Protein Alignment topi and sens

DIOPT Version :10

• Sequence 1: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_524818.1
• Gene: sens / 45328
• FlyBaseID: FBgn0002573
• Length: 541
• Species: Drosophila melanogaster
• Alignment Length: 618
• Identity: 130/618 - (21%)
• Similarity: 219/618 - (35%)
• Gaps: 194/618 - (31%)

  Fly    56 FAVGPAGAL-----PM----PTDVVV---ERTLA-DPAFKQILQ----EADGKKGFDPQAEQMKI 103
            |.:..|.||     ||    |..||:   :|..| .|..:..||    ..:.|:.:..|.|.|.:
  Fly    73 FLLSSATALGTPLTPMTPKSPASVVLGQRDRDFALTPEKEHELQMNNNNENSKQDYQEQDEDMPL 137

  Fly   104 RDFLAGVTSSKMTTEQS---VFHGSRSNSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAV 165
            .  |:  |..::|::.|   .:|.|.:|||.|:                              :.
  Fly   138 N--LS--TKERITSDDSNRDQYHSSSNNSSRSS------------------------------SS 168

  Fly   166 PQQEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNEC 230
            .:.|:.|.:.:::..|.|||....:......|.|.|                 |:.|....|  .
  Fly   169 SEVEQLHPMTSLNVTPPPLSAVNLKSSSTPQQQRQR-----------------SQGNIIWSP--A 214

  Fly   231 TMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGL 295
            :||:|.        ...|::.|.: ..|..|:.|.:..     :|:     :..|:.:.|....|
  Fly   215 SMCERS--------ARREQYGLKM-EEQGDEEEHQVDP-----IVR-----KFKYERRTASISSL 260

  Fly   296 IHDSEHSTMRQSPMTQV--PSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGS 358
                      |||::.:  |::.|     :.|.|..:.....:|         .:..|.:.:.|:
  Fly   261 ----------QSPISSLSAPASNA-----VQDLEFEVAQQQLYA---------HRSAFMAGLTGN 301

  Fly   359 VLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNV 423
            .|             |||.......:|:..:    ..|.:..|:..   |.|   .|.|...:|:
  Fly   302 NL-------------ELLTQHLKLKSEQPQQ----QQQQHRIKDEQ---QQD---NRSAAALMNL 343

  Fly   424 TLSRYF--VCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHS 486
            ..:..|  :.|..:..       |:.:....|:..:..::..:...|       ...|.|....|
  Fly   344 VAAAEFGYMRNQHQQP-------QQQQQQQLHHQQQPQQHQHQQQHP-------DSTATDVARRS 394

  Fly   487 EEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFT 551
            ...  :..:.|.|.:.:|    |.:.|..||||:.:||.|..||..|...:|:.||
  Fly   395 SSS--SSYQGENEEKRSG----RNFQCKQCGKSFKRSSTLSTHLLIHSDTRPYPCQ--------- 444

  Fly   552 IRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNH 616
                                  .|||||...|...:|..||.||:.::|..|.|.|.::..|..|
  Fly   445 ----------------------YCGKRFHQKSDMKKHTYIHTGEKPHKCTVCLKAFSQSSNLITH 487

  Fly   617 QRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARH 649
            .|.|||.||:.|..|.::|:::.|..:|..:||
  Fly   488 MRKHTGYKPFGCHLCDQSFQRKVDLRRHRESRH 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370	4/19 (21%)
		C2H2 Zn finger	277..297	CDD:275370	3/19 (16%)
		C2H2 Zn finger	431..453	CDD:275368	2/21 (10%)
		COG5048	<450..647	CDD:227381	51/196 (26%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		C2H2 Zn finger	513..564	CDD:275368	14/50 (28%)
		C2H2 Zn finger	541..561	CDD:275368	2/19 (11%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:463886	11/24 (46%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
sens	NP_524818.1	zf-C2H2	413..435	CDD:395048	10/21 (48%)
		C2H2 Zn finger	415..435	CDD:275368	10/19 (53%)
		zf-C2H2	441..463	CDD:395048	9/52 (17%)
		C2H2 Zn finger	443..463	CDD:275368	9/50 (18%)
		zf-H2C2_2	455..480	CDD:463886	9/24 (38%)
		C2H2 Zn finger	471..491	CDD:275368	7/19 (37%)
		zf-H2C2_2	483..506	CDD:463886	10/22 (45%)
		C2H2 Zn finger	499..516	CDD:275368	4/16 (25%)