DRSC/TRiP Functional Genomics Resources

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Protein Alignment topi and CG14655

DIOPT Version :9

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:NP_649494.1 Gene:CG14655 / 40594 FlyBaseID:FBgn0037275 Length:525 Species:Drosophila melanogaster


Alignment Length:540 Identity:128/540 - (23%)
Similarity:187/540 - (34%) Gaps:164/540 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   360 LQCEF--CEYIFADIAELLVHSASH---VAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIR 419
            |.|.|  |:.:|..:.:|.:|..||   :|:...|..|     |....:|..|.......|.|.|
  Fly    34 LACPFANCKELFLGLDKLTIHLFSHTSLMAQEGNESPA-----NGQPASSRGFLAAAPPKRRAKR 93

  Fly   420 SLNVTLSRYFV-------------CNVCELKFANTDLLQEHRCTSFHYFPRL-NENGK---KLLL 467
                |.|:..|             |::||..|.||:|...|        .|| :||.:   |...
  Fly    94 ----TRSKPVVPTPPPVRTTPPAHCDICEFSFRNTELRDMH--------VRLVHENAEGEPKQKE 146

  Fly   468 P-----------CDFCDVNFEFAHDFLAHSEEKH------------------------------- 490
            |           |..|...|........|.:..|                               
  Fly   147 PQQKEPDQEPYKCHLCSKTFRMKGSLRIHLKVVHMMGVPCSNPNPNPNPSPTPASTTSAVTATPK 211

  Fly   491 ----------------------------------LNKKKREKETRNTGAGRIRQYLCDICGKSYT 521
                                              |:..::...:..:|....:.:.||:|.||:|
  Fly   212 LSICDRIRHTEPGALGNGNNSTCTASQPYALSGALSMLQQSPSSPESGTATPKLWECDVCSKSFT 276

  Fly   522 QSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFY 586
            ....|.:|.|.|.|..|:.|  |.|.|.||.:...:.|: ..|:..:|::|.|||:.|...|..:
  Fly   277 TKYFLKKHKRLHTGEMPYTC--EICARTFTFQQSYHKHL-LYHSEVKPHVCGVCGRAFKELSTLH 338

  Fly   587 QHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSH 651
            .|:.||.||:.::||.|||.|.:..:...|.|||||..||.|..|.||||.:..:..|       
  Fly   339 NHQRIHSGEKPFKCEVCGKCFRQRVSFLVHTRIHTGVMPYKCELCQKTFRYKVSQRTH------- 396

  Fly   652 LDANSRLMMQMQKFQLETAAAQKAQSHNPEQQDNDVAGGASTSDVPSGSGFMSTEPSVAEM---- 712
                          :..|..||     .|||.......|..:...||        |:.||:    
  Fly   397 --------------RCPTEEAQ-----TPEQLIKAFLEGNDSHTQPS--------PASAEIAAIN 434

  Fly   713 QYSITPEQQEEMVCVPIDEVNNSFFMSHYMQAVPMEEDG---SGQHIIVFE-----QPGQNMDMM 769
            ..||...:||.::...||::.........:..|...|:|   |.|.:.|..     .|.|.:..:
  Fly   435 SSSIVDPEQEALLSQSIDDIVVEQCQKLGICGVEPREEGQLISLQPVAVVHFSGNGSPLQQLQNL 499

  Fly   770 SIYDQQQVGEPMHESGVPKR 789
            .||..||...|..:..|.:|
  Fly   500 RIYSPQQTELPSSDGEVFQR 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275368
C2H2 Zn finger 277..297 CDD:275368
C2H2 Zn finger 431..453 CDD:275368 8/21 (38%)
COG5048 <450..647 CDD:227381 66/276 (24%)
C2H2 Zn finger 469..490 CDD:275368 4/20 (20%)
zf-C2H2 511..533 CDD:278523 9/21 (43%)
C2H2 Zn finger 513..564 CDD:275368 19/50 (38%)
C2H2 Zn finger 541..561 CDD:275368 7/19 (37%)
zf-H2C2_2 555..581 CDD:290200 8/25 (32%)
C2H2 Zn finger 572..592 CDD:275368 7/19 (37%)
zf-H2C2_2 585..609 CDD:290200 11/23 (48%)
zf-C2H2 598..620 CDD:278523 8/21 (38%)
C2H2 Zn finger 600..620 CDD:275368 8/19 (42%)
zf-H2C2_2 612..637 CDD:290200 13/24 (54%)
C2H2 Zn finger 628..646 CDD:275368 7/17 (41%)
CG14655NP_649494.1 C2H2 Zn finger 268..288 CDD:275368 9/19 (47%)
zf-H2C2_2 281..304 CDD:290200 10/24 (42%)
C2H2 Zn finger 324..344 CDD:275368 7/19 (37%)
zf-H2C2_2 339..361 CDD:290200 11/21 (52%)
C2H2 Zn finger 352..372 CDD:275368 8/19 (42%)
zf-H2C2_2 364..389 CDD:290200 13/24 (54%)
C2H2 Zn finger 380..396 CDD:275368 6/15 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24390
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
11.100

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