DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and CG8319

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_649920.2	Gene:	CG8319 / 41165	FlyBaseID:	FBgn0037722	Length:	383	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	114/483 - (23%)
Similarity:	166/483 - (34%)	Gaps:	155/483 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 CTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHG 294
            |.:|       .|...:|    |.:...|..|.   :..|.|..:||  :|..:..||..|....
  Fly     5 CRIC-------GGASENM----LGIFDDQVEEY---VDGAKLAEMVK--TCADVQLDPDDAMPQK 53

  Fly   295 L----IHDSE--HSTMRQSPMTQVPSNRADFNELLLDGEMLID--NDPAFATSNQNTNPPK---- 347
            :    :||:.  :...|     :...|...|...:|:|:::.|  |:..|....   ||.|
  Fly    54 MCISCVHDARTAYGFKR-----RCEENYKKFYLAILNGQVIKDEPNEEDFLFIE---NPDKGNLE 110

  Fly   348 ------KEM-----------FSSL-----------ILGSVLQCEFCEYIFADIAELL----VHSA 380
                  ||:           .||:           |.....:||.|...|.....||    |||.
  Fly   111 AKKKLNKEIKKTHQTASRTTKSSITTSRAGRQLRSIKNQTFKCELCIKQFKRQINLLDHMKVHSN 175

  Fly   381 SHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQ 445
            |||      |..|        |....|:.| :...:..|:.|.|:.    |..|...|::|..|.
  Fly   176 SHV------CQNC--------EERFLFKAD-LDNHQCYRNSNSTVE----CPECLKVFSSTQSLD 221

  Fly   446 EHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQ 510
            .|:|                                           |..:|:.          .
  Fly   222 SHKC-------------------------------------------KDMQERS----------P 233

  Fly   511 YLCDICGKSYTQSSHLWQHLRFH----QGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYL 571
            :.|..|.:::|:..:|..||..|    ||..|..|  ..|...|..:..|..||. .|.||||:.
  Fly   234 FQCPHCQQAFTREQNLKAHLLIHAESKQGNGPHKC--SYCQTGFFNKSALKVHIH-AHMGERPHA 295

  Fly   572 CLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFR 636
            |..|...|.:......|..||.||:.|:|..|.|.|...:.|..|:|.|:.|:||.|..|.:.|
  Fly   296 CPFCVSNFRSKQALKVHIRIHTGEKPYQCPHCPKTFSDNNNLAKHRRRHSDERPYKCSICLQDF- 359

  Fly   637 QRGDRDKHIRARH---SHLDANSRLMMQ 661
                |:||...||   .|.|.:.:|.::
  Fly   360 ----REKHHLKRHFLGKHRDGDQKLKLK 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	4/19 (21%)
		C2H2 Zn finger	277..297	CDD:275368	4/23 (17%)
		C2H2 Zn finger	431..453	CDD:275368	7/21 (33%)
		COG5048	<450..647	CDD:227381	49/200 (25%)
		C2H2 Zn finger	469..490	CDD:275368	0/20 (0%)
		zf-C2H2	511..533	CDD:278523	6/21 (29%)
		C2H2 Zn finger	513..564	CDD:275368	16/54 (30%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		zf-H2C2_2	555..581	CDD:290200	11/25 (44%)
		C2H2 Zn finger	572..592	CDD:275368	4/19 (21%)
		zf-H2C2_2	585..609	CDD:290200	10/23 (43%)
		zf-C2H2	598..620	CDD:278523	8/21 (38%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:290200	10/24 (42%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
CG8319	NP_649920.2	zf-AD	4..79	CDD:285071	19/94 (20%)
		COG5048	<153..368	CDD:227381	76/294 (26%)
		C2H2 Zn finger	153..173	CDD:275368	6/19 (32%)
		C2H2 Zn finger	179..196	CDD:275368	5/25 (20%)
		C2H2 Zn finger	207..227	CDD:275370	7/62 (11%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		C2H2 Zn finger	268..288	CDD:275368	6/22 (27%)
		C2H2 Zn finger	296..316	CDD:275368	4/19 (21%)
		zf-H2C2_2	308..332	CDD:290200	9/23 (39%)
		zf-C2H2	322..344	CDD:278523	8/21 (38%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		C2H2 Zn finger	352..368	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446684
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030