Protein Alignment topi and su(Hw)

DIOPT Version :10

• Sequence 1: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_524349.1
• Gene: su(Hw) / 41740
• FlyBaseID: FBgn0003567
• Length: 941
• Species: Drosophila melanogaster
• Alignment Length: 849
• Identity: 173/849 - (20%)
• Similarity: 297/849 - (34%)
• Gaps: 200/849 - (23%)

  Fly    24 PDDLQPGATVLATNE----------STGGLERIVSHEELSRFFAVGPAGALPMPTDVVVERTLAD 78
            |.|.:|...:...|:          :|....|..|:::..|....|..      ..::.|..|..
  Fly    23 PKDKRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNKQEKRGSVAGSR------IKILNEEILGT 81

  Fly    79 PAFKQILQEADGKKGFDPQAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCL 143
            |.    .::....|...|.|..:||       .:.|.|...:|.....:....|...|.|....:
  Fly    82 PK----TEKRGATKSTAPAASTVKI-------LNEKKTPSATVTAVETTKIKTSPSKRKKMEHYV 135

  Fly   144 VQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEM 208
            :|    |.::.:.:|......|.:::     .|:....|...:....|:...|.   :..:..|.
  Fly   136 LQ----AVKSENTKADTTVTVVTEED-----DTIDFILADDEEVVPGRIENNNG---QEIVVTED 188

  Fly   209 KYDLA-TGIESSRKNAAKGPNE-----------CTMCDRKFVHASGLVRHMEKHALDLIPSQTSE 261
            ..||. .|.|....::.||.:.           |..|.:.|.....|.:|:|....|
  Fly   189 DEDLGEDGDEDGEDSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYD-------- 245

  Fly   262 QPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDG 326
                   :|.|                               :|::.|.:      :..::..|.
  Fly   246 -------SGYH-------------------------------LRKADMLK------NLEKIEKDA 266

  Fly   327 EMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVH-SASHVAERRFEC 390
            .::...|..|..|         |.:.:..||.: .|..|...|........| ..:|.....|.|
  Fly   267 VVMEKKDICFCCS---------ESYDTFHLGHI-NCPDCPKSFKTQTSYERHIFITHSEFSDFPC 321

  Fly   391 TACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHR----CTS 451
            :.|:..:.:....::|            ...:.:..:.:.|.:|...|..:..|:.|:    |:|
  Fly   322 SICNANLRSEALLALH------------EEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSS 374

  Fly   452 FHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDIC 516
                   ||..   .:.|..||..| :..|.|....::||..:..:|.          :|:|..|
  Fly   375 -------NETD---TMSCKVCDRVF-YRLDNLRSHLKQHLGTQVVKKP----------EYMCHTC 418

  Fly   517 GKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLT 581
            ...:...|.|..|:|.|.|.|||.|  :.||:||:....|..| |:.||||:||.|.||.:.|..
  Fly   419 KNCFYSLSTLNIHIRTHTGEKPFDC--DLCDKKFSALVALKKH-RRYHTGEKPYSCTVCNQAFAV 480

  Fly   582 GSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIR 646
            ..|..:|...|.|||.::|:||||.|.:|..|:.|.:.|.  :|:.|..|.:.|:.....::|::
  Fly   481 KEVLNRHMKRHTGERPHKCDECGKSFIQATQLRTHSKTHI--RPFPCEQCDEKFKTEKQLERHVK 543

  Fly   647 ARHSHLDANSRLMMQMQ--KFQLETAAAQKAQ----SHNPEQQDNDVAGGAS----TSDVPSGSG 701
            . ||.   ..|.:....  |....|.|..|..    .|:|:||.:.:.....    |........
  Fly   544 T-HSR---TKRPVFSCAECKRNFRTPALLKEHMDEGKHSPKQQRSSMRSAVKIMERTDCAICDKN 604

  Fly   702 FMSTEP------SVAEMQ----YSITPE---------QQEEMVCVPIDEVNNSFFMSH------- 740
            |.|::.      :|.|..    :.:.|.         :.||:|.|.::....|...|.
  Fly   605 FDSSDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDIESEEVVPVALNTSAGSLISSQTDGNGVV 669

  Fly   741 YMQAVPMEEDGSGQHIIVFEQPGQNMDMMSIYDQQQVGEPMHESGVPKRPAEENARV-VVVKNNP 804
            ..:.:..|.||:.|.|.:..:....:.:....:.:|:.:   |:||.....:|.|:| .|||...
  Fly   670 VREFLVDEGDGAAQTITLENETYTILPLDGAIEGEQLTD---EAGVKPEAKKEEAQVSPVVKKEQ 731

  Fly   805 TKPI 808
            .|.:
  Fly   732 RKSL 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275370	0/19 (0%)
		C2H2 Zn finger	431..453	CDD:275368	7/25 (28%)
		COG5048	<450..647	CDD:227381	63/196 (32%)
		C2H2 Zn finger	469..490	CDD:275368	6/20 (30%)
		C2H2 Zn finger	513..564	CDD:275368	19/50 (38%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:463886	7/24 (29%)
		C2H2 Zn finger	628..646	CDD:275368	4/17 (24%)
su(Hw)	NP_524349.1	C2H2 Zn finger	292..313	CDD:275368	4/20 (20%)
		COG5048	<312..517	CDD:227381	68/240 (28%)
		C2H2 Zn finger	321..341	CDD:275368	3/31 (10%)
		C2H2 Zn finger	350..368	CDD:275368	5/17 (29%)
		C2H2 Zn finger	382..402	CDD:275368	6/20 (30%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		C2H2 Zn finger	443..463	CDD:275368	8/22 (36%)
		COG5048	<467..620	CDD:227381	42/158 (27%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		C2H2 Zn finger	499..519	CDD:275368	9/19 (47%)
		C2H2 Zn finger	525..545	CDD:275368	4/20 (20%)
		C2H2 Zn finger	555..572	CDD:275368	4/16 (25%)
		C2H2 Zn finger	598..615	CDD:275371	2/16 (13%)