DRSC/TRiP Functional Genomics Resources

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Protein Alignment topi and Sry-beta

DIOPT Version :9

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:NP_001303451.1 Gene:Sry-beta / 43570 FlyBaseID:FBgn0003511 Length:356 Species:Drosophila melanogaster


Alignment Length:328 Identity:76/328 - (23%)
Similarity:116/328 - (35%) Gaps:103/328 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   302 STMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCE 366
            :|..:.|..| |....:..|.:  .|.::|.:..|:..:.:....::|.|:..   :.:.|..|.
  Fly   119 ATALKEPERQ-PGEEDECEEFM--KEEMLDEEFQFSEPDDSMPSSEEEFFTET---TEIPCHICG 177

  Fly   367 YIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVC 431
            .:|         |:..|.||..:...|.                              .|....|
  Fly   178 EMF---------SSQEVLERHIKADTCQ------------------------------KSEQATC 203

  Fly   432 NVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKR 496
            |||.||..:.::|..|          :|.:..|..|.|.:||..|....:.|.|. |.|.:||| 
  Fly   204 NVCGLKVKDDEVLDLH----------MNLHEGKTELECRYCDKKFSHKRNVLRHM-EVHWDKKK- 256

  Fly   497 EKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIR 561
                          |.||.||:.::.|..::.||..|..       |||.               
  Fly   257 --------------YQCDKCGERFSLSWLMYNHLMRHDA-------EENA--------------- 285

  Fly   562 KCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGER-RYECEECGKRFYRADALKNHQRIHTG-EK 624
                    .:|.||.::|.|...:..|...|:.:| ||.|.:|.|.|.....||.|:|:|.. ||
  Fly   286 --------LICEVCHQQFKTKRTYKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVHQPVEK 342

  Fly   625 PYS 627
            |.|
  Fly   343 PES 345

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275368
C2H2 Zn finger 277..297 CDD:275368
C2H2 Zn finger 431..453 CDD:275368 8/21 (38%)
COG5048 <450..647 CDD:227381 49/180 (27%)
C2H2 Zn finger 469..490 CDD:275368 7/20 (35%)
zf-C2H2 511..533 CDD:278523 8/21 (38%)
C2H2 Zn finger 513..564 CDD:275368 11/50 (22%)
C2H2 Zn finger 541..561 CDD:275368 3/19 (16%)
zf-H2C2_2 555..581 CDD:290200 4/25 (16%)
C2H2 Zn finger 572..592 CDD:275368 6/19 (32%)
zf-H2C2_2 585..609 CDD:290200 9/24 (38%)
zf-C2H2 598..620 CDD:278523 9/21 (43%)
C2H2 Zn finger 600..620 CDD:275368 8/19 (42%)
zf-H2C2_2 612..637 CDD:290200 9/17 (53%)
C2H2 Zn finger 628..646 CDD:275368 76/328 (23%)
Sry-betaNP_001303451.1 C2H2 Zn finger 203..223 CDD:275368 9/29 (31%)
C2H2 Zn finger 231..251 CDD:275368 7/20 (35%)
C2H2 Zn finger 259..308 CDD:275368 17/78 (22%)
C2H2 Zn finger 288..303 CDD:275370 5/14 (36%)
zf-C2H2 315..337 CDD:278523 9/21 (43%)
C2H2 Zn finger 317..337 CDD:275368 8/19 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446670
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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