QFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEMK 209
            .|   ...:|..:.|.|:..|                                    .:.|.| .
Human   117 TF---CMLSHLTQHKRIQTRV------------------------------------NFYKCE-A 141

  Fly   210 YDLATGIESS-----RKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAA 269
            |..|....|:     |.:..:.|.:|..|.:.|...|.|:||...|        |.|:|:
Human   142 YGRAFNWSSTLNKHKRIHTGEKPYKCKECGKAFNQTSHLIRHKRIH--------TEEKPY----- 193

  Fly   270 GLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDP 334
                  ||..||:.|........|.:||..|           :|
Human   194 ------KCEECGKAFNQSSTLTTHNIIHTGE-----------IP--------------------- 220

  Fly   335 AFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNT 399
                                     .:||.|...|...::|..|...|..|:|:||..|....|.
Human   221 -------------------------YKCEKCVRAFNQASKLTEHKLIHTGEKRYECEECGKAFNR 260

  Fly   400 AKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKK 464
            :.:.:.|....             |..:.:.|..|...|..:..|..|:        |::...|.
Human   261 SSKLTEHKYIH-------------TGEKLYKCEECGKAFNQSSTLTTHK--------RIHSGEKP 304

  Fly   465 LLLPCDFCDVNF-EFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQ 528
              ..|:.|...| :|::  |...::.|..:|               .|.|:.|||::.|.|:|.:
Human   305 --YKCEECGKAFKQFSN--LTDHKKIHTGEK---------------PYKCEECGKAFNQLSNLTR 350

  Fly   529 HLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHR 593
            |...|.|.||:.|.|  |.:.|.....||.| :..||||.|:.|...||.|...|.....:.||.
Human   351 HKVIHTGEKPYKCGE--CGKAFNQSSALNTH-KIIHTGENPHKCRESGKVFHLSSKLSTCKKIHT 412

  Fly   594 GERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKH 644
            ||:.|:||||||.|.|:..|..|:|||||||||.|..|.|.|.|......|
Human   413 GEKLYKCEECGKAFNRSSTLIGHKRIHTGEKPYKCEECGKAFNQSSTLTTH 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..453	CDD:275368	5/21 (24%)
		COG5048	<450..647	CDD:227381	69/196 (35%)
		C2H2 Zn finger	469..490	CDD:275368	5/21 (24%)
		zf-C2H2	511..533	CDD:278523	9/21 (43%)
		C2H2 Zn finger	513..564	CDD:275368	19/50 (38%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	555..581	CDD:290200	12/25 (48%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		zf-H2C2_2	585..609	CDD:290200	12/23 (52%)
		zf-C2H2	598..620	CDD:278523	12/21 (57%)
		C2H2 Zn finger	600..620	CDD:275368	11/19 (58%)
		zf-H2C2_2	612..637	CDD:290200	15/24 (63%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
ZNF117	NP_056936.2	C2H2 Zn finger	111..131	CDD:275368	5/22 (23%)
		C2H2 Zn finger	139..159	CDD:275368	5/20 (25%)
		COG5048	163..>475	CDD:227381	111/420 (26%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		C2H2 Zn finger	195..215	CDD:275368	5/19 (26%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	251..271	CDD:275368	4/19 (21%)
		C2H2 Zn finger	279..299	CDD:275368	6/27 (22%)
		C2H2 Zn finger	307..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	7/22 (32%)
		C2H2 Zn finger	391..407	CDD:275368	5/15 (33%)
		C2H2 Zn finger	419..439	CDD:275368	11/19 (58%)
		C2H2 Zn finger	447..467	CDD:275368	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910