Protein Alignment topi and CG11247

DIOPT Version :10

• Sequence 1: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_649351.2
• Gene: CG11247 / 40414
• FlyBaseID: FBgn0037120
• Length: 522
• Species: Drosophila melanogaster
• Alignment Length: 495
• Identity: 122/495 - (24%)
• Similarity: 184/495 - (37%)
• Gaps: 143/495 - (28%)

  Fly   176 TVSAPPAPL-SKPASERVIRENQ---VRLRRYIKDEMKYDLATGIESS----------RKNAAKG 226
            ::|:|||.. |.|.....|:..:   ..||....||.:.|  .|.:.|          :|:|.||
  Fly    23 SLSSPPAARESSPGPTLAIKRRKSSLASLRDACVDEEEDD--GGEQDSKDDDYVQPQLKKSARKG 85

  Fly   227 P------NECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFY 285
            .      :.|:.|.::|...:.|.|||..|        :.|:||           ||..||: .|
  Fly    86 EPVKRKHHVCSQCSKEFGGKTDLQRHMLIH--------SDERPH-----------KCKDCGK-SY 130

  Fly   286 DPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEM 350
            ...|..::.:....||  .:|...:|.|.:.|....|.|...:         .|.:...|
  Fly   131 RQAVNLKNHITTAHEH--RKQFVCSQCPKSFALKERLRLHMRL---------HSGEKPYP----- 179

  Fly   351 FSSLILGSVLQCEFCEYIFADIAELLVHSASH--VAERRFECTACDIQMNTAKEASIHFQTDCIF 413
                       |:.|:..||...:|..|..||  .:.::|.||.|....:|.....:|.:.....
  Fly   180 -----------CDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQG 233

  Fly   414 MREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEF 478
            |...             |::||.:|||...|:.|                          :|
  Fly   234 MEHR-------------CSICENQFANELALRAH--------------------------IN--- 256

  Fly   479 AHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQE 543
                    :|.|                ::.|:.|:||.|.......|..|::.|..||..||
  Fly   257 --------QEHH----------------KLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVC-- 295

  Fly   544 ENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKR-- 606
            |.|:..||.:...|.|:| .|||||||.|.:|.:.|...||...|...|.||:.:.|:.|...
  Fly   296 EVCNTYFTQKSQYNVHMR-MHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVA 359

  Fly   607 FYRADALKNH-QRIHTGEKPYSCLFCTKTFRQRGDRDKHI 645
            |.:...|||| ::||..:|||.|..|...|:.:.:...|:
  Fly   360 FSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHV 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275370	5/19 (26%)
		C2H2 Zn finger	431..453	CDD:275368	8/21 (38%)
		COG5048	<450..647	CDD:227381	54/199 (27%)
		C2H2 Zn finger	469..490	CDD:275368	2/20 (10%)
		C2H2 Zn finger	513..564	CDD:275368	18/50 (36%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		C2H2 Zn finger	600..620	CDD:275368	7/22 (32%)
		zf-H2C2_2	612..637	CDD:463886	12/25 (48%)
		C2H2 Zn finger	628..646	CDD:275368	4/18 (22%)
CG11247	NP_649351.2	COG5048	<88..247	CDD:227381	46/218 (21%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		C2H2 Zn finger	123..144	CDD:275368	5/21 (24%)
		C2H2 Zn finger	152..172	CDD:275368	5/28 (18%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	62/245 (25%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	10/58 (17%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	8/22 (36%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	3/16 (19%)