DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment topi and MAZ

DIOPT Version :9

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:NP_001036004.1 Gene:MAZ / 4150 HGNCID:6914 Length:493 Species:Homo sapiens


Alignment Length:693 Identity:129/693 - (18%)
Similarity:200/693 - (28%) Gaps:291/693 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 VSHEELSRFF-----AVGPAGALPMPTDVVVERTLADPAFKQILQEADGKKGFDPQAEQMKIRDF 106
            |..|..||||     |..|..|.|.|           |...|.           |.||.::: |.
Human    44 VGAELQSRFFASQGCAQSPFQAAPAP-----------PPTPQA-----------PAAEPLQV-DL 85

  Fly   107 LAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKP 171
            |..:.:::   |.:....:.:.::|:.......|......|..|.:.......|           
Human    86 LPVLAAAQ---ESAAAAAAAAAAAAAVAAAPPAPAAASTVDTAALKQPPAPPPP----------- 136

  Fly   172 HLVPTVSAPPAPLSKPASERVIR----------ENQVRLRRYIKDEMKYDLATGIESSRKNAAKG 226
              .|.||||.|..:.|||...|.          .:.|.:.         .:|:.:|  :|..:||
Human   137 --PPPVSAPAAEAAPPASAATIAAAAATAVVAPTSTVAVA---------PVASALE--KKTKSKG 188

  Fly   227 PNECTMCDRKFVHASGLVRHMEKHA---LDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQ 288
            |..|.:|.::|.:...|.||...|.   ...:||...:.|..:|.:.|.|             ||
Human   189 PYICALCAKEFKNGYNLRRHEAIHTGAKAGRVPSGAMKMPTMVPLSLLSV-------------PQ 240

  Fly   289 VAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSS 353
            ::...|                             ..||.......|                 :
Human   241 LSGAGG-----------------------------GGGEAGAGGGAA-----------------A 259

  Fly   354 LILGSVL-------------QCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASI 405
            :..|.|:             .||.|...|.|:..|..|..||..|:.::|.              
Human   260 VAAGGVVTTTASGKRIRKNHACEMCGKAFRDVYHLNRHKLSHSDEKPYQCP-------------- 310

  Fly   406 HFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCD 470
                                       ||:.:|...|.:      |:|.                
Human   311 ---------------------------VCQQRFKRKDRM------SYHV---------------- 326

  Fly   471 FCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQG 535
                   .:||...|                       :.|.|..||||:::..|          
Human   327 -------RSHDGAVH-----------------------KPYNCSHCGKSFSRPDH---------- 351

  Fly   536 VKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYEC 600
                                ||.|:|:.|:.|||:.|..|...|.|......|.:.|  |.:..|
Human   352 --------------------LNSHVRQVHSTERPFKCEKCEAAFATKDRLRAHTVRH--EEKVPC 394

  Fly   601 EECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTF------RQRGDRDKHIRARHSHLDANSRLM 659
            ..|||....| .:.:|.::|:....:.|..|.|.|      |....:|..::|..:     .|::
Human   395 HVCGKMLSSA-YISDHMKVHSQGPHHVCELCNKGFTTAAYLRIHAVKDHGLQAPRA-----DRIL 453

  Fly   660 MQMQKFQLETAA--AQKAQSHNPEQQDNDVAGGAS---TSDVP 697
            .::.....:|.|  |...|:|         .|||:   ..|.|
Human   454 CKLCSVHCKTPAQLAGHMQTH---------LGGAAPPVPGDAP 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275368 6/19 (32%)
C2H2 Zn finger 277..297 CDD:275368 3/19 (16%)
C2H2 Zn finger 431..453 CDD:275368 5/21 (24%)
COG5048 <450..647 CDD:227381 40/202 (20%)
C2H2 Zn finger 469..490 CDD:275368 3/20 (15%)
zf-C2H2 511..533 CDD:278523 7/21 (33%)
C2H2 Zn finger 513..564 CDD:275368 10/50 (20%)
C2H2 Zn finger 541..561 CDD:275368 3/19 (16%)
zf-H2C2_2 555..581 CDD:290200 11/25 (44%)
C2H2 Zn finger 572..592 CDD:275368 5/19 (26%)
zf-H2C2_2 585..609 CDD:290200 7/23 (30%)
zf-C2H2 598..620 CDD:278523 6/21 (29%)
C2H2 Zn finger 600..620 CDD:275368 6/19 (32%)
zf-H2C2_2 612..637 CDD:290200 6/30 (20%)
C2H2 Zn finger 628..646 CDD:275368 6/23 (26%)
MAZNP_001036004.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..78 8/40 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 121..146 8/37 (22%)
C2H2 Zn finger 192..212 CDD:275368 6/19 (32%)
C2H2 Zn finger 281..301 CDD:275368 7/19 (37%)
SFP1 <303..360 CDD:227516 22/179 (12%)
C2H2 Zn finger 309..329 CDD:275368 7/89 (8%)
C2H2 Zn finger 339..357 CDD:275368 9/47 (19%)
C2H2 Zn finger 368..388 CDD:275368 5/19 (26%)
C2H2 Zn finger 394..413 CDD:275368 6/19 (32%)
C2H2 Zn finger 421..437 CDD:275368 5/15 (33%)
C2H2 Zn finger 454..474 CDD:275368 4/19 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24390
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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