DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment topi and Neu2

DIOPT Version :9

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:NP_649316.1 Gene:Neu2 / 40375 FlyBaseID:FBgn0037085 Length:382 Species:Drosophila melanogaster


Alignment Length:270 Identity:70/270 - (25%)
Similarity:99/270 - (36%) Gaps:68/270 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   469 CDFCDVNFEFAHDFLAHSEEKH----LNKKKREKETRNTGAGRIRQ------------------- 510
            |..|..:.:.|.|.:...|..|    ..|..||:|:.|.|:|...:                   
  Fly    38 CKSCLEDAQNAFDIIETYERSHQFYRFLKDVREEESENDGSGCSEEVEAAERDLQDGADDVDSGN 102

  Fly   511 ----------------YLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDH 559
                            :.|..|.||:...|:|..|:|.|.|.:||.|  ..|.:.|.....|.:|
  Fly   103 EPDINECDIKAKEKPGFSCSHCPKSFQVKSNLKVHMRSHTGERPFTC--SLCPKSFGYSSGLQNH 165

  Fly   560 IRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEK 624
            :| .||||||:.|..|.:.|..|.....|..:|.......|..|.|.|..:..||.|...||.|.
  Fly   166 MR-THTGERPFQCSHCPRSFTAGHHLKAHIQMHERRGSLRCPYCQKCFLTSLILKQHLATHTDET 229

  Fly   625 PYSCLFCTKTFRQRGDRDKHIR----------------ARHS----HLDANSRLMMQMQKFQLET 669
            .:.|..|:|:|:...:...|:|                |.|:    ||..|:|..      |...
  Fly   230 QFKCSQCSKSFQVEHELWMHMRVHQERLFTCGHCSKDFALHAYLKRHLSRNARCS------QSSK 288

  Fly   670 AAAQKAQSHN 679
            |:|.|...|:
  Fly   289 ASAHKTLGHS 298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275368
C2H2 Zn finger 277..297 CDD:275368
C2H2 Zn finger 431..453 CDD:275368
COG5048 <450..647 CDD:227381 59/232 (25%)
C2H2 Zn finger 469..490 CDD:275368 5/20 (25%)
zf-C2H2 511..533 CDD:278523 8/21 (38%)
C2H2 Zn finger 513..564 CDD:275368 18/50 (36%)
C2H2 Zn finger 541..561 CDD:275368 5/19 (26%)
zf-H2C2_2 555..581 CDD:290200 12/25 (48%)
C2H2 Zn finger 572..592 CDD:275368 5/19 (26%)
zf-H2C2_2 585..609 CDD:290200 6/23 (26%)
zf-C2H2 598..620 CDD:278523 7/21 (33%)
C2H2 Zn finger 600..620 CDD:275368 7/19 (37%)
zf-H2C2_2 612..637 CDD:290200 10/24 (42%)
C2H2 Zn finger 628..646 CDD:275368 5/17 (29%)
Neu2NP_649316.1 zf-AD 1..63 CDD:285071 6/24 (25%)
COG5048 <119..241 CDD:227381 43/124 (35%)
C2H2 Zn finger 121..141 CDD:275368 8/19 (42%)
zf-H2C2_2 133..158 CDD:290200 10/26 (38%)
C2H2 Zn finger 149..169 CDD:275368 6/22 (27%)
zf-H2C2_2 162..185 CDD:290200 11/23 (48%)
C2H2 Zn finger 177..197 CDD:275368 5/19 (26%)
C2H2 Zn finger 205..225 CDD:275368 7/19 (37%)
zf-C2H2_8 206..286 CDD:292531 21/85 (25%)
C2H2 Zn finger 233..253 CDD:275368 6/19 (32%)
C2H2 Zn finger 260..297 CDD:275368 10/42 (24%)
C2H2 Zn finger 303..323 CDD:275368
C2H2 Zn finger 353..373 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446590
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.930

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